Cellular Immunity to Herpesvirus Infections: Studies with Epstein-Barr Virus (EBV) and Human Cytomegalovirus (CMV)

Research output

Research output per year 2011 2011 2015 2018

• 36 Article
• 1 Comment/debate
• 1 Editorial

Research output per year

Research output per year

Search results

• 2018

  Proteome-wide analysis of CD8+ T cell responses to EBV reveals differences between primary and persistent infection

  Forrest, C., Hislop, A. D., Rickinson, A. B. & Zuo, J., 24 Sept 2018, In: PLoS pathogens. 14, 9, 32 p., e1007110.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human gammaherpesvirus 4 100%
  • Proteome 77%
  • Human Herpesvirus 4 74%
  • proteome 72%
  • T-lymphocytes 68%
  6 Citations (Scopus)

  160 Downloads (Pure)
• 2017

  Cytomegalovirus-specific T cells restricted by HLA-Cw*0702 increase markedly with age and dominate the CD8+ T-Cell repertoire in older people

  Hosie, L., Pachnio, A., Zuo, J., Pearce, H., Riddell, S. & Moss, P., 11 Dec 2017, In: Frontiers in immunology. 8, 1776.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytomegalovirus 100%
  • HLA-C Antigens 63%
  • T-Lymphocytes 62%
  • Peptides 35%
  • HLA-B Antigens 28%
  20 Citations (Scopus)

  180 Downloads (Pure)

• The Transcription Factor Hobit Identifies Human Cytotoxic CD4(+) T Cells

  Oja, A. E., Vieira Braga, F. A., Remmerswaal, E. B. M., Kragten, N. A. M., Hertoghs, K. M. L., Zuo, J., Moss, P. A., van Lier, R. A. W., van Gisbergen, K. P. J. M. & Hombrink, P., 24 Mar 2017, In: Frontiers in immunology. 8, 325.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transcription Factors 100%
  • T-Lymphocytes 82%
  • Cytomegalovirus Infections 24%
  • perforin-granzyme B 8%
  • Phenotype 6%
  21 Citations (Scopus)

  199 Downloads (Pure)
• 2016

  Cytomegalovirus infection does not impact on survival or time to first treatment in patients with Chronic Lymphocytic Leukaemia

  Parry, H., Damery, S., Hudson, C., Maurer, M., Cerhan, J., Pachnio, A., Begum, J., Slager, S., Fegan, C., Man, S., Pepper, C., Shanafelt, T., Pratt, G. & Moss, P., 15 Jul 2016, In: American Journal of Haematology. 91, 8, p. 776–781

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytomegalovirus Infections 100%
  • B-Cell Chronic Lymphocytic Leukemia 96%
  • Cytomegalovirus 54%
  • Survival 50%
  • Therapeutics 14%
  10 Citations (Scopus)

  129 Downloads (Pure)

• Cytomegalovirus infection is associated with an increase in systolic blood pressure in older individuals

  Firth, C., Harrison, R., Ritchie, S., Wardlaw, J., Ferro, C. J., Starr, J. M., Deary, I. J. & Moss, P., 12 Apr 2016, In: QJM: An International Journal of Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytomegalovirus Infections 100%
  • Cytomegalovirus 90%
  • Blood Pressure 57%
  • Infections 24%
  • Sitting Position 13%
  25 Citations (Scopus)

  154 Downloads (Pure)

• Cytomegalovirus infection leads to development of high frequencies of cytotoxic virus-specific CD4+ T Cells targeted to vascular endothelium

  Pachnio, A., Ciaurriz, M., Begum, J., Lal, N., Zuo, J., Beggs, A. & Moss, P., 8 Sept 2016, In: PLoS pathogens. 12, 9, 25 p., e1005832.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytomegalovirus infections 100%
  • Vascular Endothelium 67%
  • Cytomegalovirus Infections 66%
  • endothelium 63%
  • Cytomegalovirus 59%
  68 Citations (Scopus)

  148 Downloads (Pure)

• Early T Cell Recognition of B Cells following Epstein-Barr Virus Infection: Identifying Potential Targets for Prophylactic Vaccination

