Finding therapeutic targets in FLT3-ITD AML using a systems biology approach

Cockerill, Peter (Co-Investigator)
Bonifer, Conny (Principal Investigator)

Cancer and Genomic Sciences

Short title	Finding therapeutic targets in FLT3-ITD AML using a systems biology approach
Status	Finished
Effective start/end date	1/09/19 → 31/12/23

Funding

Medical Research Council

8 Article
3 Review article
1 Letter

A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression
Almaghrabi, R., Alyahyawi, Y., Keane, P., Mian, S. A., Habel, K., Atkinson, A., Ward, C., Bayley, R., Sargas, C., Menendez, P., Murphy, G. J., Sobahy, T., Baghdadi, M. A., Flemban, A. F., Kabrah, S. M., Torres-Ruiz, R., Papapetrou, E. P., Akerman, I., Raghavan, M. & Barragan, E. & 3 others, Bonnet, D., Bonifer, C. & Garcia, P., 1 Jul 2025, In: Nature Communications. 16, 1, 22 p., 5489.
Research output: Contribution to journal › Article › peer-review

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Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification
Maytum, A., Edginton-White, B., Keane, P., Cockerill, P. N., Cazier, J.-B. & Bonifer, C., Feb 2024, In: Life Science Alliance. 7, 2, 15 p., e202302363.
Research output: Contribution to journal › Article › peer-review

Open Access
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Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis
Potluri, S., Kellaway, S. G., Coleman, D. J. L., Keane, P., Imperato, M. R., Assi, S. A., Cockerill, P. N. & Bonifer, C., Feb 2024, In: Leukemia. 38, 2, p. 403-407 5 p.
Research output: Contribution to journal › Letter › peer-review

Open Access
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63 Downloads (Pure)