Pre-Receptor Regulation of Dehydroepiandrosterone Synthesis, Metabolism and Action

Research output

Research output per year 2004 2004 2006 2007 2009 2015 2016 2017

• 49 Article
• 10 Review article
• 1 Paper
• 1 Abstract
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2017

  11-oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome

  O'reilly, M., Kempegowda, P., Jenkinson, C., Taylor, A., Quanson, J. L., Storbeck, K.-H. & Arlt, W., Mar 2017, In: The Journal of clinical endocrinology and metabolism. 102, 3, p. 840-848

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Blood Level 100%
  • Insulin Resistance 100%
  • Androgen Blood Level 100%
  • Androgens 100%
  • Polycystic Ovary Syndrome 100%
  105 Citations (Scopus)

  335 Downloads (Pure)

• Bilateral testicular tumors resulting in recurrent Cushing's syndrome after bilateral adrenalectomy

  Puar, T., Engels, M., van Herwaarden, A., Sweep, F., Hulsbergen-van de Kaa, C., Kamphuis-van Ulzen, K., Chortis, V., Arlt, W., Stikkelbroeck, N., Claahsen-van der Grinten, H. & Hermus, A., Feb 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 2, p. 339-344

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cushing's Syndrome 100%
  • Bilateral Adrenalectomy 100%
  • Bilateral Testicular Cancer 100%
  • Cushing Syndrome 100%
  • Testis Tumor 100%
  11 Citations (Scopus)

  338 Downloads (Pure)

• Congenital Adrenal Hyperplasia: The Lancet Seminar Series

  El-Maouche, D., Arlt, W. & Merke, D. P., 30 May 2017, (E-pub ahead of print) In: The Lancet.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lancet 100%
  • Seminar Series 100%
  • Congenital Adrenal Hyperplasia 100%
  • Glucocorticoid 75%
  • Sex Hormone 50%
  168 Citations (Scopus)

  2491 Downloads (Pure)

• Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality

  Bancos, I., Hazeldine, J., Chortis, V., Hampson, P., Taylor, A. E., Lord, J. & Arlt, W., 1 Apr 2017, In: European Journal of Endocrinology. 176, 4, p. 471-480 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Increased Mortality 100%
  • Natural Killer Cell Activity 100%
  • Primary Adrenal Insufficiency 100%
  • Cell Function 100%
  • Natural Killer Cell 100%
  42 Citations (Scopus)

  234 Downloads (Pure)
• 2016

  A new dawn for androgens: novel lessons from 11-oxygenated C19 steroids

  Pretorius, E., Arlt, W. & Storbeck, K.-H., 9 Aug 2016, (E-pub ahead of print) In: Molecular and Cellular Endocrinology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Androgens 100%
  • 11-Oxygenated Steroids 100%
  • Precursor 100%
  • Metabolic Pathway 100%
  • Androgen Receptor 100%
  68 Citations (Scopus)

  1205 Downloads (Pure)

• Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women with Polycystic Ovary Syndrome

  Arlt, W., Torchen, L., Idkowiak, J., Fogel, N., O'Neil, D., Shackleton, C. & Dunaif, A., May 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 5, p. 2069-2075 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oxidoreductase 100%
  • Reductase 100%
  • Early childhood 100%
  • Reductase Activity 100%
  • Polycystic Ovary Syndrome 100%
  30 Citations (Scopus)

  176 Downloads (Pure)

• Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia

  Jones, C., Mallappa, A., Reisch, N., Nikolaou, N., Krone, N., Hughes, B., O'Neil, D., Whitaker, M. J., Tomlinson, J., Storbeck, K.-H., Merke, D. P., Ross, R. & Arlt, W., 15 Nov 2016, In: Journal of Clinical Endocrinology and Metabolism. 102, 6, p. 1797-1806

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Androgens 100%
  • Congenital Adrenal Hyperplasia 100%
  • Modified Release 100%
  • Glucocorticoid 100%
  • Androgen 100%
  29 Citations (Scopus)

