How does systemic flagellin immunization induce mucosal lgA?

Research output

Research output per year 2014 2015 2017 2020

• 17 Article
• 1 Editorial

Research output per year

Research output per year

Search results

• 2020

  Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface

  Domínguez-Medina, C. C., Pérez-Toledo, M., Schager, A. E., Marshall, J. L., Cook, C. N., Bobat, S., Hwang, H., Chun, B. J., Logan, E., Bryant, J. A., Channell, W. M., Morris, F. C., Jossi, S. E., Alshayea, A., Rossiter, A. E., Barrow, P. A., Horsnell, W. G., MacLennan, C. A., Henderson, I. R., Lakey, J. H., & 4 othersGumbart, J. C., López-Macías, C., Bavro, V. N. & Cunningham, A. F., 12 Feb 2020, In: Nature Communications. 11, 851.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • salmonella 100%
  • O Antigens 89%
  • antigens 82%
  • antibodies 76%
  • Lipopolysaccharide 71%
  11 Citations (Scopus)

  162 Downloads (Pure)
• 2018

  CD103⁺CD11b⁺ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

  Flores-Langarica, A., Müller Luda, K., Persson, E. K., Cook, C. N., Bobat, S., Marshall, J. L., Dahlgren, M. W., Hägerbrand, K., Toellner, K. M., Goodall, M. D., Withers, D., Henderson, I. R., Johansson Lindbom, B., Cunningham, A. & Agace, W. W., May 2018, In: Mucosal immunology. 11, 3, p. 681-692 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flagellin 100%
  • Plasma Cells 73%
  • Antibody Formation 66%
  • Dendritic Cells 65%
  • Bone Marrow 53%
  8 Citations (Scopus)

  183 Downloads (Pure)

• Intestinal CD103CD11b cDC2 Conventional Dendritic Cells Are Required for Primary CD4 T and B Cell Responses to Soluble Flagellin

  Flores-Langarica, A., Cook, C., Müller Luda, K., Persson, E. K., Marshall, J. L., Beristain-Covarrubias, N., Yam-Puc, J. C., Dahlgren, M., Persson, J. J., Uematsu, S., Akira, S., Henderson, I. R., Lindbom, B. J., Agace, W. & Cunningham, A. F., 17 Oct 2018, In: Frontiers in immunology. 9, 2409.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flagellin 100%
  • Dendritic Cells 65%
  • Mucosal Immunity 60%
  • B-Lymphocytes 56%
  • T-Lymphocytes 45%
  13 Citations (Scopus)

  173 Downloads (Pure)
• 2017

  Antigen localization influences the magnitude and kinetics of the endogenous adaptive immune response to recombinant Salmonella vaccines

  Sevastsyanovich, Y. R., Withers, D. R., Marriott, C. L., Morris, F. C., Wells, T. J., Browning, D. F., Beriotto, I., Ross, E., Ali, H. O., Wardius, C. A., Cunningham, A. F., Henderson, I. R. & Rossiter, A. E., 17 Nov 2017, In: Infection and Immunity. 85, 12 p., e00593-17.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Salmonella Vaccines 100%
  • Synthetic Vaccines 77%
  • adaptive immunity 74%
  • Adaptive Immunity 63%
  • Salmonella 54%
  5 Citations (Scopus)

  104 Downloads (Pure)

• IgG1 is required for optimal protection after immunization with the purified porin OmpD from Salmonella typhimurium

  Zhang, Y., Dominguez-Medina, C., Cumley, N. J., Heath, J. N., Essex, S. J., Bobat, S., Schager, A., Goodall, M., Kracker, S., Buckley, C. D., May, R. C., Kingsley, R. A., MacLennan, C. A., López-Macías, C., Cunningham, A. F. & Toellner, K-M., 15 Dec 2017, In: Journal of Immunology. 199, 12, p. 4103-4109 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Porins 100%
  • Salmonella typhimurium 88%
  • Immunization 64%
  • Immunoglobulin G 58%
  • Helminth Proteins 14%
  13 Citations (Scopus)

