NMR Studies of Membrane Associated Proteins

Research output

Research output per year 2005 2006 2016

• 19 Article

Research output per year

Research output per year

Search results

• 2016

  Secondary structure and 1H, 13C and 15N resonance assignments of Skint-1: a selecting ligand for a murine γδ T cell subset implicated in tumour suppression

  Salim, M., Willcox, C. R., Mohammed, F., Hayday, A. C., Overduin, M., Willcox, B. E. & Knowles, T. J., Oct 2016, In: Biomolecular NMR Assignments. 10, 2, p. 357–360

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epidermal Cells 100%
  • T-Lymphocyte Subsets 91%
  • Dendritic Cells 76%
  • Secondary Structure 75%
  • Chemical Shift 68%
  150 Downloads (Pure)
• 2014

  Structural insights into the activation of the RhoA GTPase by the Lymphoid blast crisis (Lbc) oncoprotein

  Lenoir, M., Sugawara, M., Kaur, J., Ball, L. J. & Overduin, M., 22 Aug 2014, In: Journal of Biological Chemistry. 289, 34, p. 23992-24004

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pleckstrin Homology Domains 100%
  • Blast Crisis 98%
  • GTP Phosphohydrolases 83%
  • Oncogene Proteins 81%
  • Guanine 70%
  8 Citations (Scopus)

  642 Downloads (Pure)
• 2013

  Hinged plakin domains provide specialized degrees of articulation in envoplakin, periplakin and desmoplakin

  Al-Jassar, C., Bernadό, P., Chidgey, M. & Overduin, M., 29 Jul 2013, In: PLoS ONE. 8, 7, e69767.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • envoplakin 100%
  • Plakins 86%
  • Desmoplakins 81%
  • spectrin 72%
  • Spectrin 45%
  14 Citations (Scopus)

  191 Downloads (Pure)

• Mechanistic basis of desmosome-targeted diseases

  Al-jassar, C., Bikker, H., Overduin, M. & Chidgey, M., 1 Nov 2013, In: Journal of Molecular Biology. 425, 21, p. 4006-4022

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Desmosomes 100%
  • Desmoplakins 48%
  • Mutation 43%
  • Plakophilins 26%
  • Electron Microscope Tomography 22%
  59 Citations (Scopus)

  319 Downloads (Pure)
• 2011

  Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain

  He, J., Scott, JL., Heroux, A., Roy, S., Lenoir, M., Overduin, M., Stahelin, RV. & Kutateladze, TG., 1 May 2011, In: Journal of Biological Chemistry. 286, 21, p. 18650-18657 8 p.

  Research output: Contribution to journal › Article

  • ADP-Ribosylation Factor 1 100%
  • Phosphatidylinositol 4-Phosphate 95%
  • phosphatidylinositol 4-phosphate 88%
  • Pleckstrin Homology Domains 79%
  • GTP Phosphohydrolases 66%
  59 Citations (Scopus)

• Secondary structure and (1)H, (13)C, (15)N resonance assignments of the Golgi-specific PH domain of FAPP1.

  Lenoir, M., Whittaker, SB. & Overduin, M., 8 Feb 2011, In: Biomolecular NMR Assignments.

  Research output: Contribution to journal › Article

  • Phosphatidylinositol 4-Phosphate 100%
  • phosphatidylinositol 4-phosphate 93%
  • Pleckstrin Homology Domains 83%
  • Secondary Structure 53%
  • Micelles 36%
• 2010

  Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains

  Lenoir, M., Coskun, U., Grzybek, M., Cao, X., Buschhorn, SB., James, J., Simons, K. & Overduin, M., 1 Apr 2010, In: EMBO Reports. 11, 4, p. 279-284 6 p.

  Research output: Contribution to journal › Article

  • Pleckstrin Homology Domains 100%
  • Phosphatidylinositol 4-Phosphate 79%
  • phosphatidylinositol 4-phosphate 74%
  • Phosphates 62%
  • Membranes 43%
  61 Citations (Scopus)

• The role of hydrophobic interactions in ankyrin-spectrin complex formation

  Kolondra, A., Lenoir, M., Wolny, M., Czogalla, A., Overduin, M., Sikorski, AF. & Grzybek, M., 1 Nov 2010, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1798, 11, p. 2084-2089 6 p.

  Research output: Contribution to journal › Article

  • Ankyrins 100%
  • Spectrin 93%
  • Hydrophobic and Hydrophilic Interactions 78%
  • Binding Site 49%
  • Binding Sites 27%
  8 Citations (Scopus)
• 2009

  Golgi protein FAPP2 tubulates membranes

  Cao, X., Coskun, U., Rossle, M., Buschhorn, SB., Grzybek, M., Dafforn, T., Lenoir, M., Overduin, M. & Simons, K., 25 Nov 2009, In: National Academy of Sciences. Proceedings. 106, 50, p. 21121-21125 5 p.

  Research output: Contribution to journal › Article

  • Phosphates 100%
  • Membranes 68%
  • Proteins 42%
  • Glucosylceramides 16%
  • Pleckstrin Homology Domains 15%
  50 Citations (Scopus)

• Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein of Legionella pneumophila

  Brombacher, E., Urwyler, S., Ragaz, C., Weber, SS., Kami, K., Overduin, M. & Hilbi, H., 1 Feb 2009, In: Journal of Biological Chemistry. 284, 8, p. 4846-4856 11 p.