  229 Downloads (Pure)

• Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone

  Debono, M., Harrison, R. F., Whitaker, M. J., Eckland, D., Arlt, W., Keevil, B. G. & Ross, R. J., Apr 2016, In: The Journal of clinical endocrinology and metabolism. 101, 4, p. 1469-1477 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cortisol 100%
  • Physiological Condition 100%
  • Serum Cortisol 100%
  • Hydrocortisone 100%
  • Salivary Cortisone 100%
  49 Citations (Scopus)

• Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase

  Chan, K. X., Mabbitt, P., Phua, S. Y., Mueller, J. W., Nisar, N., Gigolashvilli, T., Stroeher, E., Grassl, J., Arlt, W., Estavillo, G., Jackson, C. & Pogson, B., 2 Aug 2016, In: National Academy of Sciences. Proceedings. 113, 31, p. E4567-E4576 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phosphatase 100%
  • Oxidative Stress 100%
  • Chloroplast 100%
  • SAL1 100%
  • Arabidopsis thaliana 40%
  79 Citations (Scopus)

  621 Downloads (Pure)

• Steroid sulfatase sulfatase deficiency and androgen activation before and after puberty

  Idkowiak, J., Taylor, A. E., Subtil, S., O'neil, D. M., Vijzelaar, R., Dias, R. P., Amin, R., Barrett, T. G., Shackleton, C. H. L., Kirk, J. M. W., Moss, C. & Arlt, W., 2 Jun 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 6, p. 2545-53 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Steroid Sulfatase 100%
  • Androgens 100%
  • Puberty 100%
  • Sulfatase 100%
  • Androgen 100%
  19 Citations (Scopus)

  231 Downloads (Pure)
• 2015

  Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol

  Woods, C. P., Argese, N., Chapman, M., Boot, C., Webster, R., Dabhi, V., Grossman, A. B., Toogood, A. A., Arlt, W., Stewart, P. M., Crowley, R. K. & Tomlinson, J. W., Nov 2015, In: European Journal of Endocrinology. 173, 5, p. 633-42 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Salivary Cortisol 100%
  • Adrenal Suppression 100%
  • Inhaled Glucocorticoids 100%
  • Synacthen Stimulation Test 100%
  • Hydrocortisone 100%
  71 Citations (Scopus)

• Characterization of the molecular genetic pathology in patients with 11β-hydroxylase deficiency

  Mooij, C. F., Parajes, S., Rose, I. T., Taylor, A. E., Bayraktaroglu, T., Wass, J. A. H., Connell, J. M. C., Ray, D. W., Arlt, W. & Krone, N., Nov 2015, In: Clinical Endocrinology. 83, 5, p. 629-635 7 p.

  Research output: Contribution to journal › Article › peer-review

  • CYP11B1 100%
  • 11β-hydroxylase Deficiency 100%
  • Molecular Genetic Pathology 100%
  • Steroid 11beta Monooxygenase 100%
  • Molecular Genetics 100%
  8 Citations (Scopus)

• Effect of insulin on AKR1C3 expression in female adipose tissue: in-vivo and in-vitro study of adipose androgen generation in polycystic ovary syndrome

  O'Reilly, M., Gathercole, L., Capper, F., Arlt, W. & Tomlinson, J., 26 Feb 2015, In: The Lancet. 385 , Suppl 1, p. S16 1 p.

