Investigating Hexose-6-Phosphate Dehydrogenase in the Control of Skeletal Muscle Function and Carbohydrate Metabolism

Research output

Research output per year 2009 2013 2020

• 23 Article
• 2 Review article
• 1 Paper

Research output per year

Research output per year

Search results

• 2020

  Induction of the nicotinamide riboside kinase NAD⁺ salvage pathway in a model of sarcoplasmic reticulum dysfunction

  Doig, C. L., Zielinska, A. E., Fletcher, R. S., Oakey, L. A., Elhassan, Y. S., Garten, A., Cartwright, D., Heising, S., Alsheri, A., Watson, D. G., Prehn, C., Adamski, J., Tennant, D. A. & Lavery, G. G., 19 Feb 2020, In: Skeletal Muscle. 10, 1, 13 p., 5.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • nicotinamide riboside kinase 100%
  • galactose-6-phosphate dehydrogenase 57%
  • Sarcoplasmic Reticulum 53%
  • NAD 48%
  • Muscular Diseases 16%
  154 Downloads (Pure)
• 2017

  11β-HSD1 modulates the set-point of brown adipose tissue response to glucocorticoids in male mice

  Doig, C., Fletcher, R., Morgan, S., McCabe, E., Larner, D., Tomlinson, J., Stewart, P., Philp, A. & Lavery, G., 1 Jun 2017, In: Endocrinology. 158, 6, p. 1964-1976

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Brown Adipose Tissue 83%
  • Glucocorticoids 62%
  • Brown Adipocytes 16%
  • Uncoupling Protein 1 8%
  12 Citations (Scopus)

  196 Downloads (Pure)

• Cellular and genetic models of H6PDH and 11β-HSD1 function in skeletal muscle

  Zielinska, A., Fletcher, R., Sherlock, M., Doig, C. & Lavery, G., Jul 2017, In: Cell Biochemistry & Function. 35, 5, p. 269-277

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • galactose-6-phosphate dehydrogenase 100%
  • Hexose 6-Phosphate 98%
  • 11-beta-Hydroxysteroid Dehydrogenases 79%
  • Genetic Models 60%
  • glucose 6-phosphate(transporter) 51%
  1 Citation (Scopus)

  164 Downloads (Pure)
• 2016

  11β-hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

  Hardy, R. S., Doig, C. L., Hussain, Z., O'Leary, M., Morgan, S. A., Pearson, M. J., Naylor, A., Jones, S., Filer, A., Stewart, P. M., Buckley, C. D., Lavery, G. G., Cooper, M. S. & Raza, K., Dec 2016, In: Journal of Pathology. 240, 4, p. 472-483 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Muscles 41%
  • Inflammation 40%
  • Glucocorticoids 28%
  • Skeletal Muscle Fibers 17%
  14 Citations (Scopus)

  140 Downloads (Pure)

• Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism

  Morgan, S., Hassan-Smith, Z., Doig, C., Sherlock, M., Stewart, P. & Lavery, G., 1 Jun 2016, In: Journal of Endocrinology. 229, 3, p. 277-286

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Skeletal Muscle Fibers 76%
  • Glucocorticoids 62%
  • 11-dehydrocorticosterone 50%
  • Proteolysis 36%
  16 Citations (Scopus)

  147 Downloads (Pure)
• 2014

  11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess

  Morgan, S. A., McCabe, E. L., Gathercole, L. L., Hassan-Smith, Z. K., Larner, D. P., Bujalska, I. J., Stewart, P. M., Tomlinson, J. W. & Lavery, G. G., 17 Jun 2014, In: National Academy of Sciences. Proceedings. 111, 24, p. E2482-91

  Research output: Contribution to journal › Article › peer-review

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Glucocorticoids 62%
  • Cushing Syndrome 41%
  • Liver 17%
  • Phenotype 13%
  147 Citations (Scopus)

• 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice

  Penno, C. A., Morgan, S. A., Rose, A. J., Herzig, S., Lavery, G. G. & Odermatt, A., Aug 2014, In: Molecular metabolism. 3, 5, p. 554-64 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Fatty Acid Transport Proteins 100%
  • 11-beta-Hydroxysteroid Dehydrogenases 87%
  • Bile Acids and Salts 62%
  • Glucocorticoid Receptors 47%
  • Homeostasis 44%
  8 Citations (Scopus)

• TNFα-mediated Hsd11b1 binding of NF-κB p65 is associated with suppression of 11β-HSD1 in muscle

  Doig, C. L., Bashir, J., Zielinska, A. E., Cooper, M., Stewart, P. M. & Lavery, G. G., Mar 2014, In: Journal of Endocrinology. 220, 3, p. 389-96 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Mesenchymal Stem Cells 46%
  • Muscles 41%
  • Glucocorticoids 31%
  • 11-dehydrocorticosterone 29%
  7 Citations (Scopus)
• 2013

  11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects

  Gathercole, L. L., Lavery, G. G., Morgan, S. A., Cooper, M., Sinclair, A. J., Tomlinson, J. W. & Stewart, P. M., Aug 2013, In: Endocrine Reviews. 34, 4, p. 525-55 31 p.

