Research output per year
Research output per year
Research output
- 16 Article
- 16 results
Search results
-
2015
Akt and mitogen-activated protein kinase enhance C-type lectin-like receptor 2-mediated platelet activation by inhibition of glycogen synthase kinase 3α/β
Moroi, A. J. & Watson, S. P., 1 Jun 2015, In: Journal of Thrombosis and Haemostasis. 13, 6, p. 1139–1150Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)159 Downloads (Pure) -
Fibrin activates GPVI in human and mouse platelets
Alshehri, O. M., Hughes, C. E., Montague, S., Watson, S. K., Frampton, J., Bender, M. & Watson, S. P., 24 Sept 2015, In: Blood. 126, 13, p. 1601-1608 8 p.Research output: Contribution to journal › Article › peer-review
Open Access125 Citations (Scopus) -
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets
Hitchcock, J. R., Cook, C. N., Bobat, S., Ross, E. A., Flores-Langarica, A., Lowe, K. L., Khan, M., Dominguez Medina, C., Lax, S., Carvalho-Gaspar, M., Hubscher, S., Rainger, G., Cobbold, M., Buckley, C. D., Mitchell, T. J., Mitchell, A., Jones, N., Van Rooijen, N., Kirchhofer, D., Henderson, I. R., & 3 others, 16 Nov 2015, In: Journal of Clinical Investigation. 125, 12, p. 4429–4446Research output: Contribution to journal › Article › peer-review
95 Citations (Scopus)102 Downloads (Pure) -
Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich Syndrome protein and ARP2/3 complex
Poulter, N., Pollitt, A., Davies, A., Malinova, D., Rappoport, J., Nash, G., Hannon, M., Pikramenou, Z., Hartwig, J. H., Thrasher, A. J., Watson, S., Thomas, S. & Owen, D., 1 Jun 2015, In: Nature Communications. 6, 7254.Research output: Contribution to journal › Article › peer-review
Open AccessFile56 Citations (Scopus)228 Downloads (Pure) -
Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling
Navarro-núñez, L., Pollitt, A. Y., Lowe, K., Latif, A., Nash, G. B. & Watson, S. P., May 2015, In: Thrombosis and Haemostasis. 113, 5, p. 1109-1120Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)309 Downloads (Pure) -
Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development
Lowe, K. L., Finney, B. A., Deppermann, C., Hägerling, R., Gazit, S. L., Frampton, J., Buckley, C., Camerer, E., Nieswandt, B., Kiefer, F. & Watson, S. P., 11 Jun 2015, In: Blood. 125, 24, p. 3769-3777 9 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Citations (Scopus) -
SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice
Cherpokova, D., Bender, M., Morowski, M., Kraft, P., Schuhmann, M. K., Akbar, S. M., Sultan, C. S., Hughes, C. E., Kleinschnitz, C., Stoll, G., Dragone, L. L., Watson, S. P., Tomlinson, M. G. & Nieswandt, B., 1 Jan 2015, In: Blood. 125, 1, p. 185-194 10 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Citations (Scopus) -
2014
Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option : use of 96-well Optimul assay
Lordkipanidze, M., Lowe, G. C., Kirkby, N. S., Chan, M. V., Lundberg, M. H., Morgan, N. V., Bem, D., Nisar, S. P., Leo, V. C., Jones, M. L., Mundell, S. J., Daly, M. E., Mumford, A. D., Warner, T. D. & Watson, S. P., 20 Feb 2014, In: Blood. 123, 8, p. e11-e22Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (Scopus)688 Downloads (Pure) -
CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP
Borgognone, A., Navarro-Nunez, L., Correia, J. N., Pollitt, A. Y., Thomas, S. G., Eble, J. A., Pulcinelli, F. M., Madhani, M. & Watson, S. P., Apr 2014, In: Journal of Thrombosis and Haemostasis. 12, 4, p. 550-559 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)173 Downloads (Pure) -
Syk and Src family kinases regulate C-type lectin receptor 2 (clec-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells
Pollitt, A. Y., Poulter, N. S., Gitz, E., Navarro-Nunez, L., Wang, Y-J., Hughes, C. E., Thomas, S. G., Nieswandt, B., Douglas, M. R., Jackson, D. G., Dustin, M. L., Watson, S. P. & Owen, D., 26 Dec 2014, In: Journal of Biological Chemistry. 289, 52, p. 35695-35710 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)209 Downloads (Pure) -
2013
Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice
Bender, M., May, F., Lorenz, V., Thielmann, I., Hagedorn, I., Finney, B. A., Vogtle, T., Remer, K., Braun, A., Bosl, M., Watson, S. P. & Nieswandt, B., 1 May 2013, In: Arteriosclerosis Thrombosis and Vascular Biology. 33, 5, p. 926-934Research output: Contribution to journal › Article › peer-review
Open AccessFile87 Citations (Scopus)894 Downloads (Pure) -
Critical role for an acidic amino acid region in platelet signaling by the hemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2)
Hughes, C., Sinha, U., Pandey, A., Eble, J. A., O'Callaghan, CA. & Watson, S. P., 15 Feb 2013, In: Journal of Biological Chemistry. 288, 7, p. 5127-5135Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)200 Downloads (Pure) -
Utility of the ISTH bleeding assessment tool in predicting platelet defects in participants with suspected inherited platelet function disorders
Lowe, G. C., Lordkipanidzé, M. & Watson, S. P., Sept 2013, In: Journal of Thrombosis and Haemostasis. 11, 9, p. 1663-1668Research output: Contribution to journal › Article › peer-review
Open AccessFile90 Citations (Scopus)579 Downloads (Pure) -
2012
G6f-like is an ITAM-containing collagen receptor in thrombocytes
Hughes, C. E., Radhakrishnan, U. P., Lordkipanidzé, M., Egginton, S., Dijkstra, J. M., Jagadeeswaran, P., Watson, S. P. & Katz, E. (ed.), 21 Dec 2012, In: PLoS ONE. 7, 12, e52622.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)158 Downloads (Pure) -
2010
CLEC-2 activates Syk through dimerization
Hughes, C., Pollitt, A., Mori, J., Eble, JA., Tomlinson, M., Hartwig, JH., O'Callaghan, CA., Futterer, K. & Watson, S., 12 Feb 2010, In: Blood. 115, 14, p. 2947-2955Research output: Contribution to journal › Article › peer-review
Open AccessFile110 Citations (Scopus)269 Downloads (Pure) -
Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac
Pollitt, A., Grygielska, B., Leblond, B., Desire, L., Eble, JA. & Watson, S., 1 Apr 2010, In: Blood. 115, 14, p. 2938-2946 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Citations (Scopus)315 Downloads (Pure)