  Research output: Contribution to journal › Abstract › peer-review

  • In Vitro Study 100%
  • Adipose Tissue 100%
  • Androgens 100%
  • Insulin 100%
  • AKR1C3 100%

• PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation—in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations

  Oostdijk, W., Idkowiak, J., Mueller, J. W., House, P. J., Taylor, A. E., O'reilly, M. W., Hughes, B. A., De Vries, M. C., Kant, S. G., Santen, G. W. E., Verkerk, A. J. M. H., Uitterlinden, A. G., Wit, J. M., Losekoot, M. & Arlt, W., 1 Apr 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 4, p. E672-E680

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dehydroepiandrosterone 100%
  • Androgen Excess 100%
  • PAPSS2 100%
  • Androgen 100%
  • Prasterone 100%
  41 Citations (Scopus)

  171 Downloads (Pure)

• Role of ALADIN in human adrenocortical cells for oxidative stress response and steroidogenesis

  Jühlen, R., Idkowiak, J., Taylor, A. E., Kind, B., Arlt, W., Huebner, A. & Koehler, K., 13 Apr 2015, In: PLoS ONE. 10, 4, e0124582.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidative Stress 100%
  • Steroid Biosynthesis 100%
  • Steroidogenesis 100%
  • Oxidative Stress Response 100%
  • ALADIN 100%
  26 Citations (Scopus)

• Society for Endocrinology UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development (Revised 2015)

  Ahmed, S. F., Achermann, J. C., Arlt, W., Balen, A., Conway, G., Edwards, Z., Elford, S., Hughes, I. A., Izatt, L., Krone, N., Miles, H., O'Toole, S., Perry, L., Sanders, C., Simmonds, M., Watt, A. & Willis, D., 13 Aug 2015, In: Clinical Endocrinology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endocrinology 100%
  • Adolescence 100%
  • Disorders of Sex Development 100%
  • Clinician 50%
  • Pathophysiology 16%
  99 Citations (Scopus)

• The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer

  Shaw, G. L., Whitaker, H., Corcoran, M., Dunning, M. J., Luxton, H., Kay, J., Massie, C. E., Miller, J. L., Lamb, A. D., Ross-Adams, H., Russell, R., Nelson, A. W., Eldridge, M. D., Lynch, A. G., Ramos-Montoya, A., Mills, I. G., Taylor, A. E., Arlt, W., Shah, N. & Warren, A. Y. & 1 others, Neal, D. E., 10 Nov 2015, (E-pub ahead of print) In: European urology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prostate Cancer 100%
  • Early Effect 100%
  • Androgen Deprivation Therapy 100%
  • Androgen Receptor 100%
  • Androgen 100%
  33 Citations (Scopus)

• The Regulation of Steroid Action by Sulfation and Desulfation

  Mueller, J. W., Gilligan, L. C., Idkowiak, J., Arlt, W. & Foster, P. A., Oct 2015, In: Endocrine Reviews. 36, 5, p. 526-563 38 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sulfation 100%
  • Desulfation 100%
  • Polypeptide 100%
  • Sulfatase 100%
  • Organic Anion Transporter 50%
  185 Citations (Scopus)

  321 Downloads (Pure)
• 2014

  Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome : the utility of serum androstenedione

  O'Reilly, M., Taylor, A. E., Crabtree, N. J., Hughes, B. A., Capper, F., Crowley, R. K., Stewart, P. M., Tomlinson, J. W. & Arlt, W., 1 Mar 2014, In: The Journal of clinical endocrinology and metabolism. 99, 3, p. 1027–1036

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Androstenedione 100%
  • Polycystic Ovary Syndrome 100%
  • Metabolic Phenotype 100%
  • Hyperandrogenemia 100%
  • Androstenedione Blood Level 100%
  154 Citations (Scopus)

  423 Downloads (Pure)
• 2013

  Dehydroepiandrosterone exerts anti-glucocorticoid action on human preadipocyte proliferation, differentiation and glucose uptake

  Mcnelis, J. C., Manolopoulos, K. N., Gathercole, L. L., Bujalska, I. J., Stewart, P. M., Tomlinson, J. W. & Arlt, W., 1 Nov 2013, In: American Journal of Physiology: Endocrinology and Metabolism. 305, p. E1134-E1144

  Research output: Contribution to journal › Article › peer-review

  • Dehydroepiandrosterone 100%
  • Preadipocyte Proliferation 100%
  • Preadipocytes 100%
  • Glucose Uptake 100%
  • Antiglucocorticoid 100%
  33 Citations (Scopus)
• 2010

  Adrenal crisis in treated Addison's disease: a predictable but under-managed event

  White, K. & Arlt, W., 1 Jan 2010, In: European Journal of Endocrinology. 162, 1, p. 115-120 6 p.

