The role of neutrophil serine proteases in vasculitic glomerulonephritis and potential as therapeutic targets

Research output

Research output per year 2007 2007 2011 2012 2014

• 10 Article

Research output per year

Research output per year

Search results

• 2014

  Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6–mediated crosstalk

  Kuravi, S. J., Mcgettrick, H. M., Satchell, S. C., Saleem, M. A., Harper, L., Williams, J. M., Rainger, G. E. & Savage, C. O. S., 2014, In: Journal of Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Podocytes 100%
  • Neutrophil Infiltration 92%
  • Endothelial Cells 60%
  • Interleukin-6 31%
  • Chemokine CXCL5 18%
  28 Citations (Scopus)

  341 Downloads (Pure)
• 2012

  Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction

  Kuravi, S. J., Bevins, A., Satchell, S. C., Harper, L., Williams, J. M., Rainger, G. E., Savage, C. O. S. & Tull, S. P., Dec 2012, In: Nephrology, Dialysis, Transplantation. 27, 12, p. 4331-8 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Serine Proteases 100%
  • Endothelium 78%
  • Neutrophils 69%
  • Myeloblastin 63%
  • P-Selectin 35%
  7 Citations (Scopus)

• PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells

  Tull, S. P., Bevins, A., Kuravi, S. J., Satchell, S. C., Al-Ani, B., Young, S. P., Harper, L., Williams, J. M., Rainger, G. E. & Savage, C. O. S., 29 Aug 2012, In: PLoS ONE. 7, 8, p. e43916

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Proteinase-Activated Receptors 100%
  • Myeloblastin 97%
  • blood coagulation factors 90%
  • elastase 82%
  • Pancreatic Elastase 79%
  11 Citations (Scopus)

  202 Downloads (Pure)
• 2011

  A dual role for diacylglycerol kinase generated phosphatidic acid in auto-antibody induced neutrophil exocytosis

  Holden, N., Savage, C., Young, S., Wakelam, M., Harper, L. & Williams, J., Nov 2011, In: Molecular Medicine. 17, 11-12, p. 1242-1252 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Diacylglycerol Kinase 100%
  • Phosphatidic Acids 90%
  • Exocytosis 76%
  • Antineutrophil Cytoplasmic Antibodies 73%
  • R 59022 53%
  12 Citations (Scopus)

• ANCA-associated vasculitis is linked to carriage of the Z allele of alpha(1) antitrypsin and its polymers

  Morris, H., Morgan, M., Turner, A., Smith, S., Ekeowa, UI., Herrmann, K., Holle, JU., Guillevin, L., Lomas, DA., Perez, J., Pusey, CD., Salama, AD., Stockley, R., Wieczorek, S., McKnight, AJ., Maxwell, AP., Miranda, E., Williams, J., Savage, C. & Harper, L., 1 Oct 2011, In: Annals of the Rheumatic Diseases. 70, 10, p. 1851-1856 6 p.

  Research output: Contribution to journal › Article

  • alpha 1-Antitrypsin 100%
  • Antineutrophil Cytoplasmic Antibodies 95%
  • Trypsin Inhibitor 91%
  • Vasculitis 78%
  • Polymers 67%
  53 Citations (Scopus)

• ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process.

  Holden, N., Williams, J., Morgan, M., Challa, A., Gordon, J., Pepper, RJ., Salama, AD., Harper, L. & Savage, C., 1 Dec 2011, In: Annals of the Rheumatic Diseases. 70, 12, p. 2229-33 5 p.

  Research output: Contribution to journal › Article

  • B-Cell Activating Factor 100%
  • Antineutrophil Cytoplasmic Antibodies 86%
  • Cell Viability 68%
  • Neutrophils 53%
  • B-Lymphocytes 52%
  61 Citations (Scopus)

• Immunoglobulin subclass determines ability of immunoglobulin (Ig)G to capture and activate neutrophils presented as normal human IgG or disease-associated anti-neutrophil cytoplasm antibody (ANCA)-IgG.

  Pankhurst, T., Nash, G., Williams, J., Colman, R., Hussain, A. & Savage, C., 10 Mar 2011, In: Clinical & Experimental Immunology.

  Research output: Contribution to journal › Article

  • Immunoglobulins 100%
  • Cytoplasm 92%
  • Neutrophils 88%
  • Immunoglobulin G 85%
  • Aptitude 77%
  15 Citations (Scopus)
• 2009

  Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fc gamma receptors

  Hussain, A., Pankhurst, T., Goodall, D., Colman, R., Jefferis, R., Savage, C. & Williams, J., 1 Oct 2009, In: Immunology. 128, 2, p. 236-244 9 p.

  Research output: Contribution to journal › Article

  • IgG Receptors 100%
  • Antineutrophil Cytoplasmic Antibodies 94%
  • Myeloblastin 67%
  • Neutrophils 58%
  • Immunoglobulin G 56%
  34 Citations (Scopus)
• 2007

  Antineurtrophil cytoplasm antibody-stimulated neutrophil adhesion is dependent upon diacylglycerol kinase-catalysed phosphatidic acid formation

  Williams, J., Pettitt, T., Powell, W., Grove, J., Savage, C. & Wakelam, M., 1 Apr 2007, In: Journal of the American Society of Nephrology. 18, p. 1112-20 9 p.

  Research output: Contribution to journal › Article

  • Diacylglycerol Kinase 100%
  • Phosphatidic Acids 90%
  • Antineutrophil Cytoplasmic Antibodies 85%
  • Cytoplasm 55%
  • Neutrophils 53%
  32 Citations (Scopus)

• Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils

  Colman, R., Hussain, A., Goodall, M., Young, S., Pankhurst, T., Lu, X., Jefferis, R., Savage, C. & Williams, J., 1 May 2007, In: Annals of the Rheumatic Diseases. 66, 5, p. 676-82 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Myeloblastin 100%
  • Epitope 70%
  • Neutrophils 54%
  • Immunoglobulin G 52%
  • Antineutrophil Cytoplasmic Antibodies 52%
  13 Citations (Scopus)