  156 Downloads (Pure)

• Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1

  Newman, R., Ahlfors, H., Saveliev, A., Galloway, A., Hodson, D. J., Williams, R., Besra, G. S., Cook, C. N., Cunningham, A. F., Bell, S. E. & Turner, M., Jun 2017, In: Nature Immunology. 18, p. 683–693

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • RNA-Binding Proteins 100%
  • AU Rich Elements 66%
  • B-Lymphocytes 66%
  • Maintenance 60%
  • RNA Stability 47%
  23 Citations (Scopus)

  360 Downloads (Pure)

• Salmonella Typhi Porins OmpC and OmpF Are Potent Adjuvants for T-Dependent and T-Independent Antigens

  Pérez-Toledo, M., Valero-Pacheco, N., Pastelin-Palacios, R., Gil-Cruz, C., Perez-Shibayama, C., Moreno-Eutimio, M. A., Becker, I., Pérez-Tapia, S. M., Arriaga-Pizano, L., Cunningham, A. F., Isibasi, A., Bonifaz, L. C. & López-Macías, C., 9 Mar 2017, In: Frontiers in immunology. 8, p. 230

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T Independent Antigens 100%
  • Porins 87%
  • Salmonella typhi 87%
  • Immunoglobulin Class Switching 35%
  • Immunoglobulin Isotypes 29%
  15 Citations (Scopus)

• The influence of conjugation variables on the design and immunogenicity of a glycoconjugate vaccine against Salmonella Typhi

  Arcuri, M., Di Benedetto, R., Cunningham, A., Saul, A., MavLennan, C. A. & Micoli, F., 29 Dec 2017, In: PLoS ONE.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Salmonella typhi 100%
  • Glycoconjugates 98%
  • Salmonella Typhi 97%
  • glycoconjugates 94%
  • immunogenicity 91%
  14 Citations (Scopus)

  350 Downloads (Pure)

• The Use of Plasmapheresis in Bronchiectasis Patients with Pseudomonas aeruginosa Infection and Inhibitory Antibodies

  Wells, T., Davison, J., Sheehan, E., Kanagasundaram, S., Spickett, G., MacLennan, C., Stockley, R., Cunningham, A., Henderson, I. & De Soyza, A., 1 Apr 2017, In: American Journal of Respiratory and Critical Care Medicine. 195, 7, p. 955-958 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudomonas Infections 100%
  • Plasmapheresis 97%
  • Bronchiectasis 96%
  • Antibodies 44%
  • Immunoglobulin G 30%
  5 Citations (Scopus)

  353 Downloads (Pure)
• 2016

  Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen

  Hart, P. J., O'Shaughnessy, C. M., Siggins, M. K., Bobat, S., Kingsley, R. A., Goulding, D. A., Crump, J. A., Reyburn, H., Micoli, F., Dougan, G., Cunningham, A. F. & MacLennan, C. A., 7 Jan 2016, In: PLoS ONE. 11, 1, e0145945.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Salmonella typhi 100%
  • Salmonella Typhi 97%
  • Lipopolysaccharide 84%
  • lipopolysaccharides 73%
  • Lipopolysaccharides 65%
  24 Citations (Scopus)

  168 Downloads (Pure)
• 2015

  Dominant suppression of inflammation via targeted mutation of the mRNA destabilizing protein tristetraprolin

  Ross, E. A., Smallie, T., Ding, Q., O'neil, J. D., Cunliffe, H. E., Tang, T., Rosner, D. R., Klevernic, I., Morrice, N. A., Monaco, C., Cunningham, A. F., Buckley, C. D., Saklatvala, J., Dean, J. L. & Clark, A. R., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 265-276

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Inflammation 35%
  • Messenger RNA 34%
  • Mutation 34%
  • Salmonella typhimurium 14%
  49 Citations (Scopus)

  182 Downloads (Pure)

• Homeostatic regulation of T cell trafficking by a B cell derived peptide is impaired in autoimmune and chronic inflammatory disease