  Research output: Contribution to journal › Article

  • Addison's Disease 100%
  • Adrenal Crisis 100%
  • Addison Disease 100%
  • Adrenal Cortex Insufficiency 100%
  • Demographic Characteristic 100%
  100 Citations (Scopus)

• A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (ChronocortTM) vs. conventional hydrocortisone (CortefTM) in the treatment of congenital adrenal hyperplasia

  Verma, S., VanRyzin, C., Sinaii, N., Kim, M., Nieman, L., Ravindran, S., Calis, K., Arlt, W., Ross, R. & Merke, D., 1 Apr 2010, In: Clinical Endocrinology. 72, 4, p. 441-447 7 p.

  Research output: Contribution to journal › Article

  • Pharmacokinetic Study 100%
  • Pharmacodynamic Study 100%
  • Hydrocortisone 100%
  • Congenital Adrenal Hyperplasia 100%
  • Delayed Release 100%
  87 Citations (Scopus)

• Dehdyroepiandrosterone Sulfate Directly Activates Protein Kinase C-beta to Increase Human Neutrophil Superoxide Generation

  Radford, D., Wang, K.-Q., McNelis, J., Taylor, A., Hechenberger, G., Hofmann, J., Chahal, H., Arlt, W. & Lord, J., 1 Apr 2010, In: Molecular Endocrinology. 24, 4, p. 813-821 9 p.

  Research output: Contribution to journal › Article

  • Superoxide Production 100%
  • Protein Kinase 100%
  • Human Neutrophils 100%
  • Dehydroepiandrosterone Sulfate (DHEAS) 100%
  • Superoxide 100%
  46 Citations (Scopus)
• 2009

  Fine tuning for quality of life: 21st century approach to treatment of Addison's disease.

  Reisch, N. & Arlt, W., 1 Jun 2009, In: Endocrinology and Metabolism Clinics of North America. 38, 2, p. 407-18, ix-x

  Research output: Contribution to journal › Review article

  • Quality of Life 100%
  • 21st Century 100%
  • Hydrocortisone 100%
  • Addison's Disease 100%
  • Adrenal Insufficiency 100%
  24 Citations (Scopus)

• Functional characterization of three CYP21A2 sequence variants (p.A265V, p.W302S, p.D322G) employing a yeast co-expression system.

  Bleicken, C., Loidi, L., Dhir, V., Parajes, S., Quinteiro, C., Dominguez, F., Grötzinger, J., Sippell, W., Riepe, F., Arlt, W. & Krone, N., 1 Feb 2009, In: Human Mutation. 30, 2, p. E443-50

  Research output: Contribution to journal › Article

  • Sequence Variants 100%
  • Functional Characterization 100%
  • Expression System 100%
  • CYP21A2 100%
  • Gene Expression System 100%
  15 Citations (Scopus)

• Genetics of congenital adrenal hyperplasia

  Krone, N. & Arlt, W., 1 Apr 2009, In: Best practice & research. Clinical endocrinology & metabolism. 23, 2, p. 181-92 12 p.

  Research output: Contribution to journal › Review article

  • Congenital Adrenal Hyperplasia 100%
  • Genetics 100%
  • Cytochrome P450 Reductase 100%
  • Enzyme 66%
  • Oxygenase 66%
  165 Citations (Scopus)

• Inactivating PAPSS2 Mutations in a Patient with Premature Pubarche

  Noordam, C., Dhir, V., McNelis, J., Schlereth, F., Hanley, N., Krone, N., Smeitink, J., Smeets, R., Sweep, F., Claahsen-van der Grinten, H. & Arlt, W., 1 May 2009, In: New England Journal of Medicine. 360, 22, p. 2310-2318 9 p.

