Pseudohypoxia-led identification of metabolic vulnerabilities in hypoxic tumours to improve patient outcomes

Tennant, Daniel (Principal Investigator)
Ludwig, Christian (Co-Investigator)

Metabolism and Systems Science

Short title	Pseudohypoxia-led identification of metabolic vulnerabilities in hypoxic tumours to improve patient outcomes
Status	Finished
Effective start/end date	1/10/18 → 30/09/22

Funding

Cancer Research UK

4 Article

A Mathematical Exploration of SDH-b Loss in Chromaffin Cells
Vera-Sigüenza, E., Rana, H., Nashebi, R., Cloete, I., Kl’uvčková, K., Spill, F. & Tennant, D. A., Apr 2025, In: Bulletin of Mathematical Biology. 87, 4, 36 p., 53.
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Mathematical reconstruction of the metabolic network in an in-vitro multiple myeloma model
Vera-Siguenza, E., Escribano Gonzalez, C., Serrano-Gonzalo, I., Eskla, K.-L., Spill, F. & Tennant, D., 15 Sept 2023, In: PLoS Computational Biology. 19, 9, 26 p., e1011374.
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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
Westbrook, R., Bridges, E., Roberts, J., Escribano Gonzalez, C., Eales, K., Vettore, L., Walker, P., Vera-Siguenza, E., Rana, H., Cuozzo, F., Eskla, K.-L., Vellama, H., Shaaban, A., Nixon, C., Luuk, H., Lavery, G., Hodson, D., Harris, A. L. & Tennant, D., 1 Feb 2022, In: Cell Reports. 38, 5, 15 p., 110320.
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