Understanding the molecular basis and consequences of chemoradiosensitivity in rectal cancer in order to improve tharapy (MOL-RSRC)

Research output

Research output per year 2020 2020 2021 2023

• 15 Article
• 2 Review article

Research output per year

Research output per year

Search results

• 2023

  MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids

  Pickles, O. J., Wanigasooriya, K., Ptasinska, A., Patel, A. J., Robbins, H. L., Bryer, C., Whalley, C. M., Tee, L., Lal, N., Pinna, M., Elzefzafy, N., Taniere, P., Beggs, A. D. & Middleton, G. M., 9 Aug 2023, In: Cancer Research Communications. 3, 8, p. 1501-1513 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Organoids 100%
  • Colorectal Neoplasms 60%
  • Epigenomics 35%
  • Neoplasms 24%
  • Methylation 15%
  42 Downloads (Pure)
• 2022

  Machine learning for determining lateral flow device results for testing of SARS-CoV-2 infection in asymptomatic populations

  The LFD AI Consortium, 18 Oct 2022, In: Cell Reports Medicine. 3, 10, 11 p., 100784.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Coronavirus Infections 100%
  • Severe Acute Respiratory Syndrome 90%
  • Machine Learning 78%
  • Flow 44%
  • Equipment and Supplies 41%
  32 Downloads (Pure)

• Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer

  Wanigasooriya, K., Barros-silva, J. D., Tee, L., El-asrag, M. E., Stodolna, A., Pickles, O. J., Stockton, J., Bryer, C., Hoare, R., Whalley, C. M., Tyler, R., Sillo, T., Yau, C., Ismail, T. & Beggs, A. D., 4 Jul 2022, In: Frontiers in Oncology. 12, 920444.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Organoids 100%
  • Rectal Neoplasms 78%
  • Phosphatidylinositol 3-Kinases 75%
  • Up-Regulation 33%
  • Chemoradiotherapy 32%
  122 Downloads (Pure)
• 2021

  Diagnostic accuracy of loop-mediated isothermal amplification coupled to nanopore sequencing (LamPORE) for the detection of SARS-CoV-2 infection at scale in symptomatic and asymptomatic populations

  Ptasinska, A., Whalley, C., Bosworth, A., Poxon, C., Bryer, C., Machin, N., Grippon, S., Wise, E. L., Armson, B., Howson, E. L. A., Goring, A., Snell, G., Forster, J., Mattocks, C., Frampton, S., Anderson, R., Cleary, D., Parker, J., Boukas, K., Graham, N., & 21 othersCellura, D., Garratt, E., Skilton, R., Sheldon, H., Collins, A., Ahmad, N., Friar, S., Burns, D., Williams, T., Godfrey, K. M., Deans, Z., Douglas, A., Hill, S., Kidd, M., Porter, D., Kidd, S. P., Cortes, N. J., Fowler, V., Williams, T., Richter, A. & Beggs, A. D., 23 Apr 2021, (E-pub ahead of print) In: Clinical Microbiology and Infection. 27, 9, p. 1348.e1-1348.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nanopore Sequencing 100%
  • Coronavirus Infections 84%
  • Severe Acute Respiratory Syndrome 76%
  • Coronavirus 74%
  • Saliva 28%
  165 Downloads (Pure)

• Genetic modifiers in rare disorders: the case of fragile X syndrome

  Crawford, H., Scerif, G., Wilde, L., Beggs, A., Stockton, J., Sandhu, P., Shelley, L., Oliver, C. & McCleery, J., Jan 2021, In: European Journal of Human Genetics. 29, 1, p. 173–183 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fragile X Syndrome 100%
  • Genotype 55%
  • Pleasure 54%
  • Single Nucleotide Polymorphism 51%
  • Stereotyped Behavior 42%
  2 Citations (Scopus)

  152 Downloads (Pure)

• How to set up and run a surgical research laboratory

  Beggs, A. D., 29 Oct 2021, In: Journal of Surgical Protocols and Research Methodologies. 2021, 1, snab007.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • academic career 100%
  • surgery 92%
  30 Downloads (Pure)

• Multi-modality detection of SARS-CoV-2 in faecal donor samples for transplantation and in asymptomatic emergency surgical admissions

  Manzoor, S. E., Zaman, S., Whalley, C., Inglis, D., Bosworth, A., Kidd, M., Shabir, S., Quraishi, N., Green, C. A., Iqbal, T. & Beggs, A. D., 11 May 2021, In: F1000Research. 10, 373.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Fecal Microbiota Transplantation 70%
  • Dilution 54%
  • Tissue Donors 53%
  • Emergencies 52%
  118 Downloads (Pure)

• Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer

  Andrijes, R., Hejmadi, R. K., Pugh, M., Rajesh, S., Novitskaya, V., Ibrahim, M., Overduin, M., Tselepis, C., Middleton, G. W., Győrffy, B., Beggs, A. D. & Berditchevski, F., 28 Sept 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 39, 10 p., e2011411118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tetraspanins 100%
  • Colorectal Neoplasms 54%
  • Carcinogenesis 52%
  • ErbB Receptors 32%
  • Cetuximab 28%
  37 Downloads (Pure)