  Brooks, J., Long, H., Tierney, R., Shannon-Lowe, C., Leese, A., Fitzpatrick, M., Taylor, G. & Rickinson, A., 20 Apr 2016, In: PLoS pathogens. 12, 4, p. 1 25 p., e1005549.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human gammaherpesvirus 4 100%
  • Epstein-Barr Virus Infections 89%
  • B-lymphocytes 73%
  • T-lymphocytes 68%
  • vaccination 67%
  19 Citations (Scopus)

  263 Downloads (Pure)

• Sociodemographic factors associated with IgG and IgM seroprevalence for human cytomegalovirus infection in adult populations of Pakistan: a seroprevalence survey

  Ibrahim, S., Siddiqui, A. A., Siddiqui, A. R., Ahmed, W., Moss, P. A. H. & Lalani, E-N. M. A., 22 Oct 2016, In: BMC Public Health. 16, 1112.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sociodemographic factors 100%
  • Pakistan 88%
  • Seroepidemiologic Studies 87%
  • Cytomegalovirus Infections 86%
  • Immunoglobulin M 69%
  4 Citations (Scopus)

  128 Downloads (Pure)

• Valaciclovir to prevent Cytomegalovirus mediated adverse modulation of the immune system in ANCA-associated vasculitis (CANVAS): study protocol for a randomised controlled trial

  Chanouzas, D., Dyall, L., Nightingale, P., Ferro, C., Moss, P., Morgan, M. D. & Harper, L., 22 Jul 2016, In: Trials. 17, 1, p. 338 338.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Valacyclovir 100%
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 96%
  • Cytomegalovirus 66%
  • Immune System 52%
  • Randomized Controlled Trials 44%
  9 Citations (Scopus)

  189 Downloads (Pure)
• 2015

  Acyclovir therapy reduces the CD4+ T cell response against the immunodominant pp65 protein from cytomegalovirus in immune competent individuals

  Pachnio, A., Begum, J., Fox, A. & Moss, P., 29 Apr 2015, In: PLoS ONE. 10, 4, e0125287.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cytomegalovirus matrix protein 65kDa 100%
  • Acyclovir 77%
  • Cytomegalovirus 76%
  • T-lymphocytes 50%
  • immune response 45%
  9 Citations (Scopus)

  195 Downloads (Pure)

• Anticytomegalovirus antibody titres are not associated with caregiving burden in younger caregivers

  Vitlic, A., Phillips, A. C., Gallagher, S., Oliver, C., Lord, J. M. & Moss, P., Feb 2015, In: British Journal of Health Psychology. 20, 1, p. 68-84

  Research output: Contribution to journal › Article › peer-review

  File

  • caregiving 100%
  • caregiver 84%
  • Caregivers 83%
  • Cytomegalovirus 81%
  • Antibodies 54%
  2 Citations (Scopus)

  220 Downloads (Pure)

• Characterization of CMV-specific CD4+ T-cell reconstitution following stem cell transplantation through the use of HLA Class II-peptide tetramers identifies patients at high risk of recurrent CMV reactivation

  Raeiszadeh, M., Pachnio, A., Begum, J., Craddock, C., Moss, P. & Chen, F. E., Aug 2015, In: Haematologica. 100, 8, p. e318-22

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• CMV-associated CD4(+) CD28(null) cells in NKG2D-dependent glomerular endothelial injury and kidney allograft dysfunction

  Shabir, S., Smith, H., Kaul, B., Pachnio, A., Jham, S., Kuravi, S., Ball, S., Chand, S., Moss, P., Harper, L. & Borrows, R., 25 Nov 2015, (E-pub ahead of print) In: American Journal of Transplantation.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Null Lymphocytes 100%
  • Allografts 68%
  • Kidney 42%
  • Wounds and Injuries 38%
  • Transplantation 23%
  21 Citations (Scopus)

  130 Downloads (Pure)

• Impact of Cytomegalovirus on Long-Term Mortality and Cancer Risk After Organ Transplantation

  Desai, R., Collett, D., Watson, C. J. E., Johnson, P. J., Moss, P. & Neuberger, J., 20 Feb 2015, In: Transplantation.