  Research output: Contribution to journal › Article

  • Dehydroepiandrosterone 100%
  • PAPS Synthase 100%
  • SULT2A1 100%
  • Premature Pubarche 100%
  • Precocious Puberty 100%
  104 Citations (Scopus)

• Increased 5 alpha-Reductase Activity and Adrenocortical Drive in Women with Polycystic Ovary Syndrome

  Vassiliadi, D., Barber, T., Hughes, B., McCarthy, M., Wass, J., Franks, S., Nightingale, P., Tomlinson, J., Arlt, W. & Stewart, P., 1 Sept 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 9, p. 3558-3566 9 p.

  Research output: Contribution to journal › Article

  • Reductase Activity 100%
  • Polycystic Ovary Syndrome 100%
  • 5α-reductase 100%
  • Adrenocortical 100%
  • Metabolite 100%
  72 Citations (Scopus)

• Modified-release hydrocortisone to provide circadian cortisol profiles.

  Debono, M., Ghobadi, C., Rostami-Hodjegan, A., Huatan, H., Campbell, M., Newell-Price, J., Darzy, K., Merke, D., Arlt, W. & Ross, R., 17 Feb 2009, In: Journal of Clinical Endocrinology and Metabolism.

  Research output: Contribution to journal › Article

  • Dual-release Hydrocortisone 100%
  • Circadian Cortisol 100%
  • Hydrocortisone 100%
  • Modified Release 100%
  • Cortisol 66%
  189 Citations (Scopus)

• Nomenclature for alleles of the cytochrome P450 oxidoreductase gene.

  Sim, S., Miller, W., Zhong, X., Arlt, W., Ogata, T., Ding, X., Roland Wolf, C., Flück, C., Pandey, A., Henderson, C., Porter, T., Daly, A., Nebert, D. & Ingelman-Sundberg, M., 1 Jul 2009, In: Pharmacogenetics and Genomics. 19, 7, p. 565-566 2 p.

  Research output: Contribution to journal › Article
  27 Citations (Scopus)

• Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency

  Metherell, L., Naville, D., Halaby, G., Begeot, M., Huebner, A., Nürnberg, G., Nürnberg, P., Green, J., Tomlinson, J., Krone, N., Lin, L., Racine, M., Berney, D., Achermann, J., Arlt, W. & Clark, A., 22 Sept 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 10, p. 3865-71 7 p.

  Research output: Contribution to journal › Article

  Open Access

  • Non-classic 100%
  • Lipoid Congenital Adrenal Hyperplasia 100%
  • Masquerade 100%
  • Familial Glucocorticoid Deficiency 100%
  • Glucocorticoid 100%
  99 Citations (Scopus)

• Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene

  Dhir, V., Reisch, N., Bleicken, C., Lebl, J., Kamrath, C., Schwarz, H., Grötzinger, J., Sippell, W., Riepe, F., Arlt, W. & Krone, N., 1 Aug 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 8, p. 3058-64 7 p.

  Research output: Contribution to journal › Article

  • Functional Characterization 100%
  • CYP17A1 100%
  • Hydroxylase Deficiency 100%
  • CYP17A1 Gene 100%
  • Oxygenase 100%
  34 Citations (Scopus)

• The adrenal cortex and sexual differentiation during early human development

  Asby, D., Arlt, W. & Hanley, N., 1 Mar 2009, In: Reviews in endocrine & metabolic disorders. 10, 1, p. 43-49 7 p.

  Research output: Contribution to journal › Article

  • Androgens 100%
  • Adrenal Cortex 100%
  • Sex Differentiation 100%
  • Female Development 100%
  • Early Human Development 100%
  9 Citations (Scopus)

• The Approach to the Adult with Newly Diagnosed Adrenal Insufficiency

  Arlt, W., 1 Apr 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 4, p. 1059-1067 9 p.

