Research output
- 23 Article
- 23 results
Search results
-
2025
Imaging of Protein Assemblies up to 231 kDa in Tissues with Nano-DESI Mass Spectrometry
Hale, O. & Cooper, H., 30 Dec 2025, In: Analytical Chemistry. 97, 51, p. 28343-28352 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Infrared Photoactivation Enables nano-DESI MS of Protein Complexes in Tissue on a Linear Ion Trap Mass Spectrometer
Hale, O. J., Mize, T. H. & Cooper, H. J., 1 Jan 2025, In: Journal of the American Society for Mass Spectrometry. 36, 1, p. 146-152 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
2024
Laser capture microdissection and native mass spectrometry for spatially-resolved analysis of intact protein assemblies in tissue †
Hughes, J., Sisley, E. K., Hale, O. J. & Cooper, H. J., 7 Mar 2024, (E-pub ahead of print) In: Chemical Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Mass spectrometry imaging of SOD1 protein-metal complexes in SOD1G93A transgenic mice implicates demetalation with pathology
Hale, O. J., Wells, T. R., Mead, R. J. & Cooper, H. J., 8 Aug 2024, In: Nature Communications. 15, 1, 6518.Research output: Contribution to journal › Article › peer-review
Open AccessFile79 Downloads (Pure) -
2023
High-Throughput Deconvolution of Native Protein Mass Spectrometry Imaging Data Sets for Mass Domain Analysis
Hale, O., Cooper, H. J. & Marty, M. T., 19 Sept 2023, In: Analytical Chemistry. 95, 37, p. 14009-14015 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile237 Downloads (Pure) -
Tissue Washing Improves Native Ambient Mass Spectrometry Detection of Membrane Proteins Directly from Tissue
Sisley, E. K., Hale, O. J., Hughes, J. W. & Cooper, H. J., 26 Jul 2023, In: Journal of the American Chemical Society. 145, 29, p. 15658-15662 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile105 Downloads (Pure) -
2022
Mass Spectrometry Detection and Imaging of a Non-Covalent Protein-Drug Complex in Tissue from Orally Dosed Rats
Illes-Toth, E., Hale, O. J., Hughes, J. W., Strittmatter, N., Rose, J., Clayton, B., Sargeant, R., Jones, S., Dannhorn, A., Goodwin, R. J. A. & Cooper, H. J., 13 Jul 2022, (E-pub ahead of print) In: Angewandte Chemie (International Edition) . 61, 36, e202202075.Research output: Contribution to journal › Article › peer-review
Open AccessFile248 Downloads (Pure) -
Native Ambient Mass Spectrometry Enables Analysis of Intact Endogenous Protein Assemblies up to 145 kDa Directly from Tissue
Hale, O. J., Hughes, J. W., Sisley, E. K. & Cooper, H. J., 12 Apr 2022, In: Analytical Chemistry. 94, 14, p. 5608-5614 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile150 Downloads (Pure) -
Native Ambient Mass Spectrometry Imaging of Ligand-Bound and Metal-Bound Proteins in Rat Brain
Sisley, E. K., Hale, O. J., Styles, I. B. & Cooper, H. J., 9 Feb 2022, In: Journal of the American Chemical Society. 144, 5, p. 2120-2128 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile231 Downloads (Pure) -
Native Ambient Mass Spectrometry of an Intact Membrane Protein Assembly and Soluble Protein Assemblies Directly from Lens Tissue
Hale, O. J. & Cooper, H. J., 1 Aug 2022, In: Angewandte Chemie (International Edition) . 61, 31, e202201458.Research output: Contribution to journal › Article › peer-review
Open AccessFile188 Downloads (Pure) -
Native ambient mass spectrometry of intact protein assemblies directly from Escherichia coli colonies
Du, Y., May, R. C. & Cooper, H. J., 18 Jun 2022, In: Chemical Communications. 58, 48, p. 6857-6860 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile63 Downloads (Pure) -
Quantitative Characterization of Three Carbonic Anhydrase Inhibitors by LESA Mass Spectrometry
