Interrogating nicotinamide riboside kinase activity as a key determinant of CD4+ T cell metabolism, fate and function

Lavery, Gareth (Co-Investigator)
Dimeloe, Sarah (Principal Investigator)

Short title	Interrogating nicotinamide riboside kinase activity as a key determinant of CD4+ T cell metabolism, fate and function
Status	Finished
Effective start/end date	1/08/21 → 30/09/24

Funding

Medical Research Council

2 Article
1 Review article

Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4⁺ T cells.
Stavrou, V., Ali, M., Gudgeon, N., Bishop, E. L., Fulton-Ward, T., Turley, B., Heising, S., Mohamed, S. H., Hain, S., George, L., Deng, M., McCowan, J., Sheriff, L., Davies, S. P., Marzullo, B., Tennant, D. A., Doig, C. L., Bending, D. A., Roberts, E. W. & Lavery, G. G. & 2 others, Drummond, R. A. & Dimeloe, S., 4 Feb 2026, (E-pub ahead of print) In: Nature Communications.
Research output: Contribution to journal › Article › peer-review

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NAD + metabolism and function in innate and adaptive immune cells
Mann, R., Stavrou, V. & Dimeloe, S., 1 Aug 2025, In: Journal of inflammation (London, England). 22, 1, 9 p., 30.
Research output: Contribution to journal › Review article › peer-review

Open Access
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TNF-α signals through ITK-Akt-mTOR to drive CD4⁺ T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis
Bishop, E. L., Gudgeon, N., Fulton-Ward, T., Stavrou, V., Roberts, J., Boufersaoui, A., Tennant, D. A., Hewison, M., Raza, K. & Dimeloe, S., 23 Apr 2024, In: Science signaling. 17, 833, eadg5678.
Research output: Contribution to journal › Article › peer-review

Open Access
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245 Downloads (Pure)