Mucosal Lymphocytes in the Pathogenesis of Primary Sclerosing Cholangitis

Research output

Research output per year 2006 2008 2009 2011 2014

• 18 Article

Research output per year

Research output per year

Search results

• 2014

  Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis

  Afford, S. C., Humphreys, E. H., Reid, D. T., Russell, C. L., Banz, V. M., Oo, Y. H., Vo, T., Jenne, C., Adams, D. H. & Eksteen, B., May 2014, In: Hepatology. 59, 5, p. 1932-1943 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Cell Adhesion Molecule-1 100%
  • Epithelium 66%
  • T-Lymphocytes 53%
  • Apoptosis 52%
  • Inflammation 51%
  34 Citations (Scopus)
• 2013

  Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

  Liu, J. Z., Hov, J. R., Folseraas, T., Ellinghaus, E., Rushbrook, S. M., Doncheva, N. T., Andreassen, O. A., Weersma, R. K., Weismüller, T. J., Eksteen, B., Invernizzi, P., Hirschfield, G. M., Gotthardt, D. N., Pares, A., Ellinghaus, D., Shah, T., Juran, B. D., Milkiewicz, P., Rust, C., Schramm, C., & 31 othersMüller, T., Srivastava, B., Dalekos, G., Nöthen, M. M., Herms, S., Winkelmann, J., Mitrovic, M., Braun, F., Ponsioen, C. Y., Croucher, P. J. P., Sterneck, M., Teufel, A., Mason, A. L., Saarela, J., Leppa, V., Dorfman, R., Alvaro, D., Floreani, A., Onengut-Gumuscu, S., Rich, S. S., Thompson, W. K., Schork, A. J., Næss, S., Thomsen, I., Mayr, G., König, I. R., Hveem, K., Cleynen, I., Gutierrez-Achury, J., Ricaño-Ponce, I. & UK-PSCSC Consortium, Jun 2013, In: Nature Genetics. 45, 6, p. 670-5 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Sclerosing Cholangitis 100%
  • Immune System Diseases 83%
  • Inflammatory Bowel Diseases 18%
  • Population Control 11%
  • HLA Antigens 10%
  233 Citations (Scopus)
• 2012

  CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

  Oo, Y. H., Banz, V., Kavanagh, D., Liaskou, E., Withers, D. R., Humphreys, E., Reynolds, G. M., Lee-Turner, L., Kalia, N., Hubscher, S. G., Klenerman, P., Eksteen, B. & Adams, D. H., Nov 2012, In: Journal of Hepatology. 57, 5, p. 1044-1051 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Th17 Cells 100%
  • Liver 62%
  • Interleukin-17 38%
  • Bile Ducts 36%
  • Helper-Inducer T-Lymphocytes 24%
  115 Citations (Scopus)

  268 Downloads (Pure)
• 2011

  [Acute liver failure after administration of paracetamol at the maximum recommended daily dose in adults].

  Claridge, L., Eksteen, J., Smith, A., Shah, T. & Holt, A., 27 Jul 2011, In: Praxis. 100, 15, p. 923-6 4 p.

  Research output: Contribution to journal › Article

  Open Access
  1 Citation (Scopus)

• Clonal Analysis Reveals Uniformity in the Molecular Profile and Lineage Potential of CCR9+ and CCR9- Thymus-Settling Progenitors

  Desanti, G., Jenkinson, W., Parnell, S., Boudil, A., Gautreau-Rolland, L., Eksteen, J., Ezine, S., Lane, P., Jenkinson, E. & Anderson, G., 18 Mar 2011, In: Journal of Immunology. 186, 9, p. 5227-5235 9 p.

  Research output: Contribution to journal › Article

  • Thymus Gland 100%
  • T-Lymphocytes 40%
  • Gene Expression 11%
  • Chemokine Receptors 10%
  • Multiplex Polymerase Chain Reaction 10%
  13 Citations (Scopus)

• Infections and the Liver

  Eksteen, J., 1 Jan 2011, In: Digestive Diseases. 29, 2, p. 184-190 7 p.

  Research output: Contribution to journal › Article

  • Liver 100%
  • Infections 92%
  • Hepatitis 91%
  • Hepacivirus 89%
  • Interferons 89%
  3 Citations (Scopus)
• 2010

  Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver

  Oo, Y. H., Weston, C., Lalor, P., Curbishley, S., Withers, D., Reynolds, G., Shetty, S., Harki, J., Shaw, J., Eksteen, J., Hubscher, S., Walker, L. & Adams, D., 15 Mar 2010, In: Journal of Immunology. 184, 6, p. 2886-2898 13 p.

  Research output: Contribution to journal › Article

  • Regulatory T-Lymphocytes 100%
  • Liver 51%
  • Dendritic Cells 51%
  • Chemokine Receptors 32%
  • Ligands 30%
  153 Citations (Scopus)
• 2009

  Differential ferritin expression is associated with iron deficiency in coeliac disease.

  Sharma, N., Begum, J., Eksteen, J., Elagib, A., Brookes, M., Cooper, B., Tselepis, C. & Iqbal, T., 1 Jul 2009, In: European Journal of Gastroenterology & Hepatology. 21, 7, p. 794-804 11 p.

