Pre-Receptor Regulation of Dehydroepiandrosterone Synthesis, Metabolism and Action

Research output

Research output per year 2004 2004 2006 2007 2009 2015 2016 2017

• 49 Article
• 10 Review article
• 1 Paper
• 1 Abstract
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2017

  11-oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome

  O'reilly, M., Kempegowda, P., Jenkinson, C., Taylor, A., Quanson, J. L., Storbeck, K-H. & Arlt, W., Mar 2017, In: The Journal of clinical endocrinology and metabolism. 102, 3, p. 840-848

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • C19-Steroid 100%
  • Androgen 76%
  • Polycystic Ovary Syndrome 67%
  • Androgens 55%
  • Steroids 45%
  105 Citations (Scopus)

  295 Downloads (Pure)

• Bilateral testicular tumors resulting in recurrent Cushing's syndrome after bilateral adrenalectomy

  Puar, T., Engels, M., van Herwaarden, A., Sweep, F., Hulsbergen-van de Kaa, C., Kamphuis-van Ulzen, K., Chortis, V., Arlt, W., Stikkelbroeck, N., Claahsen-van der Grinten, H. & Hermus, A., Feb 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 2, p. 339-344

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cushing Syndrome 100%
  • Adrenalectomy 95%
  • Testicular Neoplasms 95%
  • Steroid 76%
  • Pituitary ACTH Hypersecretion 65%
  11 Citations (Scopus)

  293 Downloads (Pure)

• Congenital Adrenal Hyperplasia: The Lancet Seminar Series

  El-Maouche, D., Arlt, W. & Merke, D. P., 30 May 2017, (E-pub ahead of print) In: The Lancet.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Congenital Adrenal Hyperplasia 100%
  • Glucocorticoids 68%
  • Steroids 37%
  • Cosyntropin 36%
  • Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 35%
  168 Citations (Scopus)

  2178 Downloads (Pure)

• Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality

  Bancos, I., Hazeldine, J., Chortis, V., Hampson, P., Taylor, A. E., Lord, J. & Arlt, W., 1 Apr 2017, In: European Journal of Endocrinology. 176, 4, p. 471-480 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Addison Disease 100%
  • Natural Killer Cells 67%
  • Mortality 36%
  • Neutrophils 22%
  • Natural Killer Cell Receptors 20%
  42 Citations (Scopus)

  194 Downloads (Pure)
• 2016

  A new dawn for androgens: novel lessons from 11-oxygenated C19 steroids

  Pretorius, E., Arlt, W. & Storbeck, K-H., 9 Aug 2016, (E-pub ahead of print) In: Molecular and Cellular Endocrinology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • C19-Steroid 100%
  • Androgen 76%
  • Androgens 55%
  • 11-ketodihydrotestosterone 45%
  • Steroids 45%
  68 Citations (Scopus)

  1048 Downloads (Pure)

• Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women with Polycystic Ovary Syndrome

  Arlt, W., Torchen, L., Idkowiak, J., Fogel, N., O'Neil, D., Shackleton, C. & Dunaif, A., May 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 5, p. 2069-2075 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Androgen 100%
  • Polycystic Ovary Syndrome 88%
  • Nuclear Family 85%
  • Oxidoreductases 72%
  • Androgens 50%
  30 Citations (Scopus)

  152 Downloads (Pure)

• Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia

  Jones, C., Mallappa, A., Reisch, N., Nikolaou, N., Krone, N., Hughes, B., O'Neil, D., Whitaker, M. J., Tomlinson, J., Storbeck, K-H., Merke, D. P., Ross, R. & Arlt, W., 15 Nov 2016, In: Journal of Clinical Endocrinology and Metabolism. 102, 6, p. 1797-1806

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Congenital Adrenal Hyperplasia 100%
  • Glucocorticoid 97%
  • Androgen 94%
  • Androgens 69%
  • Glucocorticoids 68%
  29 Citations (Scopus)

  202 Downloads (Pure)

• Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone

  Debono, M., Harrison, R. F., Whitaker, M. J., Eckland, D., Arlt, W., Keevil, B. G. & Ross, R. J., Apr 2016, In: The Journal of clinical endocrinology and metabolism. 101, 4, p. 1469-1477 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cortisone 100%
  • Cortisol 90%
  • Hydrocortisone 62%
  • Serum 15%
  • cortisol binding globulin 10%
  49 Citations (Scopus)

• Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase

  Chan, K. X., Mabbitt, P., Phua, S. Y., Mueller, J. W., Nisar, N., Gigolashvilli, T., Stroeher, E., Grassl, J., Arlt, W., Estavillo, G., Jackson, C. & Pogson, B., 2 Aug 2016, In: National Academy of Sciences. Proceedings. 113, 31, p. E4567-E4576 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • inactivation 100%
  • chloroplasts 97%
  • oxidative stress 95%
  • Arabidopsis thaliana 47%
  • phosphates 42%
  79 Citations (Scopus)

  573 Downloads (Pure)

• Steroid sulfatase sulfatase deficiency and androgen activation before and after puberty

  Idkowiak, J., Taylor, A. E., Subtil, S., O'neil, D. M., Vijzelaar, R., Dias, R. P., Amin, R., Barrett, T. G., Shackleton, C. H. L., Kirk, J. M. W., Moss, C. & Arlt, W., 2 Jun 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 6, p. 2545-53 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Steryl-Sulfatase 100%
  • Sulfatases 92%
  • Androgen 80%
  • Puberty 67%
  • Steroid 58%
  19 Citations (Scopus)

  205 Downloads (Pure)
• 2015

  Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol

  Woods, C. P., Argese, N., Chapman, M., Boot, C., Webster, R., Dabhi, V., Grossman, A. B., Toogood, A. A., Arlt, W., Stewart, P. M., Crowley, R. K. & Tomlinson, J. W., Nov 2015, In: European Journal of Endocrinology. 173, 5, p. 633-42 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucocorticoids 100%
  • Hydrocortisone 97%
  • Hypothalamo-Hypophyseal System 25%
  • Adrenal Insufficiency 23%
  • Serum 16%
  71 Citations (Scopus)

• Characterization of the molecular genetic pathology in patients with 11β-hydroxylase deficiency

  Mooij, C. F., Parajes, S., Rose, I. T., Taylor, A. E., Bayraktaroglu, T., Wass, J. A. H., Connell, J. M. C., Ray, D. W., Arlt, W. & Krone, N., Nov 2015, In: Clinical Endocrinology. 83, 5, p. 629-635 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Steroid 11-beta-Hydroxylase 100%
  • Molecular Pathology 71%
  • Mixed Function Oxygenases 70%
  • Molecular Biology 50%
  • Mutation 30%
  8 Citations (Scopus)

• Effect of insulin on AKR1C3 expression in female adipose tissue: in-vivo and in-vitro study of adipose androgen generation in polycystic ovary syndrome

  O'Reilly, M., Gathercole, L., Capper, F., Arlt, W. & Tomlinson, J., 26 Feb 2015, In: The Lancet. 385 , Suppl 1, p. S16 1 p.

  Research output: Contribution to journal › Abstract › peer-review

  • Polycystic Ovary Syndrome 100%
  • Androgens 82%
  • Adipose Tissue 74%
  • Insulin 61%
  • Insulin Receptor 50%

• PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation—in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations

  Oostdijk, W., Idkowiak, J., Mueller, J. W., House, P. J., Taylor, A. E., O'reilly, M. W., Hughes, B. A., De Vries, M. C., Kant, S. G., Santen, G. W. E., Verkerk, A. J. M. H., Uitterlinden, A. G., Wit, J. M., Losekoot, M. & Arlt, W., 1 Apr 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 4, p. E672-E680

