Cellular Immunity to Herpesvirus Infection: Studies with Epstein-Barr Virus and Human Cytomegalovirus

Research output

Research output per year 2005 2009 2010 2010

• 23 Article
• 1 Editorial

Research output per year

Research output per year

Search results

• 2010

  A novel latent membrane 2 transcript expressed in Epstein-Barr virus-positive NK and T cell lymphoproliferative disease encodes a target for cellular immunotherapy.

  Fox, C., Haigh, T., Taylor, G., Long, H., Lee, S., Shannon-Lowe, C., O'Connor, S., Bollard, CM., Iqbal, J., Chan, WC., Rickinson, A., Bell, A. & Rowe, M., 29 Jul 2010, In: Blood. 116, 19, p. 3695-3704 10 p.

  Research output: Contribution to journal › Article

  • Human Herpesvirus 4 100%
  • Natural Killer Cells 93%
  • Immunotherapy 88%
  • Membrane Proteins 83%
  • T-Lymphocytes 62%
  52 Citations (Scopus)

• CD8(+) T-cell immunity against cancer-testis antigens develops following allogeneic stem cell transplantation and reveals a potential mechanism for the graft-versus-leukemia effect.

  McLarnon, A., Piper, K., Goodyear, O., Arrazi, JM., Mahendra, P., Cook, M., Clark, F., Pratt, G., Craddock, C. & Moss, P., 1 Sept 2010, In: Haematologica. 95, 9, p. 1572-8 7 p.

  Research output: Contribution to journal › Article

  Open Access

  • Testicular Neoplasms 100%
  • Allogeneic Cells 94%
  • Stem Cell Transplantation 91%
  • Leukemia 71%
  • Immunity 71%
  15 Citations (Scopus)

• Chronic Graft Versus Host Disease Is Associated With an Immune Response to Autologous Human Leukocyte Antigen-Derived Peptides

  Smith, H., Hanvesakul, R., Morgan, M., Bentall, A., Briggs, D., Clark, F., Pratt, G., Moss, P., Larche, M. & Ball, S., 1 Sept 2010, In: Transplantation. 90, 5, p. 555-563 9 p.

  Research output: Contribution to journal › Article

  • Graft vs Host Disease 100%
  • HLA Antigens 97%
  • Peptides 60%
  • Enzyme-Linked Immunospot Assay 53%
  • Interferon-gamma 48%
  3 Citations (Scopus)

• Impaired Epstein-Barr virus-specific CD8+ T cell function in X-linked lymphoproliferative disease is restricted to SLAM family positive B cell targets.

  Hislop, A., Palendira, U., Leese, A., Arkwright, PD., Rohrlich, PS., Tangye, SG., Gaspar, HB., Lankester, AC., Moretta, A. & Rickinson, A., 19 Jul 2010, In: Blood. 116, 17, p. 3249-3257 9 p.

  Research output: Contribution to journal › Article

  • Signaling Lymphocytic Activation Molecule Family 100%
  • Lymphoproliferative Disorders 66%
  • Human Herpesvirus 4 56%
  • B-Lymphocytes 43%
  • T-Lymphocytes 35%
  82 Citations (Scopus)

• Induction of a CD8(+) T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia

  Goodyear, O., Agathanggelou, A., Novitzky Basso, I., Siddique, S., McSkeane, T., Ryan, G., Vyas, P., Cavenagh, J., Stankovic, T., Moss, P. & Craddock, C., 1 Sept 2010, In: Blood. 116, 11, p. 1908-1918 11 p.

  Research output: Contribution to journal › Article

  • Sodium Valproate 100%
  • Azacitidine 77%
  • Valproate 76%
  • Testicular Neoplasms 66%
  • Valproic Acid 63%
  240 Citations (Scopus)

• Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise

  Turner, J., Aldred, S., Witard, O., Drayson, M., Moss, P. & Bosch, J., Nov 2010, In: Brain, Behaviour, and Immunity. 24, 8, p. 1362-1370 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytomegalovirus Infections 100%
  • Cytomegalovirus 90%
  • T-Lymphocytes 56%
  • Memory 55%
  • T-Lymphocyte Subsets 16%
  58 Citations (Scopus)

• Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display

  Leung, CS., Haigh, T., Mackay, LK., Rickinson, A. & Taylor, G., 1 Feb 2010, In: National Academy of Sciences. Proceedings. 107, 5, p. 2165-2170 6 p.

  Research output: Contribution to journal › Article

  • Macroautophagy 100%
  • Epitopes 61%
  • Antigens 45%
  • Epstein-Barr Virus Nuclear Antigens 17%
  • T-Lymphocyte Epitopes 14%
  83 Citations (Scopus)

• The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukaemia and determines the total CD4+ T cell repertoire.