  Research output: Contribution to journal › Article › peer-review

  • Organ Transplantation 100%
  • Cytomegalovirus 92%
  • Mortality 46%
  • Cytomegalovirus Infections 40%
  • Neoplasms 29%
  30 Citations (Scopus)

• Induction of lytic cycle sensitizes Epstein-Barr virus infected B cells to NK cell killing that is counteracted by virus-mediated NK cell evasion mechanisms in late lytic cycle

  Williams, L. R., Quinn, L. L., Rowe, M. & Zuo, J., 4 Nov 2015, In: Journal of virology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human gammaherpesvirus 4 100%
  • natural killer cells 93%
  • Human Herpesvirus 4 74%
  • B-lymphocytes 73%
  • Natural Killer Cells 69%
  15 Citations (Scopus)

  167 Downloads (Pure)

• The cellular localization of human cytomegalovirus glycoprotein expression greatly influences the frequency and functional phenotype of specific CD4+ T cell responses

  Pachnio, A., Zuo, J., Ryan, G. B., Begum, J. & Moss, P. A. H., 15 Oct 2015, In: Journal of Immunology. 195, 8, p. 3803-3815

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytomegalovirus 100%
  • Glycoproteins 85%
  • T-Lymphocytes 62%
  • Phenotype 60%
  • Epitopes 7%
  8 Citations (Scopus)

  137 Downloads (Pure)

• The missing link in EBV immune evasion: the BDLF3 gene induces ubiquitination and downregulation of MHC class I and MHC class II

  Quinn, L. L., Williams, L. R., White, C., Forrest, C., Zuo, J. & Rowe, M., 14 Oct 2015, (E-pub ahead of print) In: Journal of virology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • immune evasion 100%
  • Human gammaherpesvirus 4 90%
  • Immune Evasion 85%
  • ubiquitination 84%
  • Ubiquitination 73%
  28 Citations (Scopus)

  141 Downloads (Pure)
• 2014

  A mutation in X-linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein-Barr virus-specific T cells

  Lopez-Granados, E., Stacey, M., Kienzler, A-K., Sierro, S., Willberg, C. B., Fox, C. P., Rigaud, S., Long, H., Hislop, A. D., Rickinson, A. B., Patel, S., Latour, S., Klenerman, P. & Chapel, H., Dec 2014, In: Clinical & Experimental Immunology. 178, 3, p. 470-82 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Economic Inflation 100%
  • Human Herpesvirus 4 88%
  • Memory 64%
  • T-Lymphocytes 54%
  • Apoptosis 54%
  11 Citations (Scopus)

• Cellular immune controls over Epstein-Barr virus infection: new lessons from the clinic and the laboratory

  Rickinson, A. B., Long, H. M., Palendira, U., Münz, C. & Hislop, A. D., Apr 2014, In: Trends in Immunology. 35, 4, p. 159-69 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Epstein-Barr Virus Infections 100%
  • Primary Immunodeficiency Diseases 56%
  • Infectious Mononucleosis 54%
  • Lymphoproliferative Disorders 48%
  • Herpesviridae 47%
  72 Citations (Scopus)

• Cooperation between Epstein-Barr virus immune evasion proteins spreads protection from CD8+ T cell recognition across all three phases of the lytic cycle

  Quinn, L., Zuo, J., Abbott, R., Shannon-Lowe, C., Tierney, R., Hislop, A. & Rowe, M., 21 Aug 2014, In: PLoS pathogens. 10, 8, e1004322.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • immune evasion 100%
  • Human gammaherpesvirus 4 90%
  • Immune Evasion 85%
  • Human Herpesvirus 4 67%
  • epitopes 64%
  28 Citations (Scopus)

  258 Downloads (Pure)
• 2013

  Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and -independent mechanisms : implications for oncogenesis

  Zuo, J., Hislop, A. D., Leung, C. S., Sabbah, S. & Rowe, M., 15 May 2013, In: Journal of virology. 87, 10, p. 5340-5350

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human gammaherpesvirus 8 100%
  • MHC class II transactivator protein 93%
  • antigen presentation 85%
  • interferon regulatory factor-3 79%
  • Human Herpesvirus 8 73%
  15 Citations (Scopus)

  175 Downloads (Pure)

• MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response

  Long, H. M., Chagoury, O. L., Leese, A. M., Ryan, G. B., James, E., Morton, L. T., Abbott, R. J. M., Sabbah, S., Kwok, W. & Rickinson, A. B., 6 May 2013, In: The Journal of Experimental Medicine. 210, 5, p. 933-49 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear Antigens 100%
  • Epstein-Barr Virus Infections 93%
  • Kinetics 56%
  • T-Lymphocytes 47%
  • Infectious Mononucleosis 43%
  61 Citations (Scopus)
• 2012

  Herpesviruses placating the unwilling host : manipulation of the MHC class II antigen presentation pathway

  Zuo, J. & Rowe, M., 22 Aug 2012, In: Viruses. 4, 8, p. 1335-53 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Herpesviridae Infections 100%
  • Herpesviridae 90%
  • Histocompatibility Antigens Class II 85%
  • Antigen Presentation 84%
  • HLA-DR Antigens 56%
  18 Citations (Scopus)

  186 Downloads (Pure)
• 2011

  ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele

  Skowronska, A., Austen, B., Powell, J., Weston, V., Oscier, DG., Dyer, MJS., Matutes, E., Pratt, G., Fegan, C., Moss, P., Taylor, A. & Stankovic, T., 20 Sept 2011, In: Haematologica. 97, 1, p. 142-146 5 p.

  Research output: Contribution to journal › Article

  Open Access

  • B-Cell Chronic Lymphocytic Leukemia 100%
  • Disease Progression 75%
  • Alleles 68%
  • Chromosome Deletion 60%
  • Mutation 52%
  30 Citations (Scopus)

• CD4+CD28- T-cell expansion in Wegener's granulomatosis is driven by latent CMV and is associated with an increased risk of infection and mortality.

  Morgan, M., Pachnio, A., Begum, J., Roberts, D., Rasmussen, N., Neil, D., Bajema, I., Savage, C., Moss, P. & Harper, L., 24 Mar 2011, In: Arthritis & Rheumatism. 63, 7, p. 2127-2137 11 p.

  Research output: Contribution to journal › Article

  • Granulomatosis with Polyangiitis 100%
  • Cytomegalovirus 79%
  • T-Lymphocytes 49%
  • Mortality 40%
  • Infections 38%
  42 Citations (Scopus)

• Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+ forkhead box P3+ T cells

  Piper, K., Karanth, M., McLarnon, A., Kalk, E., Khan, N., Murray, J., Pratt, G. & Moss, P., 1 Nov 2011, In: Clinical & Experimental Immunology. 166, 2, p. 154-63 10 p.

  Research output: Contribution to journal › Article

  • B-Cell Chronic Lymphocytic Leukemia 100%
  • T-Lymphocytes 58%
  • Phenotype 56%
  • Regulatory T-Lymphocytes 31%
  • fludarabine 20%
  34 Citations (Scopus)

• Cytomegalovirus sero positivity dramatically alters the maternal CD8+ T cell repertoire and leads to the accumulation of highly differentiated memory cells during human pregnancy.

  Lissauer, D., Choudhary, M., Pachnio, A., Goodyear, O., Moss, P. & Kilby, M., 5 Oct 2011, In: Human Reproduction. 26, 12, p. 3355-3365 11 p.

  Research output: Contribution to journal › Article

  • Cytomegalovirus 100%
  • Mothers 63%
  • T-Lymphocytes 62%
  • Pregnancy 60%
  • Immunoglobulin G 32%
  19 Citations (Scopus)

• Cytotoxic CD4(+) T Cell Responses to EBV Contrast with CD8 Responses in Breadth of Lytic Cycle Antigen Choice and in Lytic Cycle Recognition

  Long, H., Leese, A., Chagoury, OL., Connerty, SR., Quarcoopome, J., Quinn, L., Shannon-Lowe, C. & Rickinson, A., 1 Jul 2011, In: Journal of Immunology. 187, 1, p. 92-101 10 p.

  Research output: Contribution to journal › Article

  • Human Herpesvirus 4 100%
  • Epitopes 64%
  • Antigens 63%
  • T-Lymphocytes 62%
  • Clone Cells 40%
  49 Citations (Scopus)

• Dominant responses with conservation of T-cell receptor usage in the CD8+ T-cell recognition of a cancer testis antigen peptide presented through HLA-Cw7 in patients with multiple myeloma.

  Goodyear, O., Pearce, H., Pratt, G. & Moss, P., 23 Jul 2011, In: Cancer Immunology Immunotherapy. 60, p. 1751-1761

  Research output: Contribution to journal › Article › peer-review

  • HLA-C*70 antigen 100%
  • Testicular Neoplasms 59%
  • T-Cell Antigen Receptor 53%
  • Multiple Myeloma 51%
  • Peptides 33%
  6 Citations (Scopus)

• Epstein-Barr virus BamHI W repeat number limits EBNA2/EBNA-LP co-expression in newly-infected B-cells and the efficiency of B-cell transformation: a rationale for the multiple W repeats in wild-type virus strains.

