Biochemical characterisation of pivotal enzymes involved in mycobacterial mycolic acid biosynthesis

Besra, Del (Principal Investigator)
Bhatt, Apoorva (Co-Investigator)
Futterer, Klaus (Co-Investigator)

Biosciences

9 Article

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2013
Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis
Gómez-Velasco, A., Bach, H., Rana, A. K., Cox, L. R., Bhatt, A., Besra, G. S. & Av-Gay, Y., Apr 2013, In: Microbiology (Reading, England). 159, 4, p. 726-736
Research output: Contribution to journal › Article › peer-review

Open Access
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21 Citations (Scopus)

217 Downloads (Pure)
Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis
Sambandan, D., Dao, D. N., Weinrick, B. C., Vilchèze, C., Gurcha, S. S., Ojha, A., Kremer, L., Besra, G. S., Hatfull, G. F. & Jacobs, W. R., 2013, In: mBio. 4, 3, p. e00222-13
Research output: Contribution to journal › Article › peer-review

Open Access
63 Citations (Scopus)
2012
MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria
Varela, C., Rittmann, D., Singh, A., Krumbach, K., Bhatt, K., Eggeling, L., Besra, G. & Bhatt, A., 1 Apr 2012, In: Chemistry & Biology. 19, 4, p. 498-506 9 p.
Research output: Contribution to journal › Article
131 Citations (Scopus)
2011
A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection
Montamat-Sicotte, DJ., Millington, KA., Willcox, C., Hingley-Wilson, S., Hackforth, S., Innes, J., Kon, OM., Lammas, D., Minnikin, D., Besra, G., Willcox, B. & Lalvani, A., 1 Jun 2011, In: Journal of Clinical Investigation. 121, 6, p. 2493-2503 11 p.
Research output: Contribution to journal › Article
72 Citations (Scopus)
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.
Usha, V., Gurcha, S., Lovering, A., Lloyd, A., Papaemmanouil, A., Reynolds, RC. & Besra, G., 1 Jan 2011, In: Microbiology. 157, Pt 1, p. 290-9 10 p.
Research output: Contribution to journal › Article
31 Citations (Scopus)
Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations
Gokulan, K., Aggarwal, A., Shipman, L., Besra, G. & Sacchettini, JC., 1 Jul 2011, In: Acta Crystallographica Section D Biological Crystallography. 67, p. 657-669 13 p.
Research output: Contribution to journal › Article
9 Citations (Scopus)
Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component
Stoop, EJM., Schipper, T., Huber, SKR., Nezhinsky, AE., Verbeek, FJ., Gurcha, S., Besra, G., Vandenbroucke-Grauls, CMJE., Bitter, W. & van der Sar, AM., 1 Jul 2011, In: Disease Models and Mechanisms. 4, 4, p. 526-536 11 p.
Research output: Contribution to journal › Article
84 Citations (Scopus)
2010
Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis
Taylor, R., Brown, AK., Singh, A., Bhatt, A. & Besra, G., 1 Jul 2010, In: Microbiology. 156, p. 1975-1982 8 p.
Research output: Contribution to journal › Article
16 Citations (Scopus)
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars
Westwood, I. M., Bhakta, S., Russell, A. J., Fullam, E., Anderton, M. C., Kawamura, A., Mulvaney, A. W., Vickers, R. J., Bhowruth, V., Besra, G. S., Lalvani, A., Davies, S. G. & Sim, E., 2010, In: Protein & cell. 1, 1, p. 82-95 14 p.
Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus)