Hydroxysteroid Dehydrogenase Activity and the Vitamin D Axis in Acute Lung Injury - Mechanistic and Functional Importance

Lavery, Gareth (Co-Investigator)
Lax, Sian (Co-Investigator)
Thickett, David (Principal Investigator)
Mitchell, Tim (Co-Investigator)

Short title	Hydroxysteroid Dehydrogenase Activity and the Vitamin D Axis in Acute Lung Injury - Mechanistic and Functional Importance
Status	Finished
Effective start/end date	1/06/14 → 31/05/17

Funding

Medical Research Council

11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis
Mahida, R. Y., Yuan, Z., Kolluri, K. K., Scott, A., Parekh, D., Hardy, R. S., Matthay, M. A., Perkins, G. D., Janes, S. M. & Thickett, D. R., 5 Jul 2024, In: Frontiers in Bioengineering and Biotechnology. 12, 15 p., 1422761.
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Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS
Mahida, R. Y., Lax, S., Bassford, C. R., Scott, A., Parekh, D., Hardy, R. S., Naidu, B., Matthay, M. A., Stewart, P. M., Cooper, M. C., Perkins, G. D. & Thickett, D. R., 27 Apr 2023, In: Frontiers in immunology. 14, 14 p., 1159831.
Research output: Contribution to journal › Article › peer-review

Open Access
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Real-time assessment of neutrophil metabolism and oxidative burst using extracellular flux analysis
Grudzinska, F., Jasper, A., Sapey, E., Thickett, D., Mauro, C., Scott, A. & Barlow, J., 25 Apr 2023, In: Frontiers in immunology. 14, 12 p., 1083072.
Research output: Contribution to journal › Article › peer-review

Open Access
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154 Downloads (Pure)