MAGPIE Project: The Structure and Assembly of the Mycobacterial Cell Envelope

Research output

Research output per year 2006 2006 2008 2009 2017

• 26 Article

Research output per year

Research output per year

Search results

• 2017

  The role of hydrophobicity in tuberculosis evolution and pathogenicity

  Jankute, M., Nataraj, V., Lee, O. Y-C., Wu, H. H. T., Ridell, M., Garton, N. J., Barer, M. R., Minnikin, D. E., Bhatt, A. & Besra, G. S., 2 May 2017, In: Scientific Reports. 7, 1315.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mycobacterium kansasii 100%
  • Hydrophobic and Hydrophilic Interactions 87%
  • Mycobacterium tuberculosis 77%
  • Virulence 69%
  • Tuberculosis 65%
  33 Citations (Scopus)

  191 Downloads (Pure)
• 2010

  Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway

  Kalscheuer, R., Syson, K., Veeraraghavan, U., Weinrick, B., Biermann, KE., Liu, Z., Sacchettini, JC., Besra, G., Bornemann, S. & Jacobs, WR., 1 May 2010, In: Nature Chemical Biology. 6, 5, p. 376-384 9 p.

  Research output: Contribution to journal › Article

  • maltose 1-phosphate 100%
  • Glucans 61%
  • Poisoning 47%
  • Mycobacterium tuberculosis 45%
  • Trehalose 42%
  116 Citations (Scopus)

• Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis

  Kalscheuer, R., Weinrick, B., Veeraraghavan, U., Besra, G. & Jacobs, WR., 14 Dec 2010, In: National Academy of Sciences. Proceedings. 107, 50, p. 21761-6 6 p.

  Research output: Contribution to journal › Article

  • Trehalose 100%
  • ATP-Binding Cassette Transporters 86%
  • trehalose monomycolate 85%
  • Mycobacterium tuberculosis 71%
  • Virulence 63%
  106 Citations (Scopus)
• 2009

  Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity

  Guillonneau, C., Mintern, JD., Hubert, FX., Hurt, AC., Besra, G., Porcelli, S., Barr, IG., Doherty, PC., Godfrey, DI. & Turner, SJ., 1 Mar 2009, In: National Academy of Sciences. Proceedings. 106, 9, p. 3330-3335 6 p.

  Research output: Contribution to journal › Article

  • alpha-galactosylceramide 100%
  • Natural Killer T-Cells 79%
  • Influenza A virus 72%
  • Cytotoxic T-Lymphocytes 71%
  • Orthomyxoviridae 66%
  106 Citations (Scopus)

• Glycosylation of the phosphate binding protein, PstS, in Streptomyces coelicolor by a pathway that resembles protein O-mannosylation in eukaryotes

  Wehmeier, S., Varghese, AS., Gurcha, S., Tissot, B., Panico, M., Hitchen, P., Morris, HR., Besra, G., Dell, A. & Smith, MCM., 1 Jan 2009, In: Molecular Microbiology. 71, 2, p. 421-433 13 p.

  Research output: Contribution to journal › Article

  • Polyprenols 100%
  • Phosphate-Binding Proteins 97%
  • Streptomyces coelicolor 83%
  • Mannose 64%
  • Eukaryota 57%
  38 Citations (Scopus)

• Sequence and analysis of a plasmid-encoded mercury resistance operon from Mycobacterium marinum identifies MerH, a new mercuric ion transporter.

  Schué, M., Dover, LG., Besra, G., Parkhill, J. & Brown, NL., 1 Jan 2009, In: Journal of Bacteriology. 191, 1, p. 439-44 6 p.

  Research output: Contribution to journal › Article

  • mercuric reductase 100%
  • Mycobacterium marinum 81%
  • Ion Transport 61%
  • Mercury 58%
  • Operon 56%
  27 Citations (Scopus)

• Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis

  Usha, V., Dover, LG., Roper, DI., Futterer, K. & Besra, G., 1 Apr 2009, In: Acta Crystallographica Section D Biological Crystallography. 65, 4, p. 383-387 5 p.

  Research output: Contribution to journal › Article

  • diaminopimelate epimerase 100%
  • Diaminopimelic Acid 70%
  • Mycobacterium tuberculosis 45%
  • Peptidoglycan 22%
  • Bacillus anthracis 12%
  16 Citations (Scopus)

• Synthesis of deoxygenated alpha(1 -> 5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis

  Pathak, AK., Pathak, V., Suling, WJ., Riordan, JR., Gurcha, S., Besra, G. & Reynolds, RC., 1 Jan 2009, In: Bioorganic & Medicinal Chemistry. 17, 2, p. 872-881 10 p.

  Research output: Contribution to journal › Article

  • arabinosyltransferase 100%
  • arabinofuranose 98%
  • Disaccharides 64%
  • Disaccharide 50%
  • Mycobacterium tuberculosis 47%
  19 Citations (Scopus)
• 2008

  Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

  Im, JS., Kang, T-J., Lee, S-B., Kim, C-H., Venkataswamy, MM., Serfass, E., Chen, PA., Illarionov, P., Besra, G., Jacobs, WR., Chae, G-T. & Porcelli, SA., 1 Jan 2008, In: Clin. Immunol. 127, p. 214-224 11 p.

