Project Details
| Short title | SeluDex: A phase IB/II open label study of the MEK-inhibitor selumetinib in combination with dexamethasone for paediatric and adult patients with 2nd relapsed precursor B- or T-ALL |
|---|---|
| Status | Finished |
| Effective start/end date | 1/10/16 → 31/12/24 |
Funding
- INNOVATIVE THERAPIES FOR CHILDREN WITH CANCER (ITCC)
- Astra Zeneca Uk Limited
- Cancer Research UK
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Responses can be achieved with a combination of the MEK inhibitor selumetinib and dexamethasone in patients with relapsed/refractory RAS-pathway mutated acute lymphoblastic leukemia: Results of a parallel cohort, dose-finding and expansion phase I/II trial
Vormoor, B., Savage, J., Kristunas, C., Johnson, S., Blanco, M. N. F., Shenton, G., Lancaster, D., Castleton, A., Fielding, A. K., Latif, A.-L., Morley, N., Strullu, M., Tuckuviene, R., Kearns, P., Jennings, C., Barnett, S., Veal, G. J., Irving, J., Billingham, L. & Menne, T. & 1 others, , Jun 2026, In: EJC Paediatric Oncology. 7, 10 p., 100489.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial
Menne, T., Slade, D., Savage, J., Johnson, S., Irving, J., Kearns, P., Plummer, R., Shenton, G., Veal, G. J., Vormoor, B., Vormoor, J. & Billingham, L., 4 Mar 2022, In: BMJ open. 12, 3, 12 p., e059872.Research output: Contribution to journal › Article › peer-review
Open AccessFile97 Downloads (Pure) -
Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial
Menne, T., Slade, D., Savage, J., Johnson, S., Irving, J. A. E., Kearns, P. R., Plummer, R., Shenton, G., Veal, G. J., Vormoor, B., Vormoor, J. & Billingham, L., 25 Oct 2021, medRxiv.Research output: Working paper/Preprint › Preprint