MICA: Addressing the burgeoning problem of tuberculosis: Exploiting phenotypic hits to identify new protein targets for drug discovery

Besra, Del (Principal Investigator)
Cox, Liam (Co-Investigator)
Futterer, Klaus (Co-Investigator)

Short title	MICA: Addressing the burgeoning problem of tuberculosis: Exploiting phenotypic hits to identify new protein targets for drug discovery
Status	Finished
Effective start/end date	1/04/18 → 31/03/22

Funding

Medical Research Council

9 Article
2 Review article

Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis
Batt, S. M., Toth, S., Rodriguez, B., Abrahams, K. A., Veerapen, N., Chiodarelli, G., Cox, L. R., Moynihan, P. J., Lelievre, J., Fütterer, K. & Besra, G. S., 23 Jan 2023, In: Microbiology. 169, 1, 001288.
Research output: Contribution to journal › Article › peer-review

Open Access
File
12 Downloads (Pure)
DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid
Abrahams, K. A., Batt, S. M., Gurcha, S. S., Veerapen, N., Bashiri, G. & Besra, G. S., 28 Jun 2023, In: Nature Communications. 14, 1, 10 p., 3828.
Research output: Contribution to journal › Article › peer-review

Open Access
File
8 Downloads (Pure)
Chemical insights into the search for MAIT cells activators
Veerapen, N., Hobrath, J., Besra, A. K. & Besra, G. S., Jan 2021, In: Molecular immunology. 129, p. 114-120 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
169 Downloads (Pure)