Illes-Toth, E., Stubbs, C. J., Sisley, E. K., Bellamy-Carter, J., Simmonds, A. L., Mize, T. H., Styles, I. B., Goodwin, R. J. A. & Cooper, H. J., 6 Jul 2022, In: Journal of the American Society for Mass Spectrometry. 33, 7, p. 1168-1175 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile168 Downloads (Pure) -
2021
Liquid extraction surface analysis mass spectrometry of ESKAPE pathogens
Havlikova, J., May, R., Styles, I. & Cooper, H., 1 Mar 2021, (E-pub ahead of print) In: Journal of the American Society for Mass Spectrometry. 32, 6, p. 1345-1351Research output: Contribution to journal › Article › peer-review
Open AccessFile227 Downloads (Pure) -
Native mass spectrometry imaging of proteins and protein complexes by nano-DESI
Hale, O. & Cooper, H., 16 Mar 2021, In: Analytical Chemistry. 93, 10, p. 4619–4627 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile345 Downloads (Pure) -
2020
Comprehensive LESA mass spectrometry imaging of intact proteins by integration of cylindrical FAIMS
Griffiths, R., Hughes, J., Abbatiello, S., Belford, M., Styles, I. & Cooper, H., 18 Feb 2020, In: Analytical Chemistry. 92, 4, p. 2885-2890 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)384 Downloads (Pure) -
Direct identification of bacterial and human proteins from infected wounds in living 3D skin models
Havlikova, J., May, R. C., Styles, I. B. & Cooper, H. J., 17 Jul 2020, In: Scientific Reports. 10, 1, 11900.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)228 Downloads (Pure) -
Electroporation and mass spectrometry: a new paradigm for in situ analysis of intact proteins direct from living yeast colonies
Kocurek, K., Havlikova, J., Buchan, E., Tanner, A., May, R. & Cooper, H., 4 Feb 2020, In: Analytical Chemistry. 92, 3, p. 2605-2611 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)273 Downloads (Pure) -
High-field asymmetric waveform ion mobility spectrometry and native mass spectrometry: analysis of intact protein assemblies and protein complexes
Hale, O. J., Illes-Toth, E., Mize, T. H. & Cooper, H. J., 19 May 2020, In: Analytical Chemistry. 92, 10, p. 6811-6816 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)234 Downloads (Pure) -
In situ mass spectrometry analysis of intact proteins and protein complexes from biological substrates
Hale, O. & Cooper, H., 3 Feb 2020, In: Biochemical Society Transactions. 48, 1, p. 317-326 10 p., BST20190793.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)210 Downloads (Pure) -
LESA Cyclic Ion Mobility Mass Spectrometry of Intact Proteins from Thin Tissue Sections
Sisley, E. K., Ujma, J., Palmer, M., Giles, K., Fernandez-Lima, F. A. & Cooper, H. J., 5 May 2020, In: Analytical Chemistry. 92, 9, p. 6321-6326 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)224 Downloads (Pure) -
Native LESA TWIMS-MSI: Spatial, Conformational, and Mass Analysis of Proteins and Protein Complexes
Hale, O. J., Sisley, E. K., Griffiths, R. L., Styles, I. B. & Cooper, H. J., 1 Apr 2020, In: Journal of the American Society for Mass Spectrometry. 31, 4, p. 873-879 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)294 Downloads (Pure) -
Native Mass Spectrometry Imaging and In Situ Top-Down Identification of Intact Proteins Directly from Tissue
Hale, O. J. & Cooper, H. J., 21 Aug 2020, (E-pub ahead of print) In: Journal of the American Society for Mass Spectrometry. 31, 12, p. 2531-2537Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)283 Downloads (Pure) -
Structural analysis of 14-3-3-ζ-derived phosphopeptides using electron capture dissociation mass spectrometry, traveling wave ion mobility spectrometry, and molecular modeling
Simmonds, A., Lopez-Clavijo, A., Winn, P., Russell, D., Styles, I. & Cooper, H., 23 Jan 2020, In: Journal of Physical Chemistry B. 124, 3, p. 461-469 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)254 Downloads (Pure)