Using predisposition genes to understand and prevent colorectal cancer

Tomlinson, Ian (Principal Investigator)

Cancer and Genomic Sciences

Short title	Using predisposition genes to understand and prevent colorectal cancer
Status	Finished
Effective start/end date	1/04/19 → 31/01/24

Funding

Cancer Research UK

2 Article

Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis
Palles, C., Freeman-Mills, L., Arbe-Barnes, E., Feeley, N., Chegwidden, L., Curley, H., Galavotti, S., Woolley, C., Cheadle, J., Mouradov, D., Sieber, O., Salatino, S., Thorn, S., Goel, A., Fernandez-Tajes, J., Omwenga, S., Biswas, S., Maughan, T., Leedham, S. J. & S:CORT Consortium & 8 others, UK Colorectal Cancer Genomics Consortium, Colorectal Tumour Gene Identification (CORGI) Consortium, WGS500 Consortium, Koelzer, V. H., Wang, L. M., Arnold, R., East, J. E. & Tomlinson, I., 24 Dec 2025, (E-pub ahead of print) In: Gut. 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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Replication-associated mechanisms contribute to an increased CpG > TpG mutation burden in mismatch repair-deficient cancers
Ward, J. C., Soriano, I., Thorn, S., Fernández-Tajes, J., Sherwood, K., Gül, G., Scheffers, J., Frangou, A., Kinnersley, B., Kafetzopoulos, I., Sproul, D., Galavotti, S., Palles, C., Gruber, A. J., Church, D. N. & Tomlinson, I., 25 Aug 2025, In: Genome medicine. 17, 1, 20 p., 95.
Research output: Contribution to journal › Article › peer-review

Open Access
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2 Downloads (Pure)