  Research output: Contribution to journal › Article

  • Newly Diagnosed 100%
  • Adrenal Insufficiency 100%
  • Primary Adrenal Insufficiency 100%
  • Hydrocortisone 66%
  • Secondary Adrenal Insufficiency 66%
  109 Citations (Scopus)
• 2008

  Adrenal crisis causing critical illness related reversible myocardial dysfunction

  Sherlock, M., Gittoes, N. & Arlt, W., 1 Apr 2008, In: Clinical Endocrinology. 68, 4, p. 667-669 3 p.

  Research output: Contribution to journal › Article
  7 Citations (Scopus)

• Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine

  Marik, P., Pastores, S., Annane, D., Meduri, G., Sprung, C., Arlt, W., Keh, D., Briegel, J., Beishuizen, A., Dimopoulou, I., Tsagarakis, S., Singer, M., Chrousos, G., Zaloga, G., Bokhari, F. & Vogeser, M., 1 Jun 2008, In: Critical care medicine. 36, 6, p. 1937-1949 13 p.

  Research output: Contribution to journal › Review article

  • Consensus Statement 100%
  • American Colleges 100%
  • Corticosteroid Insufficiency 100%
  • Critically Ill Adult Patients 100%
  • Critical Care Medicine 100%
  642 Citations (Scopus)

• Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

  Lavery, G., Walker, E., Tiganescu, A., Ride, J., Shackleton, C., Tomlinson, J., Connell, J., Ray, D., Biason-Lauber, A., Malunowicz, E., Arlt, W. & Stewart, P., 15 Jul 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 3827-3832 6 p.

  Research output: Contribution to journal › Article

  • Reductase 100%
  • Cortisone 100%
  • Genetic Studies 100%
  • Inactivating mutation 100%
  • Glucose-6-phosphate Dehydrogenase (G6PD) 100%
  63 Citations (Scopus)

• Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature

  Meduri, G., Marik, P., Chrousos, G., Pastores, S., Arlt, W., Beishuizen, A., Bokhari, F., Zaloga, G. & Armane, D., 1 Jan 2008, In: Intensive Care Medicine. 34, 1, p. 61-69 9 p.

  Research output: Contribution to journal › Editorial

  • Relative Risk 100%
  • Glucocorticoid Therapy 100%
  • Steroid Treatment 100%
  • I(2) 100%
  • ARDS Network 100%
  134 Citations (Scopus)
• 2007

  Adult consequences of congenital adrenal hyperplasia

  Arlt, W. & Krone, N., 10 Dec 2007, In: Clinical Endocrinology. 68 Suppl 5, p. 158-64 7 p.

  Research output: Contribution to journal › Article

  • Congenital Adrenal Hyperplasia 100%
  • Glucocorticoid Replacement 33%
  • Adult Congenital Heart Disease 33%
  • Glucocorticoid 33%
  • Multidisciplinary Team 16%
  41 Citations (Scopus)

• Age-specific changes in sex steroid biosynthesis and sex development

  Krone, N., Hanley, N. & Arlt, W., 1 Sept 2007, In: Best practice & research. Clinical endocrinology & metabolism. 21, 3, p. 393-401 9 p.

  Research output: Contribution to journal › Article

  • Sex Steroids 100%
  • Age-specific 100%
  • Congenital Adrenal Hyperplasia 100%
  • Sexual Development 100%
  • Steroid Biosynthesis 100%
  26 Citations (Scopus)

• Androgen replacement in women

  Arlt, W., 1 Sept 2007, In: Annales d'endocrinologie. 68, 4, p. 251-7 7 p.

  Research output: Contribution to journal › Article
  1 Citation (Scopus)

• Congenital adrenal hyperplasia and P450 oxidoreductase deficiency

  Krone, N., Dhir, V., Ivison, H. & Arlt, W., 1 Feb 2007, In: Clinical Endocrinology. 66, 2, p. 162-72 11 p.

