The Role of Fibroblasts in the Regulation of Leucocyte Retention in Chronic Inflammation

Research output

Research output per year 2005 2006 2007 2008 2009

• 27 Article
• 2 Letter
• 1 Review article

Research output per year

Research output per year

Search results

• 2009

  Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells

  McGettrick, H., Smith, E., Filer, A., Kissane, S., Salmon, M., Buckley, C., Rainger, G. & Nash, G., 1 Jan 2009, In: European Journal of Immunology. 39, 1, p. 113-25 13 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Fibroblasts 100%
  • Endothelial Cells 99%
  • Lymphocytes 93%
  • Synovial Membrane 67%
  • Cytokines 59%
  66 Citations (Scopus)

  177 Downloads (Pure)

• Mesenchymal stem cells: the fibroblasts' new clothes?

  Haniffa, M. A., Collin, M. P., Buckley, C. & Dazzi, F., 1 Feb 2009, In: Haematologica. 94, 2, p. 258-263 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Clothing 100%
  • Mesenchymal Stem Cells 76%
  • Stromal Cells 68%
  • Fibroblasts 63%
  • Transcriptome 15%
  262 Citations (Scopus)

  159 Downloads (Pure)
• 2008

  Anti-collagen type II antibodies in patients with very early synovitis

  Raza, K., Mullazehi, M., Salmon, M., Buckley, C. & Ronnelid, J., 1 Sept 2008, In: Annals of the Rheumatic Diseases. 67, 9, p. 1354-1355 2 p.

  Research output: Contribution to journal › Letter
  8 Citations (Scopus)

  1 Downloads (Pure)

• A role for the integrin α6 β1 in the differential distribution of CD4 and CD8 T-cell subsets within the rheumatoid synovium

  Haworth, O., Hardie, D., Burman, A., Rainger, G., Eksteen, J., Adams, D., Salmon, M., Nash, G. & Buckley, C., 4 Apr 2008, In: Rheumatology. 47, 9, p. 1329-1334 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Synovial Membrane 100%
  • T-Lymphocyte Subsets 91%
  • Integrins 80%
  • T-Lymphocytes 52%
  • Synovial Fluid 32%
  13 Citations (Scopus)

• Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis

  Scheel-Toellner, D., Raza, K., Assi, L., Pilling, D., Ross, E., Lee, W-Y., Curnow, S., Buckley, C., Akbar, AN., Lord, J. & Salmon, M., 1 Jan 2008, In: Apoptosis. 23, 1, p. 109-17 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Antiapoptotic 100%
  • Caspases 85%
  • Cytokines 52%
  • T-Lymphocytes 52%
  • Apoptosis 51%
  5 Citations (Scopus)

• Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium

  Smith, E., McGettrick, H., Stone, MA., Shaw, JS., Middleton, J., Nash, G., Buckley, C. & Rainger, G., 1 Jul 2008, In: Arthritis & Rheumatism. 58, 7, p. 1968-1973 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chemokine CXCL5 100%
  • Antigen Receptors 68%
  • Synovial Membrane 64%
  • Neutrophil Infiltration 62%
  • Chemokines 51%
  38 Citations (Scopus)

  152 Downloads (Pure)

• Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells

  D'Acquisto, F., Paschalidis, N., Raza, K., Buckley, C., Flower, RJ. & Perretti, M., 29 Jan 2008, In: Rheumatology. 47, 5, p. 636-639 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Annexins 100%
  • Glucocorticoids 68%
  • Rheumatoid Arthritis 62%
  • T-Lymphocytes 46%
  • Dexamethasone 38%
  33 Citations (Scopus)

  3 Downloads (Pure)

• Immune interactions in hepatic fibrosis

  Holt, A., Salmon, M., Buckley, C. & Adams, D., 1 Nov 2008, In: Clinics in Liver Disease. 12, 4, p. 861-882

