Use of induced pluripotent stem cell derived cardiomyocytes to test the consequences of genetic variants in atrial and ventricular arrhythmias

Gehmlich, Katja (Principal Investigator)

Cardiovascular Sciences

Short title	Use of induced pluripotent stem cell derived cardiomyocytes to test the consequences of genetic variants in atrial and ventricular arrhythmias
Status	Finished
Effective start/end date	1/06/20 → 5/01/24

Funding

NATIONAL CENTRE FOR THE REPLACEMENT, REFINEMENT & REDUCTION OF ANIMALS IN RESEARCH

An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten
Leinhos, L., Robinson, P., Poloni, G., Broadway-Stringer, S., Beglov, J., Lokman, A. B., Douglas, G., Nuthay, S., Fonseka, O., Schmid, M., Singer, E., Hooper, C., Thomson, K., Bagnall, R. D., Ingles, J., Semsarian, C., Ormondroyd, E., Toepfer, C. N., Davies, B. & Redwood, C. R. & 2 others, Watkins, H. & Gehmlich, K., 24 Mar 2025, In: Scientific Reports. 15, 14 p., 10090.
Research output: Contribution to journal › Article › peer-review

Open Access
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Substrate Stiffness‐Dependent Metabolic Reprogramming of iPSC‐Derived cardiomyocytes on Physiological PDMS Polymers
Patel, L., Marzullo, B. P., Barlow, J., Rana, H., Azad, A. J., Thomas, P., Tennant, D. A. & Gehmlich, K., Dec 2025, In: Metabolic Engineering Communications. 21, 15 p., e00266.
Research output: Contribution to journal › Article › peer-review

Open Access
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Arrhythmogenesis in Fabry Disease
Roy, A., Cumberland, M., O'Shea, C., Holmes, A., Kalla, M., Gehmlich, K., Geberhiwot, T. & Steeds, R., 12 Apr 2024, (E-pub ahead of print) In: Current cardiology reports.
Research output: Contribution to journal › Article › peer-review

Open Access
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61 Downloads (Pure)