Abstract
1,3,5-Substituted pyrrolidin-2-ones were synthesised via an iodine mediated cyclisation of 3-methyl substituted homoallylamines in good to excellent yield, as mixtures of diastereoisomers. These were separable and their identity confirmed by techniques including single crystal X-ray diffraction. When 3-phenyl substituted homoallylamines were cyclised intriguing fused tricyclic motifs were obtained as C2-symmetric racemates, whose structures were also confirmed by techniques including single crystal X-ray diffraction analysis.
Original language | English |
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Pages (from-to) | 1445-1449 |
Number of pages | 5 |
Journal | Organic Chemistry Frontiers |
Volume | 2 |
Issue number | 11 |
Early online date | 27 Aug 2015 |
DOIs | |
Publication status | Published - 1 Nov 2015 |