Hydroxysteroid Dehydrogenase Activity and the Vitamin D Axis in Acute Lung Injury - Mechanistic and Functional Importance

Lavery, Gareth (Co-Investigator)
Lax, Sian (Co-Investigator)
Thickett, David (Principal Investigator)
Mitchell, Tim (Co-Investigator)

6 Article

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2023
Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS
Mahida, R. Y., Lax, S., Bassford, C. R., Scott, A., Parekh, D., Hardy, R. S., Naidu, B., Matthay, M. A., Stewart, P. M., Cooper, M. C., Perkins, G. D. & Thickett, D. R., 27 Apr 2023, In: Frontiers in immunology. 14, 14 p., 1159831.
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Real-time assessment of neutrophil metabolism and oxidative burst using extracellular flux analysis
Grudzinska, F., Jasper, A., Sapey, E., Thickett, D., Mauro, C., Scott, A. & Barlow, J., 25 Apr 2023, In: Frontiers in immunology. 14, 12 p., 1083072.
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2022
CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome
Mahida, R. Y., Price, J., Lugg, S. T., Li, H., Parekh, D., Scott, A., Harrison, P., Matthay, M. A. & Thickett, D. R., 6 Apr 2022, In: American journal of physiology. Lung cellular and molecular physiology. 322, 4, p. L617-L624
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2021

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis
Mahida, R. Y., Scott, A., Parekh, D., Lugg, S. T., Hardy, R. S., Lavery, G. G., Matthay, M. A., Naidu, B., Perkins, G. D. & Thickett, D. R., 9 Sept 2021, In: The European respiratory journal. 58, 3, 2100829.
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Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome
Mahida, R. Y., Scott, A., Parekh, D., Lugg, S. T., Belchamber, K. B. R., Hardy, R. S., Matthay, M. A., Naidu, B. & Thickett, D. R., 29 Sept 2021, In: Frontiers in Medicine. 8, 737859.
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Real-world retrospective observational study exploring the effectiveness and safety of antifibrotics in idiopathic pulmonary fibrosis
Wright, W. A., Crowley, L. E., Parekh, D., Crawshaw, A., Dosanjh, D. P., Nightingale, P. & Thickett, D. R., 26 Mar 2021, In: BMJ Open Respiratory Research. 8, 1, e000782.
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