Understanding the function of PITX2 in the adult left atrium

2024

Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse

Sommerfeld, L. C., Holmes, A. P., Yu, T. Y., O'Shea, C., Kavanagh, D. M., Pike, J. M., Wright, T., Syeda, F., Aljehani, A., Kew, T., Cardoso, V. R., Kabir, S. N., Hepburn, C., Menon, P. R., Broadway‐Stringer, S., O'Reilly, M., Witten, A., Fortmueller, L., Lutz, S., Kulle, A., & 9 othersGkoutos, G. V., Pavlovic, D., Arlt, W., Lavery, G. G., Steeds, R., Gehmlich, K., Stoll, M., Kirchhof, P. & Fabritz, L., 12 Feb 2024, (E-pub ahead of print) In: The Journal of Physiology.

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2023

An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions

Chua, W., Cardoso, V. R., Guasch, E., Sinner, M. F., Al-Taie, C., Brady, P., Casadei, B., Crijns, H. J. G. M., Dudink, E. A. M. P., Hatem, S. N., Kääb, S., Kastner, P., Mont, L., Nehaj, F., Purmah, Y., Reyat, J. S., Schotten, U., Sommerfeld, L. C., Zeemering, S., Ziegler, A., & 3 othersGkoutos, G. V., Kirchhof, P. & Fabritz, L., 5 Oct 2023, In: Scientific Reports. 13, 1, 12 p., 16743.

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2022

Attaining sinus rhythm mediates improved outcome with early rhythm control therapy of atrial fibrillation: the EAST-AFNET 4 trial

Eckardt, L., Sehner, S., Suling, A., Borof, K., Breithardt, G., Crijns, H., Goette, A., Wegscheider, K., Zapf, A., Camm, J., Metzner, A. & Kirchhof, P., 21 Oct 2022, In: European Heart Journal. 43, 40, p. 4127-4144 18 p.

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Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide

O'Reilly, M., Sommerfeld, L. C., O'Shea, C., Broadway-Stringer, S., Andaleeb, S., Reyat, J. S., Kabir, S. N., Stastny, D., Malinova, A., Delbue, D., Fortmueller, L., Gehmlich, K., Pavlovic, D., Skryabin, B. V., Holmes, A. P., Kirchhof, P. & Fabritz, L., 12 Dec 2022, (E-pub ahead of print) In: EP Europace. euac218.

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High resolution optical mapping of cardiac electrophysiology in pre-clinical models

O’Shea, C., Winter, J., Kabir, S. N., O’Reilly, M., Wells, S. P., Baines, O., Sommerfeld, L. C., Correia, J., Lei, M., Kirchhof, P., Holmes, A. P., Fabritz, L., Rajpoot, K. & Pavlovic, D., Dec 2022, In: Scientific Data. 9, 1, 12 p., 135.

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Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death

Brady, P. F., Chua, W., Nehaj, F., Connolly, D. L., Khashaba, A., Purmah, Y. J. V., Ul-Qamar, M. J., Thomas, M. R., Varma, C., Schnabel, R. B., Zeller, T., Fabritz, L. & Kirchhof, P. F., 15 Feb 2022, In: Journal of the American Heart Association. 11, 4, e022833.

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2021

Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial

Metzner, A., Suling, A., Brandes, A., Breithardt, G., Camm, A. J., Crijns, H. J. G. M., Eckardt, L., Elvan, A., Goette, A., Haegeli, L. M., Heidbuchel, H., Kautzner, J., Kuck, K-H., Mont, L., Ng, A. A., Szumowski, L., Themistoclakis, S., van Gelder, I. C., Vardas, P., Wegscheider, K., & 2 othersWillems, S. & Kirchhof, P., 2 Sept 2021, (E-pub ahead of print) In: Europace. euab200.

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Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: a validation study

Chua, W., Law, J. P., Cardoso, V. R., Purmah, Y., Neculau, G., Jawad-Ul-Qamar, M., Russell, K., Turner, A., Tull, S. P., Nehaj, F., Brady, P., Kastner, P., Ziegler, A., Gkoutos, G. V., Pavlovic, D., Ferro, C. J., Kirchhof, P. & Fabritz, L., 3 Feb 2021, In: PLoS Medicine. 18, 2, e1003405.

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Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial

Willems, S., Borof, K., Brandes, A., Breithardt, G., Camm, A. J., Crijns, H. J. G. M., Eckardt, L., Gessler, N., Goette, A., Haegeli, L. M., Heidbuchel, H., Kautzner, J., Ng, G. A., Schnabel, R. B., Suling, A., Szumowski, L., Themistoclakis, S., Vardas, P., van Gelder, I. C., Wegscheider, K., & 1 othersKirchhof, P., 27 Aug 2021, (E-pub ahead of print) In: European Heart Journal. ehab593.

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2020

Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation

Piccini, J. P., Todd, D. M., Massaro, T., Lougee, A., Haeusler, K. G., Blank, B., De Bono, J. P., Callans, D. J., Elvan, A., Fetsch, T., Van Gelder, I., Gentlesk, P., Grimaldi, M., Hansen, J., Hindricks, G., Al-khalidi, H., Mont, L., Nielsen, J. C., Noelker, G., De Potter, T., & 6 othersScherr, D., Schotten, U., Themistoclakis, S., Vijgen, J., Di Biase, L. & Kirchhof, P., 12 Oct 2020, (E-pub ahead of print) In: Heart. 106, 24, p. 1919-1926

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2 Citations (Scopus)

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Predicting recurrent atrial fibrillation after catheter ablation: a systematic review of prognostic models

Dretzke, J., Chuchu, N., Agarwal, R., Herd, C., Chua, W. W. L., Fabritz, L., Bayliss, S., Kotecha, D., Deeks, J., Kirchhof, P. & Takwoingi, Y., 1 May 2020, In: Europace. 22, 5, p. 748–760

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11 Citations (Scopus)

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Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

Reyat, J. S., Chua, W., Cardoso, V. R., Witten, A., Kastner, P. M., Kabir, S. N., Sinner, M. F., Wesselink, R., Holmes, A. P., Pavlovic, D., Stoll, M., Kääb, S., Gkoutos, G. V., de Groot, J. R., Kirchhof, P. & Fabritz, L., 20 Aug 2020, In: JCI Insight. 5, 16, e139179.

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5 Citations (Scopus)

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Understanding the function of PITX2 in the adult left atrium

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