  Pourgheysari, B., Bruton, R., Parry, H., Billingham, L., Fegan, C., Murray, JA. & Moss, P., 18 Jun 2010, In: Blood. 116, 16, p. 2968-2974 7 p.

  Research output: Contribution to journal › Article

  • B-Cell Chronic Lymphocytic Leukemia 100%
  • Cytomegalovirus 93%
  • T-Lymphocytes 58%
  • Reduction 42%
  • Viruses 17%
  40 Citations (Scopus)

• The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo.

  Weston, V., Oldreive, C., Skowronska, A., Oscier, DG., Pratt, G., Dyer, MJ., Smith, G., Powell, J., Rudzki, Z., Kearns, P., Moss, P., Taylor, A. & Stankovic, T., 25 Nov 2010, In: Blood. 116, 22, p. 4578-87 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Olaparib 100%
  • olaparib 83%
  • Poly(ADPribose) 74%
  • Poly(ADP-ribose) Polymerase Inhibitors 71%
  • Ataxia Telangiectasia 68%
  217 Citations (Scopus)
• 2009

  Cyclical expression of EBV latent membrane protein 1 in EBV-transformed B cells underpins heterogeneity of epitope presentation and CD8+ T cell recognition.

  Brooks, J., Lee, S., Leese, A., Thomas, W., Rowe, M. & Rickinson, A., 15 Feb 2009, In: Journal of Immunology. 182, 4, p. 1919-28 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Herpesvirus 4 100%
  • Epitopes 86%
  • Membrane Proteins 83%
  • B-Lymphocytes 77%
  • T-Lymphocytes 62%
  22 Citations (Scopus)

• Specific Targeting of the EBV Lytic Phase Protein BNLF2a to the Transporter Associated with Antigen Processing Results in Impairment of HLA Class I-Restricted Antigen Presentation

  Horst, D., van Leeuwen, D., Croft, N., Garstka, MA., Hislop, A., Kremmer, E., Rickinson, A., Wiertz, EJHJ. & Ressing, ME., 1 Feb 2009, In: Journal of Immunology. 182, 4, p. 2313-2324 12 p.

  Research output: Contribution to journal › Article

  • Histocompatibility Antigens Class I 100%
  • Antigen Presentation 92%
  • HLA Antigens 86%
  • Human Herpesvirus 4 83%
  • Endoplasmic Reticulum 48%
  73 Citations (Scopus)

• Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle.

  Croft, N., Shannon-Lowe, C., Bell, A., Horst, D., Kremmer, E., Ressing, ME., Wiertz, EJ., Middeldorp, JM., Rowe, M., Rickinson, A. & Hislop, A., 1 Jun 2009, In: PLoS pathogens. 5, 6, p. e1000490

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human gammaherpesvirus 4 100%
  • Human Herpesvirus 4 74%
  • Viruses 49%
  • viruses 48%
  • T-lymphocytes 34%
  62 Citations (Scopus)

  148 Downloads (Pure)

• T cell detection of a B-cell tropic virus infection: newly-synthesised versus mature viral proteins as antigen sources for CD4 and CD8 epitope display.

  Mackay, L., Long, H., Brooks, J., Taylor, G., Leung, CS., Chen, A., Wang, F. & Rickinson, A., 1 Dec 2009, In: PLoS pathogens. 5, 12, p. e1000699

  Research output: Contribution to journal › Article

  Open Access

  • CD8 Antigens 100%
  • CD4 Antigens 91%
  • viral proteins 83%
  • Viral Proteins 77%
  • B-lymphocytes 71%
  25 Citations (Scopus)

• The effects of acute malaria on Epstein-Barr virus (EBV) load and EBV-specific T cell immunity in Gambian children.

  Njie, R., Bell, A., Jia, H., Croom-Carter, D., Chaganti, S., Hislop, A., Whittle, H. & Rickinson, A., 1 Jan 2009, In: The Journal of Infectious Diseases. 199, 1, p. 31-8 8 p.

  Research output: Contribution to journal › Article

  • Acute malaria 100%
  • Human Herpesvirus 4 65%
  • Immunity 53%
  • T-Lymphocytes 40%
  • Child 28%
  63 Citations (Scopus)

• Upregulation of Interleukin 7 Receptor Alpha and Programmed Death 1 Marks an Epitope-Specific CD8(+) T-Cell Response That Disappears following Primary Epstein-Barr Virus Infection

  Sauce, D., Larsen, M., Abbott, R., Hislop, A., Leese, A., Khan, N., Papagno, L., Freeman, GJ. & Rickinson, A., 1 Sept 2009, In: Journal of virology. 83, 18, p. 9068-9078 11 p.

