New Insights into the cellular response to complex DNA damage induced by proton beam therapy

Parsons, Jason (Principal Investigator)

Cancer and Genomic Sciences

Short title	New Insights into the cellular response to complex DNA damage induced by proton beam therapy
Status	Finished
Effective start/end date	1/04/23 → 30/06/25

Funding

Medical Research Council

4 Article
3 Review article

Radiosensitisation of Head and Neck Cancer Cells to Protons of Increasing LET Through Targeting DNA Double Strand Break Repair
Dufficy, E. R., Goula, A., Melia, E., Bellamy, A. & Parsons, J. L., 12 May 2026, In: Cells. 15, 10, 13 p., 879.
Research output: Contribution to journal › Article › peer-review

Open Access
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17 Downloads (Pure)
Radiobiological characterisation of a 28 MeV proton beam delivered by the MC-40 cyclotron
Fabbrizi, M. R., Hughes, J. R., Punshon, L. D., Hawkins, L., Sorokin, V., Ormrod, A., Melia, E., Vaidya, K., Rubbi, C. P., Phoenix, B., Hill, M. A. & Parsons, J. L., 21 Jul 2025, In: Cell Death Discovery. 11, 1, 8 p., 334.
Research output: Contribution to journal › Article › peer-review

Open Access
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87 Downloads (Pure)
Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation
Fabbrizi, M. R., Doggett, T. J., Hughes, J. R., Melia, E., Dufficy, E. R., Hill, R. M., Goula, A., Phoenix, B. & Parsons, J. L., 12 Jun 2024, In: Cell Death Discovery. 10, 1, 10 p., 282.
Research output: Contribution to journal › Article › peer-review

Open Access
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98 Downloads (Pure)