  Research output: Contribution to journal › Article

  • Congenital Adrenal Hyperplasia 100%
  • P450 Oxidoreductase Deficiency 100%
  • Cytochrome P450 Reductase 100%
  • Steroid Biosynthesis 100%
  • Steroidogenesis 80%
  80 Citations (Scopus)

• DHEA: why, when, and how much - DHEA replacement in adrenal insufficiency

  Allolio, B., Arlt, W. & Hahner, S., 1 Sept 2007, p. 268-273. 6 p.

  Research output: Contribution to conference (unpublished) › Paper
  19 Citations (Scopus)

• Differential Inhibition of CYP17A1 and CYP21A2 Activities by the P450 Oxidoreductase Mutant A287P

  Dhir, V., Ivison, H., Krone, N., Shackleton, C., Doherty, A., Stewart, P. & Arlt, W., 24 Apr 2007, In: Molecular Endocrinology. 21, 8, p. 1958-68 11 p.

  Research output: Contribution to journal › Article

  • Differential Inhibition 100%
  • Cytochrome P450 Reductase 100%
  • CYP21A2 100%
  • CYP17A1 100%
  • Cytochrome P450 Enzymes 30%
  58 Citations (Scopus)

• Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis

  Hahner, S., Loeffler, M., Fassnacht, M., Weismann, D., Koschker, A., Quinkler, M., Decker, O., Arlt, W. & Allolio, B., 1 Oct 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 10, p. 3912-3922 11 p.

  Research output: Contribution to journal › Article

  • Sectional Analysis 100%
  • Adrenal Insufficiency 100%
  • Subjective Health Status 100%
  • Cross Sectional Study 100%
  • Health Status 100%
  193 Citations (Scopus)

• P450 oxidoreductase deficiency and Antley-Bixler syndrome

  Arlt, W., 1 Dec 2007, In: Reviews in endocrine & metabolic disorders. 8, 4, p. 301-7 7 p.

  Research output: Contribution to journal › Article

  • Cytochrome P450 Reductase 100%
  • Antley-Bixler Syndrome 100%
  • P450 Oxidoreductase Deficiency 100%
  • External Genitalia 50%
  • Skeletal Malformations 50%
  20 Citations (Scopus)
• 2006

  Androgen therapy in women

  Arlt, W., 1 Jan 2006, In: European Journal of Endocrinology. 154, p. 1-11 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Androgen Deficiency 100%
  • Androgen Therapy 100%
  • Androgen 100%
  • Dehydroepiandrosterone 50%
  • Menopause 50%
  89 Citations (Scopus)

• Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock

  Arlt, W., Hammer, F., Sanning, P., Butcher, S., Lord, J., Allolio, B., Annane, D. & Stewart, P., 18 Apr 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 7, p. 2548-2554 7 p.

  Research output: Contribution to journal › Article

  • Dissociation 100%
  • Dehydroepiandrosterone 100%
  • Septic Shock 100%
  • Dehydroepiandrosterone Sulfate (DHEAS) 100%
  • Prasterone 100%
  65 Citations (Scopus)

• Linking Antley–Bixler syndrome and congenital adrenal hyperplasia: A novel case of P450 oxidoreductase deficiency

  Williamson, L., Arlt, W., Shackleton, C., Kelley, R. & Braddock, S., 1 Sept 2006, In: American Journal of Medical Genetics Part A. 140A, 17, p. 1797-1803 7 p.

  Research output: Contribution to journal › Article

  • Congenital Adrenal Hyperplasia 100%
  • Antley-Bixler Syndrome 100%
  • P450 Oxidoreductase Deficiency 100%
  • Cytochrome P450 Reductase 100%
  • Autosomal Recessive Inheritance 66%
  16 Citations (Scopus)

• POR R457H is a global founder mutation causing Antley–Bixler syndrome with autosomal recessive trait

  Adachi, M., Asakura, Y., Matsuo, M., Yamamoto, T., Hanaki, K. & Arlt, W., 15 Mar 2006, In: American Journal of Medical Genetics Part A. 140, 6, p. 633-635 3 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)