βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function

Luis Arnes, Ildem Akerman, Dina A Balderes, Jorge Ferrer, Lori Sussel

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)
110 Downloads (Pure)

Abstract

Pancreatic β cells are responsible for maintaining glucose homeostasis; their absence or malfunction results in diabetes mellitus. Although there is evidence that long noncoding RNAs (lncRNAs) play important roles in development and disease, none have been investigated in vivo in the context of pancreas development. In this study, we demonstrate that βlinc1 (β-cell long intergenic noncoding RNA 1), a conserved lncRNA, is necessary for the specification and function of insulin-producing β cells through the coordinated regulation of a number of islet-specific transcription factors located in the genomic vicinity of βlinc1. Furthermore, deletion of βlinc1 results in defective islet development and disruption of glucose homeostasis in adult mice.

Original languageEnglish
Pages (from-to)502-507
Number of pages6
JournalGenes & Development
Volume30
Issue number5
DOIs
Publication statusPublished - 1 Mar 2016

Keywords

  • Animals
  • Cell Line
  • Endocrine System
  • Gene Expression Regulation, Developmental
  • Gene Knockout Techniques
  • Glucose Intolerance
  • Humans
  • Insulin-Secreting Cells
  • Mice
  • Mice, Inbred C57BL
  • RNA, Long Noncoding
  • Transcription Factors
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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