2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature

Valeria Azzarito; Panchami Prabhakaran; Alice I. Bartlett; Natasha S. Murphy; Michaele J. Hardie; Colin A. Kilner; Thomas A. Edwards; Stuart L. Warriner; Andrew J. Wilson

doi:10.1039/c2ob26262b

2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature

Valeria Azzarito, Panchami Prabhakaran, Alice I. Bartlett, Natasha S. Murphy, Michaele J. Hardie, Colin A. Kilner, Thomas A. Edwards, Stuart L. Warriner, Andrew J. Wilson^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.

Original language	English
Pages (from-to)	6469-6472
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	32
DOIs	https://doi.org/10.1039/c2ob26262b
Publication status	Published - 28 Aug 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature",

abstract = "The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.",

author = "Valeria Azzarito and Panchami Prabhakaran and Bartlett, {Alice I.} and Murphy, {Natasha S.} and Hardie, {Michaele J.} and Kilner, {Colin A.} and Edwards, {Thomas A.} and Warriner, {Stuart L.} and Wilson, {Andrew J.}",

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T2 - The role of scaffold curvature

AU - Azzarito, Valeria

AU - Prabhakaran, Panchami

AU - Bartlett, Alice I.

AU - Murphy, Natasha S.

AU - Hardie, Michaele J.

AU - Kilner, Colin A.

AU - Edwards, Thomas A.

AU - Warriner, Stuart L.

AU - Wilson, Andrew J.

PY - 2012/8/28

Y1 - 2012/8/28

N2 - The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.

AB - The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.

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AN - SCOPUS:84864450122

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EP - 6472

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

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ER -

2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature

Abstract

ASJC Scopus subject areas

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