Lymphocyte Ligands for the Endothelial Adhesion Molecule Vascular Adhesion Protein-1

Research output

Research output per year 2007 2009 2013 2015

• 26 Article

Research output per year

Research output per year

Search results

• 2015

  Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis

  Weston, C. J., Shepherd, E. L., Claridge, L. C., Rantakari, P., Curbishley, S., Tomlinson, J. W., Hubscher, S. G., Reynolds, G. M., Aalto, K., Anstee, Q. M., Jalkanen, S., Salmi, M., Smith, D. J., Day, C. P. & Adams, D., Feb 2015, In: Journal of Clinical Investigation. 125, 2, p. 501-20 20 p.

  Research output: Contribution to journal › Article › peer-review

  • Fibrosis 100%
  • Inflammation 79%
  • Blood Vessels 79%
  • Liver 69%
  • Proteins 49%
  95 Citations (Scopus)

  249 Downloads (Pure)
• 2014

  Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner

  Fletcher, N. F., Sutaria, R., Jo, J., Barnes, A., Blahova, M., Meredith, L. W., Cosset, F., Curbishley, S. M., Adams, D. H., Bertoletti, A. & Mckeating, J. A., 1 Apr 2014, In: Hepatology. 59, 4, p. 1320-1330

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Virus Internalization 100%
  • Hepacivirus 74%
  • Tumor Necrosis Factor-alpha 57%
  • Macrophages 56%
  • Innate Immunity 24%
  33 Citations (Scopus)

  204 Downloads (Pure)

• Evaluation of serum lysyl oxidase as a blood test for colorectal cancer

  Ward, S., Weston, C., Hepburn, E., Damery, S., Hejmadi, R., Morton, D., Middleton, G., Ismail, T. & Adams, D., 1 Jun 2014, In: European Journal of Surgical Oncology. 40, 6, p. 731-8 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein-Lysine 6-Oxidase 100%
  • Hematologic Tests 72%
  • Colorectal Neoplasms 55%
  • Serum 31%
  • Polyps 12%
  2 Citations (Scopus)

• Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication

  Rowe, I. A., Galsinh, S. K., Wilson, G. K., Parker, R., Durant, S., Lazar, C., Branza-Nichita, N., Bicknell, R., Adams, D. H., Balfe, P. & McKeating, J. A., Feb 2014, In: Hepatology. 59, 2, p. 375–384

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bone Morphogenetic Protein 4 100%
  • Virus Replication 70%
  • Hepacivirus 64%
  • Endothelium 61%
  • Liver 35%
  25 Citations (Scopus)

  307 Downloads (Pure)
• 2013

  An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells

  Karim, S., Liaskou, E., Hadley, S., Youster, J., Faint, J., Adams, D. H. & Lalor, P. F., Mar 2013, In: Toxicological Sciences. 132, 1, p. 131-41 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ethanol 100%
  • Lymphocytes 61%
  • Liver 61%
  • Alcoholic Liver Diseases 55%
  • In Vitro Techniques 51%
  17 Citations (Scopus)

  1 Downloads (Pure)

• Cellular localization and trafficking of vascular adhesion protein-1 as revealed by an N-terminal GFP fusion protein

  Weston, C. J., Shepherd, E. L. & Adams, D. H., Jun 2013, In: Journal of Neural Transmission. 120, 6, p. 951-61 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Blood Vessels 100%
  • Proteins 62%
  • carbamylhydrazine 20%
  • methylamine 17%
  • glucose-regulated proteins 16%
  6 Citations (Scopus)

  183 Downloads (Pure)

• Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment

  Lalor, P. F., Herbert, J., Bicknell, R. & Adams, D. H., 1 Mar 2013, In: American journal of physiology. Gastrointestinal and liver physiology. 304, 5, p. G469-78

  Research output: Contribution to journal › Article › peer-review

  • Platelet Activation 100%
  • Integrins 85%
  • Endothelium 80%
  • Leukocytes 72%
  • Blood Platelets 71%
  44 Citations (Scopus)

• Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

  Liaskou, E., Zimmermann, H. W., Li, K-K., Oo, Y. H., Suresh, S., Stamataki, Z., Qureshi, O., Lalor, P. F., Shaw, J., Syn, W., Curbishley, S. M. & Adams, D. H., 7 Jan 2013, In: Hepatology. 57, 1, p. 385-98 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Liver Diseases 100%
  • Monocytes 98%
  • Liver 40%
  • Chemokine CCL1 24%
  • Wound Healing 23%
  139 Citations (Scopus)

• Mucosal immunity in liver autoimmunity: A comprehensive review

  Trivedi, P. J. & Adams, D. H., 24 Jul 2013, In: Journal of Autoimmunity.

