Targeting the autophagy-NAD axis in rare early-onset neurodegenerative diseases

Barrett, Timothy (Co-Investigator)
Sarkar, Sovan (Principal Investigator)

Cancer and Genomic Sciences

Short title	Targeting the autophagy-NAD axis in rare early-onset neurodegenerative diseases
Status	Active
Effective start/end date	1/10/24 → 30/09/27

Funding

Medical Research Council

2 Article
2 Review article

DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation
Niven, J., Kucuk, S., Gope, A., Certo, M., Cassidy, F. C., Arana Echarri, A., Ali, S., Ladoukakis, E., Vidali, S., Macchi, C., Amir, S. S., Bergin, R., Davies, S., Perkin, O. J., Smith, J., Cucchi, D., Heneghan, H., Wijesinghe, S., Jenkins, B. J. & Baig, S. & 20 others, Mahony, C., Chidomere, C., Sarkar, S., Nicolaou, A., Caamaño, J., Croft, A., Davies, E., Thompson, D., O’Shea, D., Jones, S. W., Duggal, N. A., Ruscica, M., Makarova, M., Jones, N., Da Silva Xavier, G., Geberhiwot, T., Turner, J. E., Hogan, A. E., Nedjai, B. & Mauro, C., 27 Apr 2026, (E-pub ahead of print) In: EMBO Reports. 27 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
17 Downloads (Pure)
From autophagy–lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders
Kawachi, Y., Kocak, G., Korolchuk, V. I., Kataura, T. & Sarkar, S., 18 May 2026, In: Frontiers in Neuroscience. 20, 9 p., 1857866.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
3 Downloads (Pure)
Autophagy is required for the development and functionality of lacrimal gland-like organoids
Kocak, G., Korsgen, M. E., Amores, L. F., Sun, C., Ceylan, M., Ghazwani, A., Kandirici, M., Zatyka, M., Seranova, E., Acharjee, A., Barrett, T., Yuksel, B., Mardinoglu, A., Güven, S. & Sarkar, S., 18 Dec 2025, (E-pub ahead of print) In: Stem Cell Reports.
Research output: Contribution to journal › Article › peer-review

Open Access
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5 Downloads (Pure)

Targeting the autophagy-NAD axis in rare early-onset neurodegenerative diseases

Project Details

Funding

Fingerprint

DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation

From autophagy–lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders

Autophagy is required for the development and functionality of lacrimal gland-like organoids

Targeting the autophagy-NAD axis in rare early-onset neurodegenerative diseases

Project Details

Funding

Fingerprint

Research output

DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation

From autophagy–lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders

Autophagy is required for the development and functionality of lacrimal gland-like organoids