MICA Potential of P2X7 receptor antagonism to attenuate the adverse consequences of neurotrauma (PROTECT)

Barnes, Nicholas (Principal Investigator)
Bach, Simon (Co-Investigator)
Belli, Tony (Co-Investigator)
Di Pietro, Valentina (Co-Investigator)
Brock, Kristian (Co-Investigator)
Barton, Darren (Co-Investigator)
Logan, Ann (Co-Investigator)
Lax, Sian (Co-Investigator)
Lax, Sian (Co-Investigator)
Billingham, Lucinda (Researcher)
Bowden, Sarah (Co-Investigator)
Bowden, Sarah (Co-Investigator)

Short title	MICA Potential of P2X7 receptor antagonism to attenuate the adverse consequences of neurotrauma (PROTECT)
Status	Finished
Effective start/end date	1/12/20 → 30/11/23

Funding

Medical Research Council

P2X7R mediated IL-1β release by human brain tissue: impact of CNS-penetrant drugs with potential to treat inflammatory brain disease
Cowley, J., Harrison, N., Pegg, A., Chan, H., Li, Z., Kaur, A., Welsh, E., Brewin, A., Yam-Puc, J. C., Fensome, G., Broome, E., Morano, I. M., Jinks, E., Grafton, G., Cooper, A. J., Ahmed, Z., Stevens, A. R., Anderson, F. G., Wykes, V. & Chelvarajah, R. & 18 others, Tsermoulas, G., Ughratdar, I., Zisakis, A., Petrik, V., O'Halloran, P. J., Davies, D. J., Land, T., Chowdhury, Y. A., Sher, Z., Yakoub, K. M., Bergin, C., Galloway, L., Upthegrove, R., Brady, C. A., Gordon, J., Qureshi, O., Belli, A. & Barnes, N., 19 Feb 2026, (E-pub ahead of print) In: Brain. awag068.
Research output: Contribution to journal › Article › peer-review

Open Access
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Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?
Qureshi, O., Cowley, J., Pegg, A., Cooper, A. J., Gordon, J., Brady, C. A., Belli, A., Butterworth, S., Upthegrove, R., Andrews, N. & Barnes, N. M., 28 Jul 2025, (E-pub ahead of print) In: British Journal of Pharmacology.
Research output: Contribution to journal › Review article › peer-review

Open Access
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