  Research output: Contribution to journal › Article › peer-review

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Cortisone reductase deficiency 28%
  • Glucocorticoids 25%
  • Cortisone 16%
  • Intracranial Hypertension 16%
  102 Citations (Scopus)

• 11β-hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

  Tiganescu, A., Tahrani, A. A., Morgan, S. A., Otranto, M., Desmoulière, A., Abrahams, L., Hassan-Smith, Z., Walker, E. A., Rabbitt, E. H., Cooper, M. S., Amrein, K., Lavery, G. G. & Stewart, P. M., 3 Jun 2013, In: Journal of Clinical Investigation. 123, 7, p. 3051-3060

  Research output: Contribution to journal › Article › peer-review

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Skin 37%
  • Glucocorticoids 20%
  • Collagen 17%
  • Wound Healing 13%
  81 Citations (Scopus)

• 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

  Mitić, T., Shave, S., Semjonous, N., Mcnae, I., Cobice, D. F., Lavery, G. G., Webster, S. P., Hadoke, P. W. F., Walker, B. R. & Andrew, R., 1 Jul 2013, In: Biochemical Pharmacology. 86, 1, p. 146-153

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Oxysterols 99%
  • Glucocorticoid 88%
  • Glucocorticoids 62%
  • Pharmacological Metabolism 26%
  21 Citations (Scopus)

  384 Downloads (Pure)

• Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1

  Meyer, A., Vuorinen, A., Zielinska, A. E., Da Cunha, T., Strajhar, P., Lavery, G. G., Schuster, D. & Odermatt, A., 1 May 2013, In: Biochemical Pharmacology. 85, 9, p. 1370-8 9 p.

  Research output: Contribution to journal › Article › peer-review

  • triadimefon 100%
  • Triadimefon 88%
  • 11-beta-Hydroxysteroid Dehydrogenases 77%
  • Triadimenol 46%
  • Rodentia 44%
  9 Citations (Scopus)

• Cell-intrinsic regulation of murine dendritic cell function and survival by pre-receptor amplification of glucocorticoid

  Soulier, A., Blois, S. M., Sivakumaran, S., Fallah-arani, F., Henderson, S., Flutter, B., Rabbitt, E. H., Stewart, P. M., Lavery, G. G., Bennett, C., Curnow, S. J. & Chakraverty, R., 2013, In: Blood.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Formation of threohydrobupropion from bupropion is dependent on 11β-hydroxysteroid dehydrogenase 1

  Meyer, A., Vuorinen, A., Zielinska, A. E., Strajhar, P., Lavery, G. G., Schuster, D. & Odermatt, A., Sept 2013, In: Drug Metabolism and Disposition. 41, 9, p. 1671-8 8 p.

  Research output: Contribution to journal › Article › peer-review

  • hydrobupropion 100%
  • Bupropion 81%
  • 11-beta-Hydroxysteroid Dehydrogenases 71%
  • Prednisone 30%
  • Cortisone 28%
  20 Citations (Scopus)

• Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid

  Penno, C. A., Morgan, S. A., Vuorinen, A., Schuster, D., Lavery, G. G. & Odermatt, A., Oct 2013, In: Journal of Lipid Research. 54, 10, p. 2874-83 10 p.

  Research output: Contribution to journal › Article › peer-review

  • 7-Oxolithocholic Acid 100%
  • 7-ketolithocholic acid 99%
  • 11-beta-Hydroxysteroid Dehydrogenases 65%
  • Bile Acid 17%
  • Bile Acids and Salts 15%
  10 Citations (Scopus)

• Novel H6PDH mutations in two girls with premature adrenarche : 'apparent' and 'true' CRD can be differentiated by urinary steroid profiling

  Lavery, G. G., Idkowiak, J., Sherlock, M., Bujalska, I., Ride, J. P., Saqib, K., Hartmann, M. F., Hughes, B., Wudy, S. A., De Schepper, J., Arlt, W., Krone, N., Shackleton, C. H., Walker, E. A. & Stewart, P. M., 1 Feb 2013, In: European Journal of Endocrinology . 168, 2, p. K19-K26

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cortisone reductase deficiency 100%
  • Adrenarche 77%
  • Steroids 35%
  • Mutation 26%
  • Hyperandrogenism 9%
  34 Citations (Scopus)