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dehydroepiandrosterone 100%
  • Androgen 89%
  • Androgens 64%
  • Mutation 59%
  • In Vitro Techniques 31%
  41 Citations (Scopus)

  150 Downloads (Pure)

• Role of ALADIN in human adrenocortical cells for oxidative stress response and steroidogenesis

  Jühlen, R., Idkowiak, J., Taylor, A. E., Kind, B., Arlt, W., Huebner, A. & Koehler, K., 13 Apr 2015, In: PLoS ONE. 10, 4, e0124582.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Achalasia Addisonianism Alacrimia syndrome 100%
  • steroidogenesis 65%
  • Cytochrome P450 60%
  • Oxidative Stress 56%
  • Cytochrome P-450 Enzyme System 55%
  26 Citations (Scopus)

• Society for Endocrinology UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development (Revised 2015)

  Ahmed, S. F., Achermann, J. C., Arlt, W., Balen, A., Conway, G., Edwards, Z., Elford, S., Hughes, I. A., Izatt, L., Krone, N., Miles, H., O'Toole, S., Perry, L., Sanders, C., Simmonds, M., Watt, A. & Willis, D., 13 Aug 2015, In: Clinical Endocrinology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Disorders of Sex Development 100%
  • Endocrinology 88%
  • Parents 22%
  • Endocrinologists 19%
  • Newborn Infant 11%
  99 Citations (Scopus)

• The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer

  Shaw, G. L., Whitaker, H., Corcoran, M., Dunning, M. J., Luxton, H., Kay, J., Massie, C. E., Miller, J. L., Lamb, A. D., Ross-Adams, H., Russell, R., Nelson, A. W., Eldridge, M. D., Lynch, A. G., Ramos-Montoya, A., Mills, I. G., Taylor, A. E., Arlt, W., Shah, N., Warren, A. Y., & 1 othersNeal, D. E., 10 Nov 2015, (E-pub ahead of print) In: European urology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Androgens 100%
  • Castration 96%
  • Prostatic Neoplasms 86%
  • Androgen Receptors 70%
  • Estrogen Receptor alpha 50%
  33 Citations (Scopus)

• The Regulation of Steroid Action by Sulfation and Desulfation

  Mueller, J. W., Gilligan, L. C., Idkowiak, J., Arlt, W. & Foster, P. A., Oct 2015, In: Endocrine Reviews. 36, 5, p. 526-563 38 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Steroids 100%
  • Anions 41%
  • X-Linked Ichthyosis 31%
  • Steryl-Sulfatase 29%
  • Sulfatases 27%
  185 Citations (Scopus)

  286 Downloads (Pure)
• 2014

  Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome : the utility of serum androstenedione

  O'Reilly, M., Taylor, A. E., Crabtree, N. J., Hughes, B. A., Capper, F., Crowley, R. K., Stewart, P. M., Tomlinson, J. W. & Arlt, W., 1 Mar 2014, In: The Journal of clinical endocrinology and metabolism. 99, 3, p. 1027–1036

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Androgen 100%
  • Androstenedione 96%
  • Polycystic Ovary Syndrome 88%
  • Androgens 72%
  • Metabolic 64%
  154 Citations (Scopus)

  397 Downloads (Pure)
• 2013

  Dehydroepiandrosterone exerts anti-glucocorticoid action on human preadipocyte proliferation, differentiation and glucose uptake

  Mcnelis, J. C., Manolopoulos, K. N., Gathercole, L. L., Bujalska, I. J., Stewart, P. M., Tomlinson, J. W. & Arlt, W., 1 Nov 2013, In: American Journal of Physiology: Endocrinology and Metabolism. 305, p. E1134-E1144

  Research output: Contribution to journal › Article › peer-review

  • Dehydroepiandrosterone 100%
  • Glucocorticoids 74%
  • 11-beta-Hydroxysteroid Dehydrogenases 59%
  • Glucose 51%
  • Adipocytes 45%
  33 Citations (Scopus)
• 2010

  Adrenal crisis in treated Addison's disease: a predictable but under-managed event

  White, K. & Arlt, W., 1 Jan 2010, In: European Journal of Endocrinology. 162, 1, p. 115-120 6 p.

  Research output: Contribution to journal › Article

  • Addison Disease 100%
  • Emergencies 16%
  • Endocrinologists 13%
  • Demography 13%
  • New Zealand 10%
  100 Citations (Scopus)

• A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (ChronocortTM) vs. conventional hydrocortisone (CortefTM) in the treatment of congenital adrenal hyperplasia

  Verma, S., VanRyzin, C., Sinaii, N., Kim, MS., Nieman, LK., Ravindran, S., Calis, KA., Arlt, W., Ross, RJ. & Merke, DP., 1 Apr 2010, In: Clinical Endocrinology. 72, 4, p. 441-447 7 p.

  Research output: Contribution to journal › Article

  • Congenital Adrenal Hyperplasia 100%
  • Hydrocortisone 67%
  • Pharmacokinetics 56%
  • Therapeutics 12%
  • Androstenedione 10%
  87 Citations (Scopus)

• Dehdyroepiandrosterone Sulfate Directly Activates Protein Kinase C-beta to Increase Human Neutrophil Superoxide Generation

  Radford, DJ., Wang, K-Q., McNelis, J., Taylor, A., Hechenberger, G., Hofmann, J., Chahal, H., Arlt, W. & Lord, J., 1 Apr 2010, In: Molecular Endocrinology. 24, 4, p. 813-821 9 p.

  Research output: Contribution to journal › Article

  • Protein Kinase C beta 100%
  • Dehydroepiandrosterone Sulfate 86%
  • Sulfates 74%
  • Superoxides 68%
  • Neutrophils 53%
  46 Citations (Scopus)
• 2009

  Fine tuning for quality of life: 21st century approach to treatment of Addison's disease.

  Reisch, N. & Arlt, W., 1 Jun 2009, In: Endocrinology and Metabolism Clinics of North America. 38, 2, p. 407-18, ix-x

  Research output: Contribution to journal › Review article

  • Addison Disease 100%
  • Hydrocortisone 64%
  • Mineralocorticoids 62%
  • Adrenal Insufficiency 62%
  • Quality of Life 47%
  24 Citations (Scopus)

• Functional characterization of three CYP21A2 sequence variants (p.A265V, p.W302S, p.D322G) employing a yeast co-expression system.

  Bleicken, C., Loidi, L., Dhir, V., Parajes, S., Quinteiro, C., Dominguez, F., Grötzinger, J., Sippell, WG., Riepe, FG., Arlt, W. & Krone, N., 1 Feb 2009, In: Human Mutation. 30, 2, p. E443-50

  Research output: Contribution to journal › Article

  • Congenital Adrenal Hyperplasia 100%
  • Yeasts 61%
  • Steroid 21-Hydroxylase 27%
  • Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 26%
  • In Vitro Techniques 24%
  15 Citations (Scopus)

• Genetics of congenital adrenal hyperplasia

  Krone, N. & Arlt, W., 1 Apr 2009, In: Best practice & research. Clinical endocrinology & metabolism. 23, 2, p. 181-92 12 p.

  Research output: Contribution to journal › Review article

  • Congenital Adrenal Hyperplasia 100%
  • Cytochrome P-450 Enzyme System 73%
  • Oxidoreductases 69%
  • Mixed Function Oxygenases 56%
  • 3b-Hydroxysteroid Dehydrogenase Deficiency 46%
  165 Citations (Scopus)

• Inactivating PAPSS2 Mutations in a Patient with Premature Pubarche

  Noordam, C., Dhir, V., McNelis, J., Schlereth, F., Hanley, NA., Krone, N., Smeitink, JA., Smeets, R., Sweep, FCGJ., Claahsen-van der Grinten, HL. & Arlt, W., 1 May 2009, In: New England Journal of Medicine. 360, 22, p. 2310-2318 9 p.

  Research output: Contribution to journal › Article

  • Androgens 100%
  • Phosphoadenosine Phosphosulfate 91%
  • Dehydroepiandrosterone 66%
  • Mutation 61%
  • dehydroepiandrosterone sulfotransferase 50%
  104 Citations (Scopus)

• Increased 5 alpha-Reductase Activity and Adrenocortical Drive in Women with Polycystic Ovary Syndrome

  Vassiliadi, D., Barber, TM., Hughes, B., McCarthy, MI., Wass, JAH., Franks, S., Nightingale, P., Tomlinson, J., Arlt, W. & Stewart, P., 1 Sept 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 9, p. 3558-3566 9 p.

  Research output: Contribution to journal › Article

  • Cholestenone 5 alpha-Reductase 100%
  • Polycystic Ovary Syndrome 66%
  • Drive 61%
  • Cortisol 61%
  • Androgen 59%
  72 Citations (Scopus)

• Modified-release hydrocortisone to provide circadian cortisol profiles.

  Debono, M., Ghobadi, C., Rostami-Hodjegan, A., Huatan, H., Campbell, M., Newell-Price, J., Darzy, K., Merke, DP., Arlt, W. & Ross, RJ., 17 Feb 2009, In: Journal of Clinical Endocrinology and Metabolism.

  Research output: Contribution to journal › Article

  • Cortisol 100%
  • Hydrocortisone 69%
  • Glucocorticoid 16%
  • Healthy Volunteers 12%
  • Metabolic 10%
  189 Citations (Scopus)

• Nomenclature for alleles of the cytochrome P450 oxidoreductase gene.

  Sim, SC., Miller, WL., Zhong, XB., Arlt, W., Ogata, T., Ding, X., Roland Wolf, C., Flück, CE., Pandey, AV., Henderson, CJ., Porter, TD., Daly, AK., Nebert, DW. & Ingelman-Sundberg, M., 1 Jul 2009, In: Pharmacogenetics and Genomics. 19, 7, p. 565-566 2 p.

  Research output: Contribution to journal › Article
  27 Citations (Scopus)

• Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency

  Metherell, LA., Naville, D., Halaby, G., Begeot, M., Huebner, A., Nürnberg, G., Nürnberg, P., Green, J., Tomlinson, J., Krone, N., Lin, L., Racine, M., Berney, DM., Achermann, JC., Arlt, W. & Clark, AJ., 22 Sept 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 10, p. 3865-71 7 p.

  Research output: Contribution to journal › Article

  Open Access

  • Lipoid congenital adrenal hyperplasia 100%
  • Glucocorticoid 71%
  • Glucocorticoids 50%
  • Mutation 46%
  • Chromosomes, Human, Pair 8 25%
  99 Citations (Scopus)

• Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene

  Dhir, V., Reisch, N., Bleicken, CM., Lebl, J., Kamrath, C., Schwarz, HP., Grötzinger, J., Sippell, WG., Riepe, FG., Arlt, W. & Krone, N., 1 Aug 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 8, p. 3058-64 7 p.

  Research output: Contribution to journal › Article

  • Steroid Hydroxylases 100%
  • Steroid 55%
  • Steroid 17-alpha-Hydroxylase 52%
  • Mutation 51%
  • Mixed Function Oxygenases 40%
  34 Citations (Scopus)

• The adrenal cortex and sexual differentiation during early human development

  Asby, DJ., Arlt, W. & Hanley, NA., 1 Mar 2009, In: Reviews in endocrine & metabolic disorders. 10, 1, p. 43-49 7 p.

  Research output: Contribution to journal › Article

  • Sex Differentiation 100%
  • Adrenal Cortex 92%
  • Human Development 81%
  • Androgens 55%
  • Virilism 42%
  9 Citations (Scopus)

• The Approach to the Adult with Newly Diagnosed Adrenal Insufficiency

  Arlt, W., 1 Apr 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 4, p. 1059-1067 9 p.

  Research output: Contribution to journal › Article

  • Mineralocorticoid 100%
  • Dehydroepiandrosterone 89%
  • Addison Disease 86%
  • Glucocorticoid 81%
  • Adrenal Insufficiency 80%
  109 Citations (Scopus)
• 2008

  Adrenal crisis causing critical illness related reversible myocardial dysfunction

  Sherlock, M., Gittoes, N. & Arlt, W., 1 Apr 2008, In: Clinical Endocrinology. 68, 4, p. 667-669 3 p.

  Research output: Contribution to journal › Article
  7 Citations (Scopus)

• Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine

  Marik, PE., Pastores, SM., Annane, D., Meduri, GU., Sprung, CL., Arlt, W., Keh, D., Briegel, J., Beishuizen, A., Dimopoulou, I., Tsagarakis, S., Singer, M., Chrousos, GP., Zaloga, G., Bokhari, F. & Vogeser, M., 1 Jun 2008, In: Critical care medicine. 36, 6, p. 1937-1949 13 p.

  Research output: Contribution to journal › Review article

  • Advisory Committees 100%
  • Critical Illness 87%
  • Critical Care 82%
  • Adrenal Cortex Hormones 76%
  • Medicine 68%
  642 Citations (Scopus)

• Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

  Lavery, G., Walker, E., Tiganescu, A., Ride, J., Shackleton, C., Tomlinson, J., Connell, JM., Ray, DW., Biason-Lauber, A., Malunowicz, EM., Arlt, W. & Stewart, P., 15 Jul 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 3827-3832 6 p.

  Research output: Contribution to journal › Article

  • Cortisone reductase deficiency 100%
  • galactose-6-phosphate dehydrogenase 88%
  • Hexose 6-Phosphate 86%
  • Cortisone 68%
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 44%
  63 Citations (Scopus)

• Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature

  Meduri, GU., Marik, PE., Chrousos, GP., Pastores, SM., Arlt, W., Beishuizen, A., Bokhari, F., Zaloga, G. & Armane, D., 1 Jan 2008, In: Intensive Care Medicine. 34, 1, p. 61-69 9 p.

  Research output: Contribution to journal › Editorial

  • Steroids 100%
  • Glucocorticoids 73%
  • Acute Lung Injury 30%
  • Adult Respiratory Distress Syndrome 29%
  • Secondary Prevention 26%
  134 Citations (Scopus)
• 2007

  Adult consequences of congenital adrenal hyperplasia

  Arlt, W. & Krone, N., 10 Dec 2007, In: Clinical Endocrinology. 68 Suppl 5, p. 158-64 7 p.

  Research output: Contribution to journal › Article

  • Congenital Adrenal Hyperplasia 100%
  • Glucocorticoids 27%
  • Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 21%
  • Mineralocorticoids 19%
  • Genetic Counseling 16%
  41 Citations (Scopus)

• Age-specific changes in sex steroid biosynthesis and sex development

  Krone, N., Hanley, NA. & Arlt, W., 1 Sept 2007, In: Best practice & research. Clinical endocrinology & metabolism. 21, 3, p. 393-401 9 p.

  Research output: Contribution to journal › Article

  • Sexual Development 100%
  • Congenital Adrenal Hyperplasia 76%
  • Sex Differentiation 76%
  • Steroids 57%
  • Androgens 52%
  26 Citations (Scopus)

• Androgen replacement in women

  Arlt, W., 1 Sept 2007, In: Annales d'endocrinologie. 68, 4, p. 251-7 7 p.

  Research output: Contribution to journal › Article
  1 Citation (Scopus)

• Congenital adrenal hyperplasia and P450 oxidoreductase deficiency

  Krone, N., Dhir, V., Ivison, H. & Arlt, W., 1 Feb 2007, In: Clinical Endocrinology. 66, 2, p. 162-72 11 p.

  Research output: Contribution to journal › Article

  • Congenital Adrenal Hyperplasia 100%
  • Oxidoreductases 69%
  • Mixed Function Oxygenases 63%
  • 3(17)-hydroxysteroid dehydrogenase 35%
  • Androgens 34%
  80 Citations (Scopus)

• DHEA: why, when, and how much - DHEA replacement in adrenal insufficiency

  Allolio, B., Arlt, W. & Hahner, S., 1 Sept 2007, p. 268-273. 6 p.

  Research output: Contribution to conference (unpublished) › Paper
  19 Citations (Scopus)

• Differential Inhibition of CYP17A1 and CYP21A2 Activities by the P450 Oxidoreductase Mutant A287P

  Dhir, V., Ivison, H., Krone, N., Shackleton, C., Doherty, AJ., Stewart, P. & Arlt, W., 24 Apr 2007, In: Molecular Endocrinology. 21, 8, p. 1958-68 11 p.

  Research output: Contribution to journal › Article

  • Oxidoreductases 100%
  • Cytochrome P-450 Enzyme System 63%
  • Electrons 26%
  • Mutation 18%
  • Flavin Mononucleotide 16%
  58 Citations (Scopus)

• Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis

  Hahner, S., Loeffler, M., Fassnacht, M., Weismann, D., Koschker, AC., Quinkler, M., Decker, O., Arlt, W. & Allolio, B., 1 Oct 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 10, p. 3912-3922 11 p.

  Research output: Contribution to journal › Article

  • Glucocorticoid 100%
  • Adrenal Insufficiency 98%
  • Diagnostic Self Evaluation 93%
  • Health Status 67%
  • Dimension 58%
  193 Citations (Scopus)

• P450 oxidoreductase deficiency and Antley-Bixler syndrome

  Arlt, W., 1 Dec 2007, In: Reviews in endocrine & metabolic disorders. 8, 4, p. 301-7 7 p.

  Research output: Contribution to journal › Article

  • Antley-Bixler Syndrome Phenotype 100%
  • Oxidoreductases 49%
  • Electrons 21%
  • Mutation 20%
  • Cytochrome P-450 Enzyme System 17%
  20 Citations (Scopus)
• 2006

  Androgen therapy in women

  Arlt, W., 1 Jan 2006, In: European Journal of Endocrinology. 154, p. 1-11 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Androgens 100%
  • Libido 26%
  • Dehydroepiandrosterone 24%
  • Menopause 20%
  • Therapeutics 17%
  89 Citations (Scopus)

• Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock

  Arlt, W., Hammer, F., Sanning, P., Butcher, SK., Lord, J., Allolio, B., Annane, D. & Stewart, P., 18 Apr 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 7, p. 2548-2554 7 p.

  Research output: Contribution to journal › Article

  • Dehydroepiandrosterone Sulfate 100%
  • Dehydroepiandrosterone 86%
  • Septic Shock 63%
  • Dissociation 43%
  • Cortisol 42%
  65 Citations (Scopus)

• Linking Antley–Bixler syndrome and congenital adrenal hyperplasia: A novel case of P450 oxidoreductase deficiency

  Williamson, L., Arlt, W., Shackleton, C., Kelley, RI. & Braddock, SR., 1 Sept 2006, In: American Journal of Medical Genetics Part A. 140A, 17, p. 1797-1803 7 p.

  Research output: Contribution to journal › Article

  • Antley-Bixler Syndrome Phenotype 100%
  • Congenital Adrenal Hyperplasia 71%
  • Oxidoreductases 49%
  • Urogenital Abnormalities 28%
  • Choanal Atresia 27%
  16 Citations (Scopus)

• POR R457H is a global founder mutation causing Antley–Bixler syndrome with autosomal recessive trait

  Adachi, M., Asakura, Y., Matsuo, M., Yamamoto, T., Hanaki, K. & Arlt, W., 15 Mar 2006, In: American Journal of Medical Genetics Part A. 140, 6, p. 633-635 3 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)