Human cellular platforms for studying the regulation and therapeutic application of autophagy

2025

Autophagy is required for the development and functionality of lacrimal gland-like organoids

Kocak, G., Korsgen, M. E., Amores, L. F., Sun, C., Ceylan, M., Ghazwani, A., Kandirici, M., Zatyka, M., Seranova, E., Acharjee, A., Barrett, T., Yuksel, B., Mardinoglu, A., Güven, S. & Sarkar, S., 18 Dec 2025, (E-pub ahead of print) In: Stem Cell Reports.

Research output: Contribution to journal › Article › peer-review

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Autophagy–NAD⁺ axis: emerging insights into neuronal homeostasis and neurodegenerative diseases

Kocak, G., Dimas, M. M., Silva, L. F. S. E., Silva-Amaral, D., Sun, C., Cruddas, S., Barrett, T., Martins-de-Souza, D., Cunha-Neto, E., Brocardo, P. S., Kataura, T., Korolchuk, V. I. & Sarkar, S., 26 Nov 2025, In: Frontiers in Molecular Biosciences. 12, 17 p., 1695486.

Research output: Contribution to journal › Review article › peer-review

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Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

Aubry, L., Barrett, T. & Sarkar, S., Sept 2025, In: Neural Regeneration Research. 20, 9, p. 2587-2588 2 p.

Research output: Contribution to journal › Letter › peer-review

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2024

Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models

Kataura, T., Sedlackova, L., Sun, C., Kocak, G., Wilson, N., Banks, P., Hayat, F., Trushin, S., Trushina, E., Maddocks, O. D. K., Oblong, J. E., Miwa, S., Imoto, M., Saiki, S., Erskine, D., Migaud, M. E., Sarkar, S. & Korolchuk, V. I., 31 May 2024, (E-pub ahead of print) In: Cell death & disease. 15, 5, 13 p., 382.

Research output: Contribution to journal › Article › peer-review

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2023

Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons

Korsgen, M. E., Sun, C., Seranova, E., Zatyka, M., Astuti, D., Kataura, T., Barrett, T., Korolchuk, V. I. & Sarkar, S., 25 Aug 2023, (E-pub ahead of print) In: STAR Protocols. 4, 3, 102529.

Research output: Contribution to journal › Article › peer-review

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Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome

Zatyka, M., Rosenstock, T. R., Sun, C., Palhegyi, A. M., Hughes, G. W., Lara-Reyna, S., Astuti, D., di Maio, A., Sciauvaud, A., Korsgen, M. E., Stanulovic, V., Kocak, G., Rak, M., Pourtoy-Brasselet, S., Winter, K., Varga, T., Jarrige, M., Polvèche, H., Correia, J. & Frickel, E.-M. & 5 others, Hoogenkamp, M., Ward, D. G., Aubry, L., Barrett, T. & Sarkar, S., 9 May 2023, In: Stem Cell Reports. 18, 5, p. 1090-1106 17 p.

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Metabolic function of autophagy is essential for cell survival

Sedlackova, L., Kataura, T., Sarkar, S. & Korolchuk, V. I., 1 Feb 2023, In: Autophagy. 19, 8, p. 2395-2397 3 p.

Research output: Contribution to journal › Comment/debate › peer-review

NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

Sun, C., Seranova, E., Cohen, M. A., Chipara, M., Roberts, J., Astuti, D., Palhegyi, A. M., Acharjee, A., Sedlackova, L., Kataura, T., Otten, E. G., Panda, P. K., Lara-Reyna, S., Korsgen, M. E., Kauffman, K. J., Huerta-Uribe, A., Zatyka, M., Silva, L. F. S. E., Torresi, J. & Zhang, S. & 20 others, Hughes, G. W., Ward, C., Kuechler, E. R., Cartwright, D., Trushin, S., Trushina, E., Sahay, G., Buganim, Y., Lavery, G. G., Gsponer, J., Anderson, D. G., Frickel, E. M., Rosenstock, T. R., Barrett, T., Maddocks, O. D. K., Tennant, D. A., Wang, H., Jaenisch, R., Korolchuk, V. I. & Sarkar, S., 30 May 2023, In: Cell Reports. 42, 5, 26 p., 112372.