• The molecular landscape of well differentiated retroperitoneal liposarcoma

  Tyler, R., Dilworth, M. P., James, J., Blakeway, D., Stockton, J. D., Morton, D. G., Taniere, P., Gourevitch, D., Desai, A. & Beggs, A. D., Oct 2021, In: Journal of Pathology. 255, 2, p. 132-140 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Retroperitoneal liposarcoma 100%
  • Liposarcoma 77%
  • Mutation 33%
  • Chromosomes, Human, Pair 12 26%
  • Chromosomes, Human, Pair 6 26%
  77 Downloads (Pure)

• Ultra-low DNA Input into whole genome methylation assays and detection of oncogenic methylation and copy number variants in circulating tumour DNA

  Whalley, C., Payne, K., Domingo, E., Blake, A., Richman, S., Brooks, J., Batis, N., Spruce, R., Consortium, S. C., Mehanna, H., Nankivell, P. & Beggs, A., 19 Feb 2021, In: Epigenomes. 5, 1, 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Circulating Tumor DNA 100%
  • Oncogenic 97%
  • Methylation 62%
  • Genome 47%
  • DNA 38%
  158 Downloads (Pure)
• 2020

  A pilot integrative analysis of colonic gene expression, gut microbiota, and immune infiltration in primary sclerosing cholangitis-inflammatory bowel disease: association of disease with bile acid pathways

  Quraishi, M. N., Acharjee, A., Beggs, A. D., Horniblow, R., Tselepis, C., Gkoutos, G., Ghosh, S., Rossiter, A., Loman, N., van Schaik, W., Withers, D., Walters, J. R. F., Hirschfield, G. M. & Iqbal, T. H., Jul 2020, In: Journal of Crohn's & Colitis. 14, 7, p. 935-947 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sclerosing Cholangitis 100%
  • Bile Acids and Salts 81%
  • Gastrointestinal Microbiome 77%
  • Ulcerative Colitis 77%
  • Inflammatory Bowel Diseases 74%
  13 Citations (Scopus)

  273 Downloads (Pure)

• SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

  Shields, A., Faustini, S. E., Perez-Toledo, M., Jossi, S., Aldera, E., Allen, J. D., Al-Taei, S., Backhouse, C., Bosworth, A., Dunbar, L. A., Ebanks, D., Emmanuel, B., Garvey, M., Gray, J., Kidd, I. M., McGinnell, G., McLoughlin, D. E., Morley, G., O'Neill, J., Papakonstantinou, D., & 14 othersPickles, O., Poxon, C., Richter, M., Walker, E. M., Wanigasooriya, K., Watanabe, Y., Whalley, C., Zielinska, A. E., Crispin, M., Wraith, D. C., Beggs, A. D., Cunningham, A. F., Drayson, M. T. & Richter, A. G., 16 Nov 2020, In: Thorax. 75, 12, p. 1089-1094 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Seroepidemiologic Studies 75%
  • Health Personnel 58%
  • Cross-Sectional Studies 44%
  • Hospital Departments 21%
  45 Citations (Scopus)

  210 Downloads (Pure)

• Survival after traumatic brain injury improves with deployment of neurosurgeons: a comparison of US and UK military treatment facilities during the Iraq and Afghanistan conflicts

  Breeze, J., Bowley, D. M., Harrisson, S. E., Dye, J., Neal, C., Bell, R. S., Armonda, R. A., Beggs, A. D., DuBose, J., Rickard, R. F. & Powers, D. B., Apr 2020, In: Journal of Neurology Neurosurgery and Psychiatry. 91, 4, p. 359-365 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Military Facilities 100%
  • Afghanistan 82%
  • Iraq 79%
  • Neurosurgeons 74%
  • Traumatic Brain Injury 62%
  1 Citation (Scopus)

  141 Downloads (Pure)

• The transition from primary colorectal cancer to isolated peritoneal malignancy is associated with an increased tumour mutational burden

  Hallam, S., Stockton, J., Bryer, C., Whalley, C., Pestinger, V., Youssef, H. & Beggs, A. D., 3 Nov 2020, In: Scientific Reports. 10, 1, 18900.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tumor Burden 100%
  • Cytoreduction Surgical Procedures 90%
  • Colorectal Neoplasms 83%
  • Neoplasm Metastasis 64%
  • Drug Therapy 41%
  172 Downloads (Pure)

• Use of an integrated pan-cancer oncology enrichment next-generation sequencing assay to measure tumour mutational burden and detect clinically actionable variants

  Pestinger, V., Smith, M., Sillo, T., Findlay, J. M., Laes, J-F., Martin, G., Middleton, G., Taniere, P. & Beggs, A. D., Jun 2020, In: Molecular Diagnosis and Therapy. 24, 3, p. 339-349 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Whole Genome Sequencing 100%
  • High-Throughput Nucleotide Sequencing 82%
  • Tumor Burden 81%
  • Nucleotides 46%
  • Programmed Cell Death 1 Receptor 41%
  3 Citations (Scopus)

  270 Downloads (Pure)