Research output per year
Research output per year
- 10 results
Search results
-
2024
Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis
Gao, S., Wu, F., Gurcha, S. S., Batt, S. M., Besra, G. S., Rao, Z. & Zhang, L., 15 Mar 2024, (E-pub ahead of print) In: Nature Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2023
Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis
Batt, S. M., Toth, S., Rodriguez, B., Abrahams, K. A., Veerapen, N., Chiodarelli, G., Cox, L. R., Moynihan, P. J., Lelievre, J., Fütterer, K. & Besra, G. S., 23 Jan 2023, In: Microbiology. 169, 1, 001288.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure) -
DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid
Abrahams, K. A., Batt, S. M., Gurcha, S. S., Veerapen, N., Bashiri, G. & Besra, G. S., 28 Jun 2023, In: Nature Communications. 14, 1, 10 p., 3828.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Downloads (Pure) -
2021
Chemical insights into the search for MAIT cells activators
Veerapen, N., Hobrath, J., Besra, A. K. & Besra, G. S., Jan 2021, In: Molecular immunology. 129, p. 114-120 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile204 Downloads (Pure) -
Discovery of novel thiophene-arylamide derivatives as DprE1 inhibitors with potent antimycobacterial activities
Wang, P., Batt, S. M., Wang, B., Fu, L., Qin, R., Lu, Y., Li, G., Besra, G. S. & Huang, H., 13 May 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 6241-6261 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile245 Downloads (Pure) -
The multi-target aspect of an MmpL3 inhibitor: the BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation
Moorey, A. R., Cabanillas, A., Batt, S. M., Ghidelli-Disse, S., Urones, B., Sanz, O., Lelievre, J., Bantscheff, M., Cox, L. R. & Besra, G. S., Dec 2021, In: The Cell Surface. 7, 12 p., 100068.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Downloads (Pure) -
2020
Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183
Abrahams, K. A., Hu, W., Li, G., Lu, Y., Richardson, E. J., Loman, N. J., Huang, H. & Besra, G. S., Dec 2020, In: The Cell Surface. 6, 9 p., 100040.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)119 Downloads (Pure) -
Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline
Burke, C., Jankute, M., Moynihan, P., Gonzalez Del Rio, R., Li, X., Esquivias, J., Lelièvre, J., Cox, J. A. G., Sacchettini, J. & Besra, G. S., 16 Oct 2020, In: FASEB BioAdvances. 2, 10, p. 600-612 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile194 Downloads (Pure) -
Mycobacterial drug discovery
Abrahams, K. A. & Besra, G. S., 1 Dec 2020, In: RSC Medicinal Chemistry. 11, 12, p. 1354-1365Research output: Contribution to journal › Article › peer-review
Open AccessFile150 Downloads (Pure) -
Tuberculosis diagnostics: overcoming ancient challenges with modern solutions
MacGregor-Fairlie, M., Wilkinson, S., Besra, G. S. & Goldberg Oppenheimer, P., 1 Dec 2020, In: Emerging topics in life sciences. 4, 4, p. 423-436 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile142 Downloads (Pure)