  Research output: Contribution to journal › Article › peer-review

  • Fibrosis 100%
  • Cicatrix 87%
  • Liver 69%
  • Inflammation 59%
  • Immune System 53%
  76 Citations (Scopus)

• Local and systemic glucocorticoid metabolism in inflammatory arthritis

  Hardy, R., Rabbitt, E., Filer, A., Emery, P., Hewison, M., Stewart, P., Gittoes, N., Buckley, C., Raza, K. & Cooper, M., 1 Jan 2008, In: Annals of the Rheumatic Diseases. 67, 9, p. 1204-1210 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Glucocorticoid 100%
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 72%
  • Glucocorticoids 70%
  • Arthritis 68%
  • Pharmacological Metabolism 60%
  88 Citations (Scopus)

  1 Downloads (Pure)

• Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells

  Chan, A., Filer, A., Parsonage, G., Kollnberger, S., Gundle, R., Buckley, C. & Bowness, P., 1 Mar 2008, In: Arthritis & Rheumatism. 58, 3, p. 707-717 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spondylarthritis 100%
  • Synoviocytes 82%
  • Natural Killer Cells 56%
  • Rheumatoid Arthritis 50%
  • Fibroblasts 45%
  33 Citations (Scopus)

• Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

  Parsonage, G., Filer, A., Bik, M., Hardie, D., Lax, S., Howlett, K., Church, L., Raza, K., Wong, SH., Trebilcock, E., Scheel-Toellner, D., Salmon, M., Lord, J. & Buckley, C., 1 Jan 2008, In: Arthritis Research & Therapy. 10, 2, p. R47

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-17 100%
  • Granulocyte-Macrophage Colony-Stimulating Factor 99%
  • Neutrophils 73%
  • Fibroblasts 70%
  • Tumor Necrosis Factor-alpha 67%
  57 Citations (Scopus)

  162 Downloads (Pure)

• Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow

  Palendira, U., Chinn, R., Raza, W., Piper, K., Pratt, G., Machado, L., Bell, A., Khan, N., Hislop, A., Steyn, R., Rickinson, A., Buckley, C. & Moss, P., 15 Oct 2008, In: Blood. 112, 8, p. 3293-302 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Partition 97%
  • Antigen 82%
  • Bone Marrow 71%
  • Viruses 65%
  62 Citations (Scopus)

  6 Downloads (Pure)
• 2007

  CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis

  Manzo, A., Bugatti, S., Caporali, R., Prevo, R., Jackson, DG., Uguccioni, M., Buckley, C., Montecucco, C. & Pitzalis, C., 14 Sept 2007, In: The American Journal of Pathology. 171, 5, p. 1549-1562 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Venules 100%
  • Tertiary Lymphoid Structures 93%
  • T-Lymphocytes 34%
  • Lymphatic Vessels 33%
  • Inflammation 32%
  70 Citations (Scopus)

• CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair

  Lax, S., Hou, T., Jenkinson, E., Salmon, M., Macfadyen, R., Isacke, CM., Anderson, G., Cunningham, A. & Buckley, C., 24 Jul 2007, In: FEBS Letters. 581, 18, p. 3550-3556 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoid Tissue 100%
  • Stromal Cells 93%
  • Marker 81%
  • Pericytes 37%
  • Salmonella 32%
  41 Citations (Scopus)

  8 Downloads (Pure)

• Delay in presentation to primary care physicians is the main reason why patients with rheumatoid arthritis are seen late by rheumatologists

  Kumar, K., Daley, E., Carruthers, D., Situnayake, R., Gordon, C., Grindulis, K., Buckley, C., Khattak, F. & Raza, K., 27 Jun 2007, In: Rheumatology. 46, p. 1438-40 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Rheumatologists 100%
  • Primary Care Physicians 86%
  • Rheumatoid Arthritis 67%
  • Secondary Care 44%
  • Primary Health Care 21%
  104 Citations (Scopus)