  Tierney, R., Kao, KY., Nagra, J. & Rickinson, A., 28 Sept 2011, In: Journal of virology.

  Research output: Contribution to journal › Article

  • Human gammaherpesvirus 4 100%
  • Human Herpesvirus 4 74%
  • B-lymphocytes 73%
  • B-Lymphocytes 57%
  • Viruses 49%
  35 Citations (Scopus)

• Epstein-Barr Virus Evades CD4 T Cell Responses in Lytic Cycle through BZLF1-mediated Downregulation of CD74 and the Cooperation of vBcl-2.

  Zuo, J., Thomas, W., Haigh, T., Fitzsimmons, L., Long, H., Hislop, A., Taylor, G. & Rowe, M., 1 Dec 2011, In: PLoS pathogens. 7, 12, p. e1002455

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • immune evasion 100%
  • Human gammaherpesvirus 4 90%
  • Immune Evasion 85%
  • Human Herpesvirus 4 67%
  • T-lymphocytes 61%
  44 Citations (Scopus)

  194 Downloads (Pure)

• Epstein-Barr virus latent gene sequences as geographical markers of viral origin: unique EBNA3 gene signatures identify Japanese viruses as distinct members of the Asian virus family.

  Sawada, A., Croom-Carter, D., Kondo, O., Yasui, M., Koyama-Sato, M., Inoue, M., Kawa, K., Rickinson, A. & Tierney, R., 1 May 2011, In: Journal of General Virology. 92, Pt 5, p. 1032-43 12 p.

  Research output: Contribution to journal › Article

  • Human Herpesvirus 4 100%
  • Viruses 67%
  • Biomarkers 65%
  • Genes 40%
  • Natural Killer Cells 35%
  14 Citations (Scopus)

• Immune defence against EBV and EBV-associated disease.

  Long, H., Taylor, G. & Rickinson, A., 1 Apr 2011, In: Current Opinion in Immunology. 23, 2, p. 258-64 7 p.

  Research output: Contribution to journal › Article

  • Human Herpesvirus 4 100%
  • Virus Diseases 74%
  • Infectious Mononucleosis 26%
  • T-Lymphocytes 24%
  • Asymptomatic Infections 24%
  73 Citations (Scopus)

• KIR and HLA-C Interactions Promote Differential Dendritic Cell Maturation and Is a Major Determinant of Graft Failure following Kidney Transplantation

  Hanvesakul, R., Kubal, C., Moore, J., Neil, D., Cook, M., Ball, S., Briggs, D., Moss, P. & Cockwell, P., 1 Aug 2011, In: PLoS ONE. 6, 8, p. e23631

  Research output: Contribution to journal › Article

  Open Access

  • kidney transplant 100%
  • HLA-C Antigens 96%
  • KIR Receptors 96%
  • dendritic cells 88%
  • natural killer cells 74%
  15 Citations (Scopus)

• Renal function in patients transplanted for NASH cirrhosis: Time to reconsider immunosuppression regimens?

  Houlihan, D., Armstrong, M., Davidov, Y., Hodson, J., Nightingale, P., Rowe, I., Paris, S., Gunson, B., Bramhall, S., Mutimer, D., Neuberger, J. & Newsome, P., 14 Jul 2011, In: Liver Transplantation.

  Research output: Contribution to journal › Article

  • Fatty Liver 100%
  • Immunosuppression 84%
  • Fibrosis 69%
  • Liver Transplantation 66%
  • Kidney 50%
  56 Citations (Scopus)

• The role of tetraspanin CD63 in antigen presentation via MHC class II

  Petersen, SH., Odintsova, E., Haigh, T., Rickinson, A., Taylor, G. & Berditchevski, F., 1 Sept 2011, In: European Journal of Immunology. 41, 9, p. 2556-2561 6 p.

  Research output: Contribution to journal › Article

  • Tetraspanin 30 100%
  • Tetraspanins 77%
  • Antigen Presentation 57%
  • T-Lymphocytes 32%
  • Exosomes 26%
  48 Citations (Scopus)