γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

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Abstract

Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.

Original languageEnglish
Pages (from-to)551-553
Number of pages3
JournalTrends in Biochemical Sciences
Volume45
Issue number7
Early online date13 Apr 2020
DOIs
Publication statusPublished - 1 Jul 2020

Keywords

  • T cell receptor (TCR)
  • complementarity determining region (CDR)
  • gamma delta
  • major histocompatibility complex (MHC)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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