  Research output: Contribution to journal › Article

  • Phosphate-Binding Proteins 100%
  • Phosphatidylinositol 4-Phosphate 93%
  • phosphatidylinositol 4-phosphate 86%
  • Guanine Nucleotide Exchange Factors 75%
  • Legionella pneumophila 74%
  193 Citations (Scopus)
• 2008

  Lipid interaction networks of peripheral membrane proteins revealed by data-driven micelle docking

  Dancea, F., Kami, K. & Overduin, M., 15 Jan 2008, In: Biophysical Journal. 94, 2, p. 515-24 10 p.

  Research output: Contribution to journal › Article

  • Micelles 100%
  • early endosome antigen 1 75%
  • Membrane Proteins 69%
  • Lipids 54%
  • Membranes 49%
  21 Citations (Scopus)
• 2006

  Cell migration and signalling specificity is determined by Rac1's phosphatidylserine recognition motif

  Finkielstein, CV., Overduin, M. & Capelluto, DGS., 20 Jul 2006, In: Journal of Biological Chemistry. 281, p. 27317-27326 10 p.

  Research output: Contribution to journal › Article

  • Phosphatidylserines 100%
  • Cell Movement 71%
  • Signal Transduction 67%
  • Guanosine 53%
  • Membranes 43%
  42 Citations (Scopus)

• Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate

  Cheever, M. L., Kutateladze, T. G. & Overduin, M., 1 Aug 2006, In: Protein Science. 15, 8, p. 1873-1882 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphatidylinositol 3-Phosphate 100%
  • phosphatidylinositol 3-phosphate 87%
  • 4-ethoxymethylene-2-phenyl-2-oxazoline-5-one 80%
  • Compound Mobility 41%
  • beta-Strand Protein Conformation 32%
  6 Citations (Scopus)

• Molecular mechanism of membrane docking by the Vam7p PX domain

  Lee, SA., Kovacs, J., Stahelin, RV., Cheever, ML., Overduin, M., Setty, TG., Burd, CG., Cho, W. & Kutateladze, TG., 13 Sept 2006, In: Journal of Biological Chemistry. 281, p. 37091-37101 11 p.

  Research output: Contribution to journal › Article

  • Phosphatidylinositols 100%
  • Static Electricity 66%
  • Lipid 64%
  • Membranes 56%
  • Vacuoles 39%
  38 Citations (Scopus)

• NMR spectra of oligosaccharides at ultra-high field (900 MHz) have better resolution than expected due to favourable molecular tumbling

  Blundell, CD., Thompson, M. & Overduin, M., 4 Sept 2006, In: Carbohydrate Research. 341, p. 1985-1991 7 p.

  Research output: Contribution to journal › Article

  • Hexasaccharide 100%
  • Oligosaccharides 80%
  • Oligosaccharide 67%
  • Carbohydrates 63%
  • NMR Spectrum 63%
  16 Citations (Scopus)

• Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain

  Tokonzaba, E., Capelluto, DG., Kutateladze, TG. & Overduin, M., 1 Mar 2006, In: Chem Biol Drug Design. 67, p. 230-237 8 p.

  Research output: Contribution to journal › Article

  • Pyridones 100%
  • Phosphoinositide 81%
  • Phosphopeptides 79%
  • Pyridone 78%
  • Phosphotyrosine 75%
  10 Citations (Scopus)

• Syntenin-1 is a new component of tetraspanin-entriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63

  Latysheva, N., Muratov, G., Rajesh, S., Padgett, M., Hotchin, N., Overduin, M. & Berditchevski, F., Oct 2006, In: Molecular and Cellular Biology. 20, p. 7707-7718 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Syntenins 100%
  • Tetraspanins 81%
  • PDZ Domains 17%
  • Cell Membrane 9%
  • Amino Acids 8%
  121 Citations (Scopus)
• 2005

  Investigation of the binding geometry of a peripheral membrane protein

  Brunecky, R., Lee, S., Rzepecki, PW., Overduin, M., Prestwich, GD., Kutateladze, AG. & Kutateladze, TG., 1 Jan 2005, In: Biochemistry. 44, p. 16064-16071 8 p.

  Research output: Contribution to journal › Article

  • Micelles 100%
  • Membrane Proteins 69%
  • Spin Labels 65%
  • Micelle 65%
  • dodecylphosphocholine 51%
  26 Citations (Scopus)

• Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch

  Lee, SA., Eyeson, R., Cheever, ML., Geng, J., Verkhusha, VV., Burd, C., Overduin, M. & Kutateladze, TG., 13 Sept 2005, In: National Academy of Sciences. Proceedings. 102, p. 13052-13057 6 p.

  Research output: Contribution to journal › Article

  • phosphatidylinositol 3-phosphate 100%
  • Histidine 69%
  • early endosome antigen 1 37%
  • Membranes 37%
  • Phosphatidylinositols 22%
  75 Citations (Scopus)