TRAIP ubiquitin ligase driving replisome disassembly

Gambus, Aga (Principal Investigator)

Cancer and Genomic Sciences

Short title	TRAIP ubiquitin ligase driving replisome disassembly
Status	Finished
Effective start/end date	1/12/19 → 30/11/23

Funding

Biotechnology & Biological Sciences Research Council

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS
Poovathumkadavil, D., Reynolds-Winczura, A., Skagia, A., Passaretti, P., Sadurni, M. M., Kingsley, G., Leitner, A., Saponaro, M. & Gambus, A., 22 Jul 2025, In: Nucleic Acids Research. 53, 13, 18 p., gkaf530.
Research output: Contribution to journal › Article › peer-review

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DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation
Kingsley, G., Skagia, A., Passaretti, P., Fernandez-Cuesta, C., Reynolds-Winczura, A., Koscielniak, K. & Gambus, A., 28 Aug 2023, (E-pub ahead of print) In: Nucleic Acids Research. gkad694.
Research output: Contribution to journal › Article › peer-review

Open Access
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The structural mechanism of dimeric DONSON in replicative helicase activation
Cvetković, M., Passaretti, P., Butryn, A., Reynolds-Winczura, A., Kingsley, G., Skagia, A., Fernandez Cuesta, C., Poovathumkadavil, D., George, R., Chauhan, A., Jhujh, S., Stewart, G., Gambus, A. & Costa, A., 16 Nov 2023, In: Molecular Cell. 83, 22, p. 4017-4031.e9 24 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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