  Research output: Contribution to journal › Article › peer-review

  • Sclerosing Cholangitis 100%
  • Mucosal Immunity 98%
  • Autoimmunity 76%
  • Autoimmune Hepatitis 74%
  • Biliary Liver Cirrhosis 70%
  73 Citations (Scopus)

• Primary sclerosing cholangitis

  Hirschfield, G. M., Karlsen, T. H., Lindor, K. D. & Adams, D. H., 27 Jun 2013, In: Lancet.

  Research output: Contribution to journal › Article › peer-review

  • Sclerosing Cholangitis 100%
  • Inflammatory Bowel Diseases 55%
  • Cholangitis 23%
  • Biliary Liver Cirrhosis 23%
  • End Stage Liver Disease 23%
  319 Citations (Scopus)

• The regulation of T-cell recruitment to the human liver during acute liver failure

  Tuncer, C., Oo, Y. H., Murphy, N., Adams, D. H. & Lalor, P. F., 25 Apr 2013, (E-pub ahead of print) In: Liver International. 33, 6, p. 852-863

  Research output: Contribution to journal › Article › peer-review

  • Acute Liver Failure 100%
  • Lymphocytes 59%
  • human AOC3 protein 53%
  • Hepatitis 53%
  • T-Lymphocytes 52%
  17 Citations (Scopus)
• 2012

  CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

  Oo, Y. H., Banz, V., Kavanagh, D., Liaskou, E., Withers, D. R., Humphreys, E., Reynolds, G. M., Lee-Turner, L., Kalia, N., Hubscher, S. G., Klenerman, P., Eksteen, B. & Adams, D. H., Nov 2012, In: Journal of Hepatology. 57, 5, p. 1044-1051 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Th17 Cells 100%
  • Liver 62%
  • Interleukin-17 38%
  • Bile Ducts 36%
  • Helper-Inducer T-Lymphocytes 24%
  115 Citations (Scopus)

  268 Downloads (Pure)

• Regulatory T cells and autoimmune hepatitis: Defective cells or a hostile environment?

  Oo, Y. H. & Adams, D., Jul 2012, In: Journal of Hepatology. 57, 1, p. 6-8

  Research output: Contribution to journal › Article

  Open Access
  24 Citations (Scopus)
• 2011

  Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T Cells across human hepatic sinusoidal endothelium

  Shetty, S., Weston, C., Oo, Y. H., Westerlund, N., Stamataki, Z., Youster, J., Hubscher, S., Salmi, M., Jalkanen, S., Lalor, P. & Adams, D., 1 Apr 2011, In: Journal of Immunology. 186, 7, p. 4147-4155 9 p.

  Research output: Contribution to journal › Article

  • Portal Hypertension 100%
  • Regulatory T-Lymphocytes 89%
  • Endothelium 80%
  • Blood Vessels 53%
  • Liver 46%
  93 Citations (Scopus)

• Hepatic consequences of vascular adhesion protein-1 expression.

  Weston, C. & Adams, D., 22 Apr 2011, In: Journal of Neural Transmission.

  Research output: Contribution to journal › Article

  • Blood Vessels 100%
  • Liver 87%
  • Antigens 80%
  • Leukocytes 67%
  • Proteins 62%
  17 Citations (Scopus)

• Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.

  Liaskou, E., Karikoski, M., Reynolds, GM., Lalor, P., Weston, C., Pullen, N., Salmi, M., Jalkanen, S. & Adams, D., 1 Feb 2011, In: Hepatology. 53, 2, p. 661-672 12 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • mouse semicarbazide-sensitive amine oxidase-vascular adhesion protein-1 100%
  • human AOC3 protein 85%
  • Cell Adhesion Molecule-1 63%
  • Amines 47%
  • Oxidoreductases 41%
  72 Citations (Scopus)

  150 Downloads (Pure)
• 2010

  CX(3)CR1 and Vascular Adhesion Protein-1-Dependent Recruitment of CD16(+) Monocytes Across Human Liver Sinusoidal Endothelium

  Aspinall, AI., Curbishley, S., Lalor, P., Weston, C., Blahova, M., Liaskou, E., Adams, RM., Holt, A. & Adams, D., 1 Jun 2010, In: Hepatology. 51, 6, p. 2030-2039 10 p.

  Research output: Contribution to journal › Article › peer-review

  • CX3C Chemokine Receptor 1 100%
  • Endothelium 53%
  • Monocytes 49%
  • Blood Vessels 35%
  • Liver 30%
  66 Citations (Scopus)

  9 Downloads (Pure)

• Mechanisms of Immune-Mediated Liver Injury

  Adams, D., Ju, C., Ramaiah, SK., Uetrecht, J. & Jaeschke, H., 13 Jan 2010, In: Toxicological Sciences.