  Rainger, E., Chimen, M., McGettrick, H., Kuravi, S., Apta, B., Yates, C., Kennedy, A., Odedra, A., Harrison, M., Martin, A., Barone, F., Nayar, S., Hitchcock, J., Cunningham, A., Raza, K., Filer, A., Copland, DA., Dick, A., Robinson, J., Kalia, N., & 5 othersWalker, L., Buckley, C., Nash, G., Narendran, P. & Alassiri, M., 15 May 2015, In: Nature Medicine. 21, 5, p. 467-475 9 p., 3842.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adiponectin 100%
  • B-Lymphocytes 42%
  • Chronic Disease 40%
  • Peptides 35%
  • T-Lymphocytes 34%
  55 Citations (Scopus)

  274 Downloads (Pure)

• Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

  Hitchcock, J. R., Cook, C. N., Bobat, S., Ross, E. A., Flores-Langarica, A., Lowe, K. L., Khan, M., Dominguez Medina, C., Lax, S., Carvalho-Gaspar, M., Hubscher, S., Rainger, G., Cobbold, M., Buckley, C. D., Mitchell, T. J., Mitchell, A., Jones, N., Van Rooijen, N., Kirchhofer, D., Henderson, I. R., & 3 othersAdams, D. H., Watson, S. P. & Cunningham, A. F., 16 Nov 2015, In: Journal of Clinical Investigation. 125, 12, p. 4429–4446

  Research output: Contribution to journal › Article › peer-review

  • C-Type Lectins 100%
  • Salmonella Infections 92%
  • Blood Platelets 57%
  • Thrombosis 57%
  • Inflammation 43%
  95 Citations (Scopus)

  102 Downloads (Pure)

• Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production

  Flores-langarica, A., Bobat, S., Marshall, J. L., Yam-puc, J. C., Cook, C. N., Serre, K., Kingsley, R. A., Flores-romo, L., Uematsu, S., Akira, S., Henderson, I. R., Toellner, K. M. & Cunningham, A. F., 7 Aug 2015, In: European Journal of Immunology. 45, 8, p. 2299-2311

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flagellin 100%
  • Salmonella typhimurium 84%
  • Salmonella 77%
  • Dendritic Cells 65%
  • Cytokines 45%
  13 Citations (Scopus)

  209 Downloads (Pure)

• The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection

  Darby, M., Schnoeller, C., Vira, A., Culley, F. J., Culley, F., Bobat, S., Logan, E., Kirstein, F., Wess, J., Cunningham, A. F., Brombacher, F., Selkirk, M. E. & Horsnell, W. G. C., 28 Jan 2015, In: PLoS pathogens. 11, 1, e1004636.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Muscarinic M3 Receptors 100%
  • helminthiasis 87%
  • muscarine receptors 87%
  • Helminths 81%
  • adaptive immunity 80%
  26 Citations (Scopus)

  126 Downloads (Pure)

• The RNA-binding protein HuR is essential for the B cell antibody response

  Diaz-Muñoz, M. D., Bell, S. E., Fairfax, K., Monzon-Casanova, E., Cunningham, A. F., Gonzalez-Porta, M., Andrews, S. R., Bunik, V. I., Zarnack, K., Curk, T., Heggermont, W. A., Heymans, S., Gibson, G. E., Kontoyiannis, D. L., Ule, J. & Turner, M., Apr 2015, In: Nature Immunology. 16, p. 415-25 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • RNA-Binding Proteins 100%
  • Antibody Formation 77%
  • B-Lymphocytes 66%
  • dihydrolipoamide succinyltransferase 41%
  • Ketoglutarate Dehydrogenase Complex 33%
  74 Citations (Scopus)

  325 Downloads (Pure)
• 2014

  MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus

  Reynolds, L. A., Harcus, Y., Smith, K. A., Webb, L. M., Hewitson, J. P., Ross, E. A., Brown, S., Uematsu, S., Akira, S., Gray, D., Gray, M., MacDonald, A. S., Cunningham, A. F. & Maizels, R. M., 15 Sept 2014, In: Journal of Immunology. 193, 6, p. 2984-93 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nematospiroides dubius 100%
  • Helminths 72%
  • Parasites 49%
  • Immunity 48%
  • Granuloma 45%
  16 Citations (Scopus)