  201 Downloads (Pure)

• Regulation of Lipid Metabolism by Glucocorticoids and 11β-HSD1 in Skeletal Muscle

  Morgan, S. A., Gathercole, L. L., Simonet, C., Hassan-Smith, Z. K., Bujalska, I., Guest, P., Abrahams, L., Smith, D. M., Stewart, P. M., Lavery, G. G. & Tomlinson, J. W., 30 Apr 2013, In: Endocrinology. 154, 7, p. 2374-2384 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 11-dehydrocorticosterone 100%
  • 11-beta-Hydroxysteroid Dehydrogenases 85%
  • Lipid Metabolism 56%
  • Glucocorticoids 53%
  • Corticosterone 49%
  24 Citations (Scopus)
• 2012

  Biomarkers of hypothalamic–pituitary–adrenal axis activity in mice lacking 11β-HSD1 and H6PDH

  Abrahams, L., Semjonous, N. M., Guest, P., Zielinska, A., Hughes, B., Lavery, G. G. & Stewart, P. M., 1 Sept 2012, In: Journal of Endocrinology. 214, 3, p. 367-372

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • galactose-6-phosphate dehydrogenase 100%
  • 11-beta-Hydroxysteroid Dehydrogenases 79%
  • Biomarkers 35%
  • Corticosterone 10%
  • 11-dehydrocorticosterone 8%
  9 Citations (Scopus)

  235 Downloads (Pure)

• Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1.

  Lavery, G., Zielinska, A., Gathercole, L., Hughes, B., Semjonous, N., Guest, P., Saqib, K., Sherlock, M., Reynolds, G., Morgan, S., Tomlinson, J., Walker, E., Rabbitt, E. & Stewart, P., 3 May 2012, In: Endocrinology. 153, 7, p. 3236-3248 13 p.

  Research output: Contribution to journal › Article

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Glucocorticoids 46%
  • Liver 35%
  • Corticosterone 27%
  • Cortisone 21%
  50 Citations (Scopus)

• Thymic function is maintained during Salmonella-induced atrophy and recovery

  Ross, E. A., Coughlan, R. E., Flores-Langarica, A., Lax, S., Nicholson, J., Desanti, G. E., Marshall, J. L., Bobat, S., Hitchcock, J., White, A., Jenkinson, W. E., Khan, M., Henderson, I. R., Lavery, G. G., Buckley, C. D., Anderson, G. & Cunningham, A. F., 1 Nov 2012, In: Journal of Immunology. 189, 9, p. 4266-4274 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Salmonella 100%
  • Atrophy 82%
  • T-Lymphocytes 58%
  • Thymocytes 51%
  • Cell Count 35%
  28 Citations (Scopus)

  21 Downloads (Pure)
• 2011

  Cortisone-reductase deficiency associated with heterozygous mutations in 11 beta-hydroxysteroid dehydrogenase type 1

  Lawson, AJ., Walker, E., Lavery, G., Bujalska, I., Hughes, B., Arlt, W., Stewart, P. & Ride, J., 1 Mar 2011, In: National Academy of Sciences. Proceedings. 108, 10, p. 4111-4116 6 p.

  Research output: Contribution to journal › Article

  • Cortisone reductase deficiency 100%
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 71%
  • Mutation 26%
  • Hydrocortisone 17%
  • Coenzymes 12%
  39 Citations (Scopus)

• Hexose-6-Phosphate Dehydrogenase Contributes to Skeletal Muscle Homeostasis Independent of 11 beta-Hydroxysteroid Dehydrogenase Type 1

  Semjonous, N., Sherlock, M., Jeyasuria, P., Parker, KL., Walker, E., Stewart, P. & Lavery, G., 1 Jan 2011, In: Endocrinology. 152, 1, p. 93-102 10 p.

  Research output: Contribution to journal › Article

  • galactose-6-phosphate dehydrogenase 100%
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 81%
  • Skeletal Muscle 43%
  • Homeostasis 39%
  • Glucocorticoids 35%
  28 Citations (Scopus)
• 2009

  11{beta}-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle

  Morgan, S., Sherlock, M., Gathercole, L., Lavery, G., Lenaghan, C., Bujalska, I., Laber, D., Yu, A., Convey, G., Mayers, R., Hegyi, K., Sethi, JK., Stewart, P., Smith, DM. & Tomlinson, J., 12 Aug 2009, In: Diabetes. 58, 11, p. 2506-2515 10 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 100%
  • Glucocorticoids 60%
  • Insulin Resistance 54%
  • Skeletal Muscle 52%
  • Rodentia 27%
  116 Citations (Scopus)

  204 Downloads (Pure)