  Research output: Contribution to journal › Article

  • Natural Killer T-Cells 100%
  • Tuberculosis 58%
  • Leprosy 41%
  • Infections 39%
  • Mycobacterium leprae 32%
  33 Citations (Scopus)

• Antimycobacterial activity and mechanism of action of NAS-91

  Gratraud, P., Surolia, N., Besra, G., Surolia, A. & Kremer, L., 1 Mar 2008, In: Antimicrobial Agents and Chemotherapy. 52, 3, p. 1162-1166 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Oleic Acid 100%
  • Mycolic Acids 66%
  • Stearoyl-CoA Desaturase 64%
  • Antimalarials 47%
  19 Citations (Scopus)

• Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization.

  Usha, V., Dover, LG., Roper, DL. & Besra, G., 1 Mar 2008, In: FEMS Microbiology Letters. 280, 1, p. 57-63 7 p.

  Research output: Contribution to journal › Article

  • diaminopimelate epimerase 100%
  • Racemases and Epimerases 70%
  • Mycobacterium tuberculosis 45%
  • Serine 45%
  • Cysteine 43%
  12 Citations (Scopus)

• EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR

  Molle, V., Reynolds, RC., Alderwick, L., Besra, G., Cozzone, AJ., Fuetterer, K. & Kremer, L., 1 Mar 2008, In: Biochemical Journal. 410, p. 309-317 9 p.

  Research output: Contribution to journal › Article

  • Threonine 100%
  • Mycobacterium tuberculosis 87%
  • Arabinan 72%
  • Phosphotransferases 69%
  • NU2058 51%
  20 Citations (Scopus)

• Exploring the substrate specificity of a mycobacterial polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase

  Tam, PH., Besra, G. & Lowary, TL., 25 Jan 2008, In: ChemBioChem. 9, 2, p. 267-78 12 p.

  Research output: Contribution to journal › Article

  • alpha 1,6-mannosyltransferase 100%
  • Polyprenols 86%
  • Polyprenol 78%
  • Substrate Specificity 53%
  • Mannan 44%
  18 Citations (Scopus)

• Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.

  Mishra, A. K., Alderwick, L., Rittmann, D., Wang, C., Bhatt, A., Jacobs, WR., Takayama, K., Eggeling, L. & Besra, G., 1 Jun 2008, In: Molecular Microbiology. 68, 6, p. 1595-613 19 p.

  Research output: Contribution to journal › Article

  • lipomannan 100%
  • lipoarabinomannan 78%
  • Corynebacterium glutamicum 78%
  • Mycobacterium smegmatis 36%
  • phosphatidylinositol dimannoside 27%
  48 Citations (Scopus)

• Serum lipids regulate dendritic cell CD1 expression and function

  Leslie, DS., Dascher, CC., Cembrola, K., Townes, MA., Hava, DL., Hugrndubler, LC., Mueller, E., Fox, L., Roura-Mir, C., Moody, DB., Vincent, MS., Gumperz, JE., Illarionov, P., Besra, G., reynolds, CG. & Brenner, MB., 1 Nov 2008, In: Immunology. 125, 3, p. 289-301 13 p.

  Research output: Contribution to journal › Article

  • Dendritic Cells 100%
  • Lipids 73%
  • Serum 50%
  • T-Lymphocytes 49%
  • lysophosphatidic acid 42%
  55 Citations (Scopus)

• Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant

  Mishra, A. K., Klein, C., Gurcha, S., Alderwick, L., Babu, P., Hitchen, PG., Morris, HR., Dell, A., Besra, G. & Eggeling, L., 1 Aug 2008, In: Antonie van Leeuwenhoek. 94, 2, p. 277-87 11 p.

  Research output: Contribution to journal › Article

  • lipomannan 100%
  • Corynebacterium glutamicum 78%
  • Lipopolysaccharides 45%
  • lipoarabinomannan 31%
  • Phosphatidylinositols 22%
  24 Citations (Scopus)

• The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction

  Appelmelk, BJ., den Dunnan, J., Driessen, NN., Ummels, R., Pak, M., Nigou, J., Larrouy-Maumus, G., Gurcha, S., Movahedzadeh, F., Geurtsen, J., Brown, EJ., Eysink Smeets, MM., Besra, G., Willemsen, PTJ., Lowary, TL., van Kooyk, Y., Maaskant, JJ., Stoker, NG., van der Ley, P., Puzo, G., & 6 othersVandenbroucke-Grauls, CMJE., Wieland, CW., van der Poll, T., Geijtenbeek, T., van der Sar, AM. & Bitter, W., 1 Apr 2008, In: Cellular Microbiology. 10, 4, p. 930-44 15 p.