  Research output: Contribution to journal › Article

  • Celiac Disease 100%
  • Ferritins 94%
  • Iron 75%
  • Lymphocytes 16%
  • Enterocytes 14%
  19 Citations (Scopus)

• Gut homing receptors on CD8 T-cells are retinoic acid dependent and not maintained by Liver dendritic or stellate cells.

  Eksteen, J., Mora, JR., Shepherd, E., Henderson, NC., Lee-Turner, L., Villablanca, EJ., Curbishley, S., Aspinall, AI., von Andrian, UH. & Adams, D., 19 Feb 2009, In: Gastroenterology. 137, 1, p. 320-329 10 p.

  Research output: Contribution to journal › Article

  • CD8 receptor 100%
  • Tretinoin 60%
  • Dendritic Cells 52%
  • T-Lymphocytes 36%
  • Sclerosing Cholangitis 31%
  97 Citations (Scopus)

• The Survival of Memory CD4(+) T Cells within the Gut Lamina Propria Requires OX40 and CD30 Signals

  Withers, D., Jaensson, E., Gaspal, F., McConnell, F., Eksteen, J., Anderson, G., Agace, WW. & Lane, P., 1 Oct 2009, In: Journal of Immunology. 183, 8, p. 5079-5084 6 p.

  Research output: Contribution to journal › Article

  • Mucous Membrane 100%
  • T-Lymphocytes 77%
  • Small Intestine 38%
  • Immunization 35%
  • Lymphoid Tissue 22%
  35 Citations (Scopus)
• 2008

  A role for the integrin α6 β1 in the differential distribution of CD4 and CD8 T-cell subsets within the rheumatoid synovium

  Haworth, O., Hardie, D., Burman, A., Rainger, G., Eksteen, J., Adams, D., Salmon, M., Nash, G. & Buckley, C., 4 Apr 2008, In: Rheumatology. 47, 9, p. 1329-1334 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Synovial Membrane 100%
  • T-Lymphocyte Subsets 91%
  • Integrins 80%
  • T-Lymphocytes 52%
  • Synovial Fluid 32%
  13 Citations (Scopus)

• CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.

  Miles, A., Liaskou, E., Eksteen, J., Lalor, P. & Adams, D., 1 May 2008, In: American journal of physiology. Gastrointestinal and liver physiology. 294, 5, p. G1257-67

  Research output: Contribution to journal › Article › peer-review

  • integrin beta7 100%
  • Integrin alpha4 95%
  • Cell Adhesion Molecule-1 68%
  • Chemokines 45%
  • Lymphocytes 33%
  48 Citations (Scopus)

• Immunology of the gut and liver: a love/hate relationship.

  Adams, D., Eksteen, J. & Curbishley, S., 1 Jun 2008, In: Gut. 57, 6, p. 838-48 11 p.

  Research output: Contribution to journal › Article
  54 Citations (Scopus)

• Lymphocyte homing and its role in the pathogenesis of IBD

  Eksteen, J., Liaskou, E. & Adams, D., 1 Jan 2008, In: Inflammatory Bowel Diseases. 14, 9, p. 1298-1312 15 p.

  Research output: Contribution to journal › Article

  • Inflammatory Bowel Diseases 100%
  • Lymphocytes 73%
  • Crohn Disease 57%
  • Ulcerative Colitis 44%
  • Inflammation 35%
  42 Citations (Scopus)

• Mechanisms of Disease: the evolving understanding of liver allograft rejection

  Eksteen, J. & Neuberger, J., 1 Jan 2008, In: Nature Clinical Practice Gastroenterology & Hepatology. 5, 4, p. 209-219 11 p.

  Research output: Contribution to journal › Article

  • Allografts 100%
  • Liver 58%
  • Lymphocytes 52%
  • Transplantation Tolerance 52%
  • Organ Transplantation 41%
  9 Citations (Scopus)

• Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans

  Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, J., Tian, J., Coombes, JL., Berg, PL., Davidsson, T., Powrie, F., Johansson-Lindbom, B. & Agace, WW., 11 Aug 2008, In: The Journal of Experimental Medicine. 205, 9, p. 2139-2149 11 p.

  Research output: Contribution to journal › Article

  • Dendritic Cells 100%
  • Lymph Nodes 50%
  • Mucous Membrane 32%
  • CC chemokine receptor 9 19%
  • T-Lymphocytes 18%
  457 Citations (Scopus)
• 2007

  Immune-mediated liver injury.

  Eksteen, J., Afford, S., Wigmore, SJ., Holt, A. & Adams, D., 1 Nov 2007, In: Seminars in Liver Disease. 27, 4, p. 351-66 16 p.

  Research output: Contribution to journal › Article

  • Antigens 100%
  • Hepatocytes 88%
  • Leukocytes 83%
  • Liver 81%
  • Wounds and Injuries 76%
  47 Citations (Scopus)
• 2006

  Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

  Mora, JR., Eksteen, J., Iwata, M., Song, S-Y., Junt, T., Senman, B., Otipoby, KL., Yokota, A., Takeuchi, H., Ricciardi-Castagnoli, P., Rajewski, K., Adams, D. & Von Andrian, UH., 17 Nov 2006, In: Science. 314, p. 1157-60 4 p.

  Research output: Contribution to journal › Article

  • Lymphoid Tissue 100%
  • Immunoglobulin A 86%
  • Dendritic Cells 83%
  • B-Lymphocytes 71%
  • Tretinoin 57%
  720 Citations (Scopus)