Projects per year
Abstract
IMPORTANCE OF THE FIELD: The prevalence of obesity and type 2 diabetes is rising and reaching pandemic proportions. For this reason, identification of novel therapeutic targets is urgently needed. AREAS COVERED IN THIS REVIEW: The endoluminal enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes glucocorticoid activation in key metabolic tissues including skeletal muscle, liver and adipose tissue, and is strongly implicated in the pathogenesis of obesity, type 2 diabetes and the metabolic syndrome. Selective 11beta-HSD1 inhibitors limit local glucocorticoid availability and improve insulin sensitivity, glucose tolerance, lipid profiles and atherosclerosis. To date, there is a paucity of clinical studies using selective 11beta-HSD1 inhibitors; however, early indications show that these compounds have great therapeutic potential. WHAT THE READER WILL GAIN: We present a comprehensive overview of the background to the development of selective 11beta-HSD1 inhibitors, the preclinical data supporting 11beta-HSD1 as a therapeutic target, and the current status of clinical trials of these agents. TAKE HOME MESSAGE: Selective 11beta-HSD1 inhibitors have the potential to improve insulin sensitivity and may ultimately add to the treatment options available for patients with type 2 diabetes. However, further clinical studies are urgently required.
Original language | English |
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Pages (from-to) | 1067-76 |
Number of pages | 10 |
Journal | Expert opinion on investigational drugs |
Volume | 19 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Sept 2010 |
Keywords
- glucocorticoids
- 11beta-hydroxysteroid dehydrogenase type 1
- metabolic syndrome
- obesity
- 11 beta-HSD1
- insulin resistance
- type 2 diabetes
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- 1 Finished
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Glucocorticoid Metabolism and the Control of Metabolic Phenotype
Tomlinson, J. (Principal Investigator)
1/10/09 → 30/09/14
Project: Research Councils