The impact of non-histone protein methylation by set1a in maintaining genome stability and preventing disease

Higgs, Martin (Principal Investigator)

Cancer and Genomic Sciences

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2025
SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells
Sweatman, E., Bayley, R., Selemane, R. & Higgs, M., 3 May 2025, In: British Journal of Cancer. 132, p. 690-702 13 p.
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2023
New perspectives on epigenetic modifications and PARP inhibitor resistance in HR-deficient cancers
Bayley, R., Sweatman, E. & Higgs, M., 4 Jan 2023, In: Cancer drug resistance (Alhambra, Calif.). 6, p. 35-44 10 p.
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2022
H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
Bayley, R., Borel, V., Moss, R., Sweatman, E., Ruis, P., Ormrod, A., Goula, A., Mottram, R., Stanage, T., Hewitt, G., Saponaro, M., Stewart, G., Boulton, S. & Higgs, M., 19 May 2022, In: Molecular Cell. 82, 10, p. 1924-1939.e10 26 p.
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2020
Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome
Kummerling, J., Stremmelaar, D. E., Raun, N., Reijnders, M. R. F., Willemsen, M. H., Ruiterkamp-Versteeg, M., Schepens, M., Man, C. C. O., Gilissen, C., Cho, M. T., McWalter, K., Sinnema, M., Wheless, J. W., Simon, M. E. H., Genetti, C. A., Casey, A. M., Terhal, P. A., van der Smagt, J. J., van Gassen, K. L. I. & Joset, P. & 23 others, Bahr, A., Steindl, K., Rauch, A., Keller, E., Raas-Rothschild, A., Koolen, D. A., Agrawal, P. B., Hoffman, T. L., Powell-Hamilton, N. N., Thiffault, I., Engleman, K., Zhou, D., Bodamer, O., Hoefele, J., Riedhammer, K. M., Schwaibold, E. M. C., Tasic, V., Schubert, D., Top, D., Pfundt, R., Higgs, M., Kramer, J. M. & Kleefstra, T., 28 Apr 2020, In: Molecular Psychiatry.
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Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability
The COMPLEXO Network, 3 Aug 2020, In: Journal of Clinical Investigation. 130, 8, p. 4069-4080 12 p.
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4 Citations (Scopus)

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The impact of non-histone protein methylation by set1a in maintaining genome stability and preventing disease

Research output

Search results

2025

SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells

2023

New perspectives on epigenetic modifications and PARP inhibitor resistance in HR-deficient cancers

2022

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

2020

Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome

Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability