Understanding the interplay of enhancers, chromatin priming elements and signals regulating dynamic gene expression in development

Cazier, Jean-Baptiste (Co-Investigator)
Brown, James (Co-Investigator)
Bonifer, Conny (Principal Investigator)

Short title	Understanding the interplay of enhancers, chromatin priming elements and signals regulating dynamic gene expression in development
Status	Finished
Effective start/end date	1/10/18 → 2/08/22

Funding

Biotechnology & Biological Sciences Research Council

Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells
Ng, E. S., Sarila, G., Li, J. Y., Edirisinghe, H. S., Saxena, R., Sun, S., Bruveris, F. F., Labonne, T., Sleebs, N., Maytum, A., Yow, R. Y., Inguanti, C., Motazedian, A., Calvanese, V., Capellera-Garcia, S., Ma, F., Nim, H. T., Ramialison, M., Bonifer, C. & Mikkola, H. K. A. & 2 others, Stanley, E. G. & Elefanty, A. G., Aug 2025, In: Nature Biotechnology. 43, 8, p. 1274-1287
Research output: Contribution to journal › Article › peer-review

Open Access
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Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification
Maytum, A., Edginton-White, B., Keane, P., Cockerill, P. N., Cazier, J.-B. & Bonifer, C., Feb 2024, In: Life Science Alliance. 7, 2, 15 p., e202302363.
Research output: Contribution to journal › Article › peer-review

Open Access
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102 Downloads (Pure)
Identification and characterization of enhancer elements controlling cell type-specific and signalling dependent chromatin programming during hematopoietic development
Maytum, A., Edginton-White, B. & Bonifer, C., 25 Jun 2023, In: Stem Cell Investigation. 10, 15 p., 14.
Research output: Contribution to journal › Review article › peer-review

Open Access
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92 Downloads (Pure)