  Research output: Contribution to journal › Article

  • Chemical and Drug Induced Liver Injury 100%
  • Liver 65%
  • Wounds and Injuries 61%
  • Innate Immunity 46%
  • Neutrophil Activation 31%
  204 Citations (Scopus)
• 2009

  Adhesion of human haematopoietic (CD34(+)) stem cells to. human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4

  Crosby, H., Lalor, P., Ross, EJ., Newsome, P. & Adams, D., 1 Oct 2009, In: Journal of Hepatology. 51, 4, p. 734-749 16 p.

  Research output: Contribution to journal › Article

  • Hematopoietic Stem Cells 100%
  • Integrins 95%
  • Integrin beta Chains 54%
  • Liver 52%
  • Vascular Cell Adhesion Molecule-1 43%
  17 Citations (Scopus)

• A Phase II Study of Adoptive Immunotherapy Using Dendritic Cells Pulsed with Tumor Lysate in Patients with Hepatocellular Carcinoma

  Palmer, D., Midgley, RS., Mirza, N., Torr, E., Ahmed, F., Steele, J., Steven, N., Kerr, DJ., Young, L. & Adams, D., 1 Jan 2009, In: Hepatology. 49, 1, p. 124-132 9 p.

  Research output: Contribution to journal › Article

  • Adoptive Immunotherapy 100%
  • Dendritic Cells 67%
  • Hepatocellular Carcinoma 61%
  • Neoplasms 24%
  • Vaccination 24%
  185 Citations (Scopus)

• Chemokines in the immunopathogenesis of hepatitis C infection.

  Heydtmann, M. & Adams, D., 1 Feb 2009, In: Hepatology. 49, 2, p. 676-88 13 p.

  Research output: Contribution to journal › Article

  • Hepatitis C 100%
  • Chemokines 91%
  • Hepacivirus 90%
  • Virus Diseases 47%
  • Infections 46%
  113 Citations (Scopus)

• Haematopoietic stem cell recruitment to injured murine liver sinusoids depends on alpha(4)beta(1) integrin/VCAM-1 interactions

  Kavanagh, D., Durant, LE., Crosby, H., Lalor, P., Frampton, J., Adams, D. & Kalia, N., 1 Jan 2009, In: Gut. 59, 1, p. 79-87 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin alpha4beta1 100%
  • Vascular Cell Adhesion Molecule-1 81%
  • Hematopoietic Stem Cells 69%
  • Capillaries 68%
  • Liver 36%
  20 Citations (Scopus)
• 2008

  CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.

  Miles, A., Liaskou, E., Eksteen, J., Lalor, P. & Adams, D., 1 May 2008, In: American journal of physiology. Gastrointestinal and liver physiology. 294, 5, p. G1257-67

  Research output: Contribution to journal › Article › peer-review

  • integrin beta7 100%
  • Integrin alpha4 95%
  • Cell Adhesion Molecule-1 68%
  • Chemokines 45%
  • Lymphocytes 33%
  48 Citations (Scopus)

• Lymphocyte recruitment to the liver: molecular insights into the pathogenesis of liver injury and hepatitis.

  Shetty, S., Lalor, P. & Adams, D., 30 Dec 2008, In: Toxicology. 254, 3, p. 136-46 11 p.

  Research output: Contribution to journal › Article

  • Liver Effect 100%
  • Hepatitis 49%
  • Lymphocytes 36%
  • Flow 33%
  • Liver 26%
  41 Citations (Scopus)
• 2007

  Activation of vascular adhesion protein-1 on liver endothelium results in an NFkB-dependent increase in lymphocyte adhesion

  Lalor, P., Jun Sun, P., Weston, C., Martin, A., Wakelam, M. & Adams, D., 1 Feb 2007, In: Hepatology. 45, p. 465-474 10 p.

  Research output: Contribution to journal › Article

  • Endothelium 100%
  • Lymphocytes 78%
  • Blood Vessels 66%
  • Liver 58%
  • Leukocytes 44%
  82 Citations (Scopus)

• Vascular adhesion protein-1 as a potential therapeutic target in liver disease.

  Lalor, P., Tuncer, C., Weston, C., Martin-Santos, A., Smith, DJ. & Adams, D., 1 Sept 2007, In: Annals of the New York Academy of Sciences. 1110, p. 485-96 12 p.

  Research output: Contribution to journal › Article

  • Protein 100%
  • Adhesion 96%
  • Liver Diseases 70%
  • Therapeutics 64%
  • Blood Vessels 49%
  15 Citations (Scopus)