  21 Downloads (Pure)

• Fibroblasts as novel therapeutic targets in chronic inflammation

  Essex, S., Hou, T., Lax, S., Filer, A., Salmon, M. & Buckley, C., 29 Oct 2007, In: British Journal of Pharmacology. 153, S1, p. S241-S246

  Research output: Contribution to journal › Article › peer-review

  • Fibroblasts 100%
  • Inflammation 79%
  • Chronic Disease 49%
  • Anti-Inflammatory Agents 49%
  • Tropism 40%
  127 Citations (Scopus)

• Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

  McGettrick, H., Filer, A., Rainger, G., Buckley, C. & Nash, G., 1 Oct 2007, In: Biochemical Society Transactions. 35, 5, p. 1161-1162 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Communication 100%
  • Leukocytes 87%
  • Endothelial Cells 81%
  • Flow 70%
  • Environment 62%
  7 Citations (Scopus)

• Resolution of inflammation: state of the art, definitions and terms

  Sehran, CN., Brain, SD., Buckley, C., Gilroy, DW., Haslett, C., O'Neill, LAJ., Perretti, M., Rossi, AG. & Wallace, JL., 1 Feb 2007, In: FASEB Journal. 21, 2, p. 325-332 8 p.

  Research output: Contribution to journal › Article

  • Antiinflammatory 100%
  • Agonist 99%
  • Inflammation 61%
  • Anti-Inflammatory Agents 19%
  • Pharmacology 17%
  774 Citations (Scopus)

• Serum amyloid P and fibrosis in systemic sclerosis: comment on the article by Tennent et al

  Pilling, D., Buckley, C., Salmon, M. & Gomer, RH., 1 Dec 2007, In: Arthritis & Rheumatism. 56, 12, p. 4229 1 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Skin cancer in psoriatic arthritis treated with anti-TNF therapy

  Sheppard, J., Raza, K. & Buckley, C., 27 Aug 2007, In: The Journal of Rheumatology. 46, 10, p. 1622-1623 2 p.

  Research output: Contribution to journal › Letter

  • Psoriatic Arthritis 100%
  • Skin Neoplasms 85%
  • Hormones 58%
  • Carrier Proteins 23%
  • Binding Sites 21%
  12 Citations (Scopus)
• 2006

  Annexin-1 modulates T-cell activation and differentiation

  D'Aqcquisto, F., Merghani, A., Lecona, E., Rosignoli, G., Raza, K., Buckley, C., Flower, RJ. & Perretti, M., 5 Oct 2006, In: Blood. 109, 3, p. 1095-1102 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Annexins 100%
  • Cell Differentiation 60%
  • T-Lymphocytes 46%
  • Antiinflammatory 35%
  • Protein 30%
  103 Citations (Scopus)

  12 Downloads (Pure)

• Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium

  McGettrick, H., Lord, J., Wang, K-Q., Rainger, G., Buckley, C. & Nash, G., 13 Jan 2006, In: Journal of Leukocyte Biology. 79, 4, p. 779-788 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokines 100%
  • Human Umbilical Vein Endothelial Cells 95%
  • Endothelium 94%
  • Neutrophils 83%
  • Cytokines 66%
  37 Citations (Scopus)

• Differential expression, function and response to inflammatory stimuli of 11 beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation

  Hardy, R., Filer, A., Cooper, M., Parsonage, G., Raza, K., Hardie, D., Rabbitt, E., Stewart, P., Buckley, C. & Hewison, M., 17 Jun 2006, In: Arthritis Research & Therapy. 8, 4, R108.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 100%
  • Fibroblasts 49%
  • Inflammation 39%
  • Bone Marrow 15%
  • Glucocorticoids 14%
  73 Citations (Scopus)

  144 Downloads (Pure)

• Differential leucocyte subset survival mediated by synovial, bone marrow and skin fibroblasts in rheumatoid arthritis: site specific versus activation dependent survival of T cells and neutrophils