  Research output: Contribution to journal › Article

  • lipoarabinomannan 100%
  • Mannose 77%
  • Mycobacterium 72%
  • Mycobacterium bovis 54%
  • DC-specific ICAM-3 grabbing nonintegrin 53%
  88 Citations (Scopus)

• Tuberculosis: a balanced diet of lipids and carbohydrates.

  Bhowruth, V., Alderwick, L., Brown, A., Bhatt, A. & Besra, G., 1 Aug 2008, In: Biochemical Society Transactions. 36, Pt 4, p. 555-65 11 p.

  Research output: Contribution to journal › Article

  • Ethambutol 100%
  • Macromolecular Structure 82%
  • Peptidoglycan 81%
  • Drug Target 72%
  • Carbohydrates 55%
  14 Citations (Scopus)
• 2007

  Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library

  Bhowruth, V., Brown, A., Senior, SJ., Snaith, J. & Besra, G., 15 Oct 2007, In: Bioorganic & Medicinal Chemistry Letters. 17, 20, p. 5643 1 p.

  Research output: Contribution to journal › Article

  • thiolactomycin 100%
  • Thiolactomycin 92%
  • diphenyl 62%
  • Biphenyl 50%
  • Libraries 44%
  18 Citations (Scopus)
• 2006

  Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism.

  Alderwick, L., Dover, L., Seidel, M., Gande, R., Sahm, H., Eggeling, L. & Besra, G., 1 Nov 2006, In: Glycobiology. 16, 11, p. 1073-81 9 p.

  Research output: Contribution to journal › Article

  • araban 100%
  • Corynebacterium glutamicum 80%
  • Arabinose 75%
  • Arabinan 59%
  • Mycolic Acid 54%
  30 Citations (Scopus)

• Characterisation of putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG

  Anderton, MC., Bhakta, S., Besra, G., Jeavons, P., Eltis, LD. & Sim, E., 1 Jan 2006, In: Molecular Microbiology. 59, p. 181-192 12 p.

  Research output: Contribution to journal › Article

  • Arylamine N-Acetyltransferase 100%
  • Operon 66%
  • Mycobacterium bovis 65%
  • 2,3-dihydroxybiphenyl 36%
  • Acetyltransferases 23%
  42 Citations (Scopus)

• Identification of a novel arabinofuranosyl transferase (aftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis

  Alderwick, L., Seidel, M., Sahm, H., Besra, G. & Eggeling, L., 11 Apr 2006, In: Journal of Biological Chemistry. 281, p. 15653-15662 10 p.

  Research output: Contribution to journal › Article

  • araban 100%
  • Arabinan 88%
  • Galactan 80%
  • Galactans 78%
  • Transferases 55%
  125 Citations (Scopus)

• Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis

  Alderwick, L., Molle, V., Kremer, L., Cuzzone, AJ., Dafforn, T., Besra, G. & Futterer, K., 6 Feb 2006, In: National Academy of Sciences. Proceedings. 103, 8, p. 2558-2563 6 p.

  Research output: Contribution to journal › Article

  • Molecular Structure 100%
  • Response Elements 90%
  • Mycobacterium tuberculosis 80%
  • Phosphotransferases 64%
  • arabinosyltransferase 56%
  58 Citations (Scopus)

• The 5-dexoy-5methylthio-xylofuranose residue in mycobacterial lipoarabinomannan. Absolute stereochemistry, linkage position, confirmation and immunomodulatory activity

  Joe, M., Sun, D., Taha, H., Completo, GC., Croudac, JE., Lammas, D., Besra, G. & Lowary, TL., 19 Apr 2006, In: Journal of the American Chemical Society. 128, p. 5059-5072 14 p.

  Research output: Contribution to journal › Article

  • Glycoconjugates 100%
  • Stereochemistry 88%
  • Lipoarabinomannan 80%
  • Cytokines 79%
  • Nuclear magnetic resonance spectroscopy 72%
  50 Citations (Scopus)

• The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation

  Molle, V., Brown, A., Besra, G., Cozzone, AJ. & Kremer, L., 11 Aug 2006, In: Journal of Biological Chemistry. 281, p. 30094 - 30193 100 p.

  Research output: Contribution to journal › Article

  • Type II Fatty Acid Synthase 100%
  • Thr-Ser 76%
  • Mycobacterium tuberculosis 51%
  • Protein Kinases 49%
  • Fatty Acid 42%
  87 Citations (Scopus)

• Use of a codon alteration strategy in a novel approach to cloning the mycobacterium tuberculosis diaminopimelic acid epimerase

  Usha, V., Dover, L., Roper, DL., Lloyd, AJ. & Besra, G., 1 Sept 2006, In: FEMS Microbiology Letters. 262, p. 39-47 9 p.

  Research output: Contribution to journal › Article

  • diaminopimelate epimerase 100%
  • Codon 45%
  • Mycobacterium tuberculosis 45%
  • Organism Cloning 42%
  • Silent Mutation 32%
  6 Citations (Scopus)