  Research output: Contribution to journal › Article

  • glycyl-leucyl-cysteinyl-threonyl-leucyl-valyl-alanyl-methionyl-leucine 100%
  • interleukin-7 72%
  • Interleukin-7 Receptors 68%
  • Human gammaherpesvirus 4 59%
  • Infectious Mononucleosis 58%
  15 Citations (Scopus)
• 2008

  Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow

  Palendira, U., Chinn, R., Raza, W., Piper, K., Pratt, G., Machado, L., Bell, A., Khan, N., Hislop, A., Steyn, R., Rickinson, A., Buckley, C. & Moss, P., 15 Oct 2008, In: Blood. 112, 8, p. 3293-302 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Partition 97%
  • Antigen 82%
  • Bone Marrow 71%
  • Viruses 65%
  62 Citations (Scopus)

  6 Downloads (Pure)
• 2007

  A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates

  Hislop, A., Ressing, ME., van Leeuwen, D., Pudney, V., Horst, D., Koppers-Lalic, D., Croft, N., Neefjes, JJ., Rickinson, A. & Wiertz, EJHJ., 6 Aug 2007, In: The Journal of Experimental Medicine. 204, 8, p. 1863-73 11 p.

  Research output: Contribution to journal › Article

  • Immune Evasion 100%
  • Human Herpesvirus 4 78%
  • Primates 73%
  • Herpesviridae 73%
  • HLA Antigens 65%
  127 Citations (Scopus)

• IL7Ra versus CCR7 and CD45 as markers of virus specific CD8+ T cell differentiation: Contrasting pictures in blood and tonsillar lymphoid tissue

  Sauce, D., Larsen, M., Leese, A., Millar, D., Khan, N., Hislop, A. & Rickinson, A., 15 Jan 2007, In: The Journal of Infectious Diseases. 195, p. 268-278 11 p.

  Research output: Contribution to journal › Article

  • Lymphoid Tissue 100%
  • Human Herpesvirus 4 92%
  • Cell Differentiation 75%
  • Viruses 61%
  • Cytomegalovirus 61%
  20 Citations (Scopus)
• 2006

  EBV-associated mononucleosis leads to long-term global deficit in T cell responsiveness to IL-15

  Sauce, D., Larsen, M., Curnow, S., Leese, A., Moss, P., Hislop, A., Salmon, M. & Rickinson, A., 1 Jul 2006, In: Blood. 108, p. 11-18 8 p.

  Research output: Contribution to journal › Article

  • Infectious Mononucleosis 100%
  • Interleukin-15 96%
  • Human Herpesvirus 4 75%
  • T-Lymphocytes 46%
  • Epstein-Barr Virus Infections 36%
  47 Citations (Scopus)
• 2005

  CD8⁺ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells

  Pudney, V., Leese, A., Rickinson, A. & Hislop, A., 7 Feb 2005, In: The Journal of Experimental Medicine. 201, 3, p. 349-360 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Antigen Presentation 100%
  • Human Herpesvirus 4 91%
  • Epitopes 62%
  • Antigens 58%
  • T-Lymphocytes 34%
  96 Citations (Scopus)

• Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genes

  Khan, N., Bruton, R., Taylor, G., Cobbold, M., Jones, TR., Rickinson, A. & Moss, P., 1 Mar 2005, In: Journal of virology. 79, p. 2869-2879 11 p.

  Research output: Contribution to journal › Article

  • cytotoxic T-lymphocytes 100%
  • Cytomegalovirus 99%
  • Vaccinia virus 93%
  • Viral Genes 83%
  • Cytotoxic T-Lymphocytes 76%
  41 Citations (Scopus)

• Tonsillar homing of Epstein-Barr virus - specific CD8+ T cells and the virus-host balance

  Hislop, A., Kuo, M., Drake-Lee, A., Akbar, AN., Bergler, W., Hammerschmitt, N., Khan, N., Palendira, U., Leese, A., Timms, JM., Bell, A., Buckley, C. & Rickinson, A., 1 Sept 2005, In: Journal of Clinical Investigation. 115, 9, p. 2546-2555 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Palatine Tonsil 100%
  • Human Herpesvirus 4 85%
  • Infectious Mononucleosis 85%
  • Viruses 57%
  • Epitopes 55%
  85 Citations (Scopus)

  142 Downloads (Pure)

• Virus-specific cytotoxic T lymphocytes differentially express cell-surface leukocyte immunoglobulin-like receptor-1, an inhibitory receptor for class I major histocompatibility complex molecule

  Antrobus, TD., Khan, N., Hislop, A., Montamat-Sicotte, D., Garner, L., Rickinson, A., Moss, P. & Willcox, B., 1 Jun 2005, In: The Journal of Infectious Diseases. 191, 11, p. 1842-1853 12 p.

  Research output: Contribution to journal › Article

  • B-Cell Antigen Receptors 100%
  • Histocompatibility Antigens Class I 93%
  • Cytotoxic T-Lymphocytes 84%
  • Major Histocompatibility Complex 80%
  • Immunoglobulins 69%
  24 Citations (Scopus)