Epstein-Barr Virus Infections of B Lymphocytes and the Pathogenesis of Virus-Associated Lymphomas

Research output

Research output per year 2009 2011 2012 2018

• 16 Article

Research output per year

Research output per year

Search results

• 2018

  Proteome-wide analysis of CD8+ T cell responses to EBV reveals differences between primary and persistent infection

  Forrest, C., Hislop, A. D., Rickinson, A. B. & Zuo, J., 24 Sept 2018, In: PLoS pathogens. 14, 9, 32 p., e1007110.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human gammaherpesvirus 4 100%
  • Proteome 77%
  • Human Herpesvirus 4 74%
  • proteome 72%
  • T-lymphocytes 68%
  6 Citations (Scopus)

  160 Downloads (Pure)
• 2017

  Cytomegalovirus-specific T cells restricted by HLA-Cw*0702 increase markedly with age and dominate the CD8+ T-Cell repertoire in older people

  Hosie, L., Pachnio, A., Zuo, J., Pearce, H., Riddell, S. & Moss, P., 11 Dec 2017, In: Frontiers in immunology. 8, 1776.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytomegalovirus 100%
  • HLA-C Antigens 63%
  • T-Lymphocytes 62%
  • Peptides 35%
  • HLA-B Antigens 28%
  20 Citations (Scopus)

  180 Downloads (Pure)
• 2014

  Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

  Kelly, G. L., Grabow, S., Glaser, S. P., Fitzsimmons, L., Aubrey, B. J., Okamoto, T., Valente, L. J., Robati, M., Tai, L., Fairlie, W. D., Lee, E. F., Lindstrom, M. S., Wiman, K. G., Huang, D. C. S., Bouillet, P., Rowe, M., Rickinson, A. B., Herold, M. J. & Strasser, A., 1 Jan 2014, In: Genes & Development. 28, 1, p. 58-70 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lymphoma 100%
  • Mutation 67%
  • Neoplasms 38%
  • Alleles 35%
  • Burkitt Lymphoma 28%
  113 Citations (Scopus)

  384 Downloads (Pure)
• 2012

  Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

  Schmitz, R., Young, R. M., Ceribelli, M., Jhavar, S., Xiao, W., Zhang, M., Wright, G., Shaffer, A. L., Hodson, D. J., Buras, E., Liu, X., Powell, J., Yang, Y., Xu, W., Zhao, H., Kohlhammer, H., Rosenwald, A., Kluin, P., Müller-Hermelink, H. K., Ott, G., & 22 othersGascoyne, R. D., Connors, J. M., Rimsza, L. M., Campo, E., Jaffe, E. S., Delabie, J., Smeland, E. B., Ogwang, M. D., Reynolds, S. J., Fisher, R. I., Braziel, R. M., Tubbs, R. R., Cook, J. R., Weisenburger, D. D., Chan, W. C., Pittaluga, S., Wilson, W., Waldmann, T. A., Rowe, M., Mbulaiteye, S. M., Rickinson, A. B. & Staudt, L. M., 4 Oct 2012, In: Nature. 490, 7418, p. 116-20 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Burkitt Lymphoma 100%
  • Genomics 83%
  • B-Lymphocytes 14%
  • Cyclin D3 13%
  • Therapeutics 13%
  548 Citations (Scopus)

  624 Downloads (Pure)

• Epstein-Barr virus and the pathogenesis of T and NK lymphoma: a mystery unsolved

  George, L. C., Rowe, M. & Fox, C. P., 2012, In: Current Hematologic Malignancy Reports . 7, 4, p. 276-84 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Herpesvirus 4 100%
  • Lymphoma 83%
  • Cercopithecine Herpesvirus 1 34%
  • Viral Genes 29%
  • Neoplasms 24%
  23 Citations (Scopus)

• Epstein-barr virus infection of naïve B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology.

  Heath, E., Begue-Pastor, N., Chaganti, S., Croom-Carter, D., Shannon-Lowe, C., Kube, D., Feederle, R., Delecluse, HJ., Rickinson, A. & Bell, A., 1 May 2012, In: PLoS pathogens. 8, 5, p. e1002697

  Research output: Contribution to journal › Article

  Open Access

  • Human gammaherpesvirus 4 100%
  • Epstein-Barr Virus Infections 89%
  • B-lymphocytes 73%
  • immunoglobulins 72%
  • Immunoglobulins 65%
  45 Citations (Scopus)

• Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

  Palendira, U., Low, C., Bell, A. I., Ma, C. S., Abbott, R. J. M., Phan, T. G., Riminton, D. S., Choo, S., Smart, J. M., Lougaris, V., Giliani, S., Buckley, R. H., Grimbacher, B., Alvaro, F., Klion, A. D., Nichols, K. E., Adelstein, S., Rickinson, A. B. & Tangye, S. G., 2012, In: The Journal of Experimental Medicine. 209, 5, p. 913-24 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Signaling Lymphocytic Activation Molecule Associated Protein 100%
  • Lymphoproliferative Disorders 65%
  • Human Herpesvirus 4 55%
  • T-Lymphocytes 34%
  • Epstein-Barr Virus Infections 33%
  44 Citations (Scopus)