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1 Citation (Scopus)

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The autophagy–NAD axis in longevity and disease

Wilson, N., Kataura, T., Korsgen, M. E., Sun, C., Sarkar, S. & Korolchuk, V. I., Sept 2023, In: Trends in Cell Biology. 33, 9, p. 788-802 15 p.

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2022

Analysis of Mitochondrial Dysfunction by Microplate Reader in hiPSC-Derived Neuronal Cell Models of Neurodegenerative Disorders

Rosenstock, T. R., Sun, C., Hughes, G. W., Winter, K. & Sarkar, S., 3 Jul 2022, Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols. Turksen, K. (ed.). 1st ed. Humana Press, p. 1-21 21 p. (Methods in Molecular Biology; vol. 2549).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Autophagy Dysfunction as a Phenotypic Readout in hiPSC-Derived Neuronal Cell Models of Neurodegenerative Diseases

Sun, C., Rosenstock, T. R., Cohen, M. A. & Sarkar, S., 3 Jul 2022, Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols. Turksen, K. (ed.). 1st ed. Humana Press, p. 103-136 34 p. (Methods in Molecular Biology; vol. 2549).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Autophagy promotes cell survival by maintaining NAD levels

Kataura, T., Sedlackova, L., Otten, E. G., Kumari, R., Shapira, D., Scialo, F., Stefanatos, R., Ishikawa, K.-I., Kelly, G., Seranova, E., Sun, C., Maetzel, D., Kenneth, N., Trushin, S., Zhang, T., Trushina, E., Bascom, C. C., Tasseff, R., Isfort, R. J. & Oblong, J. E. & 11 others, Miwa, S., Lazarou, M., Jaenisch, R., Imoto, M., Saiki, S., Papamichos-Chronakis, M., Manjithaya, R., Maddocks, O. D. K., Sanz, A., Sarkar, S. & Korolchuk, V. I., 21 Nov 2022, In: Developmental Cell. 57, 22, p. 2584-2598.e1-e11 27 p.

Research output: Contribution to journal › Article › peer-review

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2021

Oxygen Consumption Evaluation: An Important Indicator of Metabolic State, Cellular Function, and Cell Fate Along Neural Deregulation

Brito, M. D., Souza e Silva, L. F., Siena, A., Chipara, M., Sarkar, S. & Rosenstock, T. R., 10 Jan 2021, Toxicity Assessment: Methods and Protocols. Palmeira, C. M. M., Palma de Oliveira, D. & Dorta, D. J. (eds.). 1st ed. Humana Press, p. 207-230 24 p. (Methods in Molecular Biology; vol. 2240).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block

Sharma, V., Makhdoomi, M., Singh, L., Kumar, P., Khan, N., Singh, S., Verma, H. N., Luthra, K., Sarkar, S. & Kumar, D., Feb 2021, In: Autophagy. 17, 2, p. 476-495 20 p.

Research output: Contribution to journal › Article › peer-review

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2020

Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy

Seranova, E., Palhegyi, A. M., Verma, S., Dimova, S., Lasry, R., Naama, M., Sun, C., Barrett, T., Rosenstock, T. R., Kumar, D., Cohen, M. A., Buganim, Y. & Sarkar, S., 3 Apr 2020, In: Journal of Molecular Biology. 432, 8, p. 2754-2798 45 p.

Research output: Contribution to journal › Review article › peer-review

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4 Citations (Scopus)

466 Downloads (Pure)

2019

Biomedical Implications of Autophagy in Macromolecule Storage Disorders

Palhegyi, A. M., Seranova, E., Dimova, S., Hoque, S. & Sarkar, S., 6 Sept 2019, In: Frontiers in cell and developmental biology. 7, 179.

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7 Citations (Scopus)

302 Downloads (Pure)

Human cellular platforms for studying the regulation and therapeutic application of autophagy

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