  Filer, A., Parsonage, G., Smith, E., Osborne, C., Thomas, A., Curnow, S., Rainger, G., Raza, K., Nash, G., Lord, J., Salmon, M. & Buckley, C., 1 Jul 2006, In: Arthritis & Rheumatism. 54, 7, p. 2096-2108 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Rheumatoid Arthritis 100%
  • Leukocytes 95%
  • Neutrophils 94%
  • Fibroblasts 89%
  • Bone Marrow 88%
  69 Citations (Scopus)

  4 Downloads (Pure)

• Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis

  Raza, K., Scheel-Toellner, D., Lee, C., Pilling, D., Curnow, S., Falciani, F., Trevino-Alvarado, V., Kumar, K., Lord, J., Gordon, C., Buckley, C. & Salmon, M., 1 Jan 2006, In: Arthritis Research & Therapy. 8, 4, R120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Synovial Fluid 100%
  • Rheumatoid Arthritis 72%
  • Leukocytes 69%
  • Apoptosis 53%
  • Arthritis 51%
  67 Citations (Scopus)

  141 Downloads (Pure)

• Targeting the stromal microenvironment in chronic inflammation

  Filer, A., Pitzalis, C. & Buckley, C., 1 Aug 2006, In: Current Opinion in Pharmacology. 6, p. 393-400 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antiinflammatory 100%
  • Inflammation 61%
  • Stromal Cells 35%
  • Environment 29%
  • Anti-Inflammatory Agents 25%
  29 Citations (Scopus)

  180 Downloads (Pure)

• Treating very early rheumatoid arthritis

  Raza, K., Buckley, C., Salmon, M. & Buckley, C., 1 Oct 2006, In: Best Practice & Research: Clinical Rheumatology. 20, 5, p. 849-863 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Rheumatoid Arthritis 100%
  • Antirheumatic Agents 28%
  • Synovitis 28%
  • Synovial Membrane 28%
  • Immunosuppressive Agents 20%
  94 Citations (Scopus)

  19 Downloads (Pure)
• 2005

  A novel mechanism of neutrophil recruitment in a co-culture model of the rheumatoid synovium

  Lally, F., Smith, E., Filer, A., Stone, MA., Shaw, JS., Nash, G., Buckley, C. & Rainger, G., 1 Nov 2005, In: Arthritis & Rheumatism. 52, 11, p. 3460-9 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Synovial Membrane 100%
  • Neutrophil Infiltration 97%
  • Coculture Techniques 85%
  • Neutrophils 67%
  • Fibroblasts 52%
  88 Citations (Scopus)

  196 Downloads (Pure)

• Identification of phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration

  Buckley, C., Ross, E., McGettrick, H., Osborne, C., Howarth, OJ., Schmutz, C., Stone, P., Salmon, M., Matharu, N., Vohra, R., Nash, G. & Rainger, G., 19 Dec 2005, In: Journal of Leukocyte Biology. 79, 2, p. 303-11 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophils 100%
  • Interleukin-8A Receptors 88%
  • Population 49%
  • Phenotype 23%
  • methionyl-leucyl-phenylalanine 18%
  198 Citations (Scopus)

• Interaction between integrin α₉β₁ and Vascular Cell Adhesion Molecule-1 (VCAM-1) inhibits neutrophil apoptosis: cross-talk between integrin and cytokine signalling pathways

  Ross, E., Douglas, M., Wong, S., Ross, E., Curnow, S., Nash, G., Rainger, G., Scheel-Toellner, D., Lord, J., Salmon, M. & Buckley, C., 13 Oct 2005, In: Blood. 107, 3, p. 1178-1183 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Antiapoptotic 100%
  • Vascular Cell Adhesion Molecule-1 81%
  • Protein Synthesis 73%
  • Integrins 66%
  • Neutrophils 55%
  40 Citations (Scopus)

  28 Downloads (Pure)