Understanding the mechano-signalling role of the Z-disc in the pathogenesis of Hypertrophic Cardiomyopathy

Gehmlich, Katja (Principal Investigator)

Cardiovascular Sciences

Short title	Understanding the mechano-signalling role of the Z-disc in the pathogenesis of Hypertrophic Cardiomyopathy
Status	Active
Effective start/end date	1/09/24 → 28/12/28

Funding

British Heart Foundation

4 Article

Filamin C dimerisation is regulated by HSPB7
Wang, Z., Cao, G., Collier, M. P., Qiu, X., Broadway-Stringer, S., Šaman, D., Ng, J. Z. Y., Sen, N., Azad, A., Hooper, C., Zimmerman, J., McDonough, M. A., Brem, J., Rabe, P., Song, H., Alderson, T. R., Schofield, C. J., Bolla, J. R., Djinovic-Carugo, K. & Fürst, D. O. & 7 others, Warscheid, B., Degiacomi, M. T., Allison, T. M., Hochberg, G. K. A., Robinson, C. V., Gehmlich, K. & Benesch, J. L. P., 1 May 2025, In: Nature Communications. 16, 16 p., 4090.
Research output: Contribution to journal › Article › peer-review

Open Access
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HCM‐Associated MuRF1 Variants Compromise Ubiquitylation and Are Predicted to Alter Protein Structure
Chunthorng-Orn, J., Noureddine, M., Dawson, P., Lord, S. O., Ng, J., Boyton, L., Gehmlich, K., Mohammed, F. & Lai, Y.-C., 21 Apr 2025, In: International Journal of Molecular Sciences. 26, 8, 25 p., 3921.
Research output: Contribution to journal › Article › peer-review

Open Access
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Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease
Noureddine, M., Mikolajek, H., Morgan, N., Denning, C., Loughna, S., Gehmlich, K. & Mohammed, F., 7 Feb 2025, In: Journal of General Physiology. 157, 2, e202413684.
Research output: Contribution to journal › Article › peer-review

Open Access
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29 Downloads (Pure)