Revealing anti-tumour T cell recruitment and recirculation in vivo to optimise therapeutic intervention.

Withers, David (Principal Investigator)

Immunology and Immunotherapy

Short title	Revealing anti-tumour T cell recruitment and recirculation in vivo to optimise therapeutic intervention.
Status	Finished
Effective start/end date	1/02/19 → 31/01/22

Funding

Cancer Research Uk

6 Article

Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Dean, I., Lee, C. Y. C., Tuong, Z. K., Li, Z., Tibbitt, C. A., Willis, C., Gaspal, F., Kennedy, B. C., Matei-Rascu, V., Fiancette, R., Nordenvall, C., Lindforss, U., Baker, S. M., Stockmann, C., Sexl, V., Hammond, S. A., Dovedi, S. J., Mjösberg, J., Hepworth, M. R., Carlesso, G., & 2 othersClatworthy, M. R. & Withers, D. R., 24 Jan 2024, In: Nature Communications. 15, 1, 18 p., 683.
Research output: Contribution to journal › Article › peer-review

Open Access
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24 Downloads (Pure)
Tumour-retained activated CCR7⁺ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity
Lee, C. Y. C., Kennedy, B. C., Richoz, N., Dean, I., Tuong, Z. K., Gaspal, F., Li, Z., Willis, C., Hasegawa, T., Whiteside, S. K., Posner, D. A., Carlesso, G., Hammond, S. A., Dovedi, S. J., Roychoudhuri, R., Withers, D. R. & Clatworthy, M. R., 24 Jan 2024, In: Nature Communications. 15, 1, 18 p., 682.
Research output: Contribution to journal › Article › peer-review

Open Access
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44 Downloads (Pure)
Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3
Tachó-Piñot, R., Stamper, C. T., King, J. A., Matei-Rascu, V., Richardson, E., Li, Z., Roberts, L. B., Bassett, J. W., Melo-Gonzalez, F., Fiancette, R., Lin, I-H., Dent, A., Harada, Y., Finlay, C., Mjösberg, J., Withers, D. R. & Hepworth, M. R., 28 Nov 2023, In: Cell Reports. 42, 11, 22 p., 113425.
Research output: Contribution to journal › Article › peer-review

Open Access
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21 Downloads (Pure)

Revealing anti-tumour T cell recruitment and recirculation in vivo to optimise therapeutic intervention.

Project Details

Funding

Fingerprint

Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity

Tumour-retained activated CCR7⁺ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity

Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3

Revealing anti-tumour T cell recruitment and recirculation in vivo to optimise therapeutic intervention.

Project Details

Funding

Fingerprint

Research output

Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity

Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity

Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3

Tumour-retained activated CCR7⁺ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity