OPTIMising therapies, discovering therapeutic targets and AI assisted clinical management for patients Living with complex multimorbidity (OPTIMAL study)

Gkoutos, Georgios (Co-Investigator)
Sapey, Elizabeth (Co-Investigator)
Nirantharakumar, Krishnarajah (Co-Investigator)
Tino, Peter (Co-Investigator)
Jackson, Louise (Co-Investigator)
Lord, Janet (Co-Investigator)
Little, Max (Co-Investigator)
Marshall, Tom (Co-Investigator)
Gokhale, Krishna (Co-Investigator)
Greenfield, Sheila (Co-Investigator)
Haroon, Shamil (Co-Investigator)
Crowe, Francesca (Co-Investigator)
Jackson, Thomas (Principal Investigator)
Karwath, Andreas (Researcher)

Short title	OPTIMising therapies, discovering therapeutic targets and AI assisted clinical management for patients Living with complex multimorbidity (OPTIMAL study)
Status	Finished
Effective start/end date	1/08/21 → 31/10/25

Funding

NIHR

Exploring Patient Perspectives on the Use of Artificial Intelligence to Inform Joint Decision-Making for Patients With Multiple Conditions in Primary Care in the United Kingdom: Qualitative Study
Flanagan, S., Spurway, C., Jackson, L., Cooper, J., Crowe, F. L., Haroon, S., Marshall, T., Fitzsimmons, L., Hathaway, E., Nirantharakumar, K., Jackson, T. & Greenfield, S., 21 Apr 2026, In: Journal of Medical Internet Research. 28, 12 p., e87507.
Research output: Contribution to journal › Article › peer-review

Open Access
File
7 Downloads (Pure)
SurvivEHR: a competing risks, time-to-event foundation model for multiple long-term conditions from primary care electronic health records
Gadd, C., Gokhale, K., Acharya, A., Cooper, J., Crowe, F., Fitzsimmons, L., Jackson, T., Nirantharakumar, K., Yau, C. & OPTIMAL Consortium, 9 May 2026, (E-pub ahead of print) In: npj Digital Medicine.
Research output: Contribution to journal › Article › peer-review

Open Access
File
12 Downloads (Pure)
Defining phenotypes of disease severity for long-term cardiovascular, renal, metabolic, and mental health conditions in primary care electronic health records: A mixed-methods study using the nominal group technique
Cooper, J., Jackson, T., Haroon, S., Crowe, F., Hathaway, E., Fitzsimmons, L. & Nirantharakumar, K., Jun 2025, In: Journal of Biomedical Informatics. 166, 12 p., 104831.
Research output: Contribution to journal › Article › peer-review

Open Access
File
95 Downloads (Pure)