Investigating the metabolic and epigenetic basis of the immediate and persistent state of systemic immune paresis that occurs following major trauma

Hazeldine, Jon (Principal Investigator)

Inflammation and Ageing

Short title	Investigating the metabolic and epigenetic basis of the immediate and persistent state of systemic immune paresis that occurs following major trauma
Status	Active
Effective start/end date	1/03/23 → 29/02/28

Funding

Medical Research Council

3 Article

Impact of Senescent Cell-Derived Extracellular Vesicles on Innate Immune Cell Function
Chen, Y.-Y., Sullivan, J., Hanley, S., Price, J., Tariq, M., McIlvenna, L. C., Whitham, M., Sharma-Oates, A., Harrison, P., Lord, J. & Hazeldine, J., 23 Oct 2024, (E-pub ahead of print) In: Advanced Biology. 13 p., 2400265.
Research output: Contribution to journal › Article › peer-review

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Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression
Tullie, S., Nicholson, T., Bishop, J., McGee, K., Asiri, A., Sullivan, J., Chen, Y.-Y., Veiga Sardeli, A., Belli, T., Harrison, P., Moiemen, N., Lord, J. & Hazeldine, J., 14 Jun 2024, In: Frontiers in immunology. 15, 22 p., 1416820.
Research output: Contribution to journal › Article › peer-review

Open Access
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The impact of trauma relevant concentrations of prostaglandin E₂ on the anti-microbial activity of the innate immune system
Nicholson, T., Belli, T., Lord, J. & Hazeldine, J., 22 Oct 2024, In: Frontiers in immunology. 15, 26 p., 1401185.
Research output: Contribution to journal › Article › peer-review

Open Access
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