• Revisiting the Effect of Acute P. falciparum Malaria on Epstein-Barr Virus: Host Balance in the Setting of Reduced Malaria Endemicity

  Jayasooriya, S., Hislop, A., Peng, Y., Croom-carter, D., Jankey, Y., Bell, A., Dong, T., Rowland-Jones, S., Rickinson, A., Walther, M. & Whittle, H., 1 Feb 2012, In: PLoS ONE. 7, 2, p. e31142

  Research output: Contribution to journal › Article

  Open Access

  • falciparum malaria 100%
  • Human gammaherpesvirus 4 81%
  • Falciparum Malaria 71%
  • malaria 62%
  • Human Herpesvirus 4 60%
  8 Citations (Scopus)
• 2011

  Downregulation of BLIMP1-alpha by the EBV oncogene, LMP1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B cell lymphomas.

  Vrzalikova, K., Vockerodt, M., Leonard, S., Bell, A., Wei, W., Schrader, A., Wright, KL., Kube, D., Rowe, M., Woodman, C. & Murray, P., 16 Mar 2011, In: Blood. 117, 22, p. 5907-5917 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Epstein-Barr virus EBV-associated membrane antigen 100%
  • B-Cell Lymphoma 67%
  • Plasma Cells 65%
  • Human Herpesvirus 4 65%
  • Oncogenes 62%
  67 Citations (Scopus)

• Epstein-Barr virus BamHI W repeat number limits EBNA2/EBNA-LP co-expression in newly-infected B-cells and the efficiency of B-cell transformation: a rationale for the multiple W repeats in wild-type virus strains.

  Tierney, R., Kao, KY., Nagra, J. & Rickinson, A., 28 Sept 2011, In: Journal of virology.

  Research output: Contribution to journal › Article

  • Human gammaherpesvirus 4 100%
  • Human Herpesvirus 4 74%
  • B-lymphocytes 73%
  • B-Lymphocytes 57%
  • Viruses 49%
  35 Citations (Scopus)

• Epstein-Barr Virus Infection of Polarized Epithelial Cells via the Basolateral Surface by Memory B Cell-Mediated Transfer Infection.

  Shannon-Lowe, C. & Rowe, M., 1 May 2011, In: PLoS pathogens. 7, 5, p. e1001338

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human gammaherpesvirus 4 100%
  • Epstein-Barr Virus Infections 89%
  • B-lymphocytes 73%
  • epithelial cells 64%
  • Human Herpesvirus 4 59%
  77 Citations (Scopus)

• Epstein-Barr virus latent gene sequences as geographical markers of viral origin: unique EBNA3 gene signatures identify Japanese viruses as distinct members of the Asian virus family.

  Sawada, A., Croom-Carter, D., Kondo, O., Yasui, M., Koyama-Sato, M., Inoue, M., Kawa, K., Rickinson, A. & Tierney, R., 1 May 2011, In: Journal of General Virology. 92, Pt 5, p. 1032-43 12 p.

  Research output: Contribution to journal › Article

  • Human Herpesvirus 4 100%
  • Viruses 67%
  • Biomarkers 65%
  • Genes 40%
  • Natural Killer Cells 35%
  14 Citations (Scopus)
• 2010

  Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adults Characterized by High Viral Genome Load within Circulating Natural Killer Cells

  Fox, C., Shannon-Lowe, C., Gothard, P., Kishore, B., Neilson, J., O'Connor, N. & Rowe, M., 1 Jul 2010, In: Clinical Infectious Diseases. 51, 1, p. 66-69 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Hemophagocytic Lymphohistiocytosis 100%
  • Viral Genome 86%
  • Human Herpesvirus 4 75%
  • Viral Load 73%
  • Natural Killer Cells 70%
  45 Citations (Scopus)

• Quantitative studies of Epstein-Barr virus-encoded miRNAs provide novel insights into their regulation.

  Amoroso, R., Fitzsimmons, L., Thomas, W., Kelly, G., Rowe, M. & Bell, A., 10 Nov 2010, In: Journal of virology. 85, 2, p. 996-1010 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Human gammaherpesvirus 4 100%
  • microRNA 75%
  • Human Herpesvirus 4 74%
  • MicroRNAs 62%
  • transcription (genetics) 9%
  79 Citations (Scopus)
• 2009

  Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology

  Rowe, M., Kelly, G., Bell, A. & Rickinson, A., 1 Dec 2009, In: Seminars in Cancer Biology. 19, 6, p. 377-88 12 p.

  Research output: Contribution to journal › Article

  • Burkitt Lymphoma 100%
  • Human Herpesvirus 4 82%
  • Viruses 22%
  • Neoplasms 16%
  67 Citations (Scopus)

• Epstein-Barr virus colonization of tonsillar and peripheral blood B-cell subsets in primary infection and persistence.

  Chaganti, S., Heath, E., Bergler, W., Kuo, M., Buettner, M., Niedobitek, G., Rickinson, A. & Bell, A., 18 Jun 2009, In: Blood. 113, 25, p. 6372-81 10 p.

  Research output: Contribution to journal › Article

  • B-Lymphocyte Subsets 100%
  • Germinal Center 93%
  • Human Herpesvirus 4 78%
  • Marker 69%
  • Blood Cells 64%
  40 Citations (Scopus)