A new mass spectrometer for structural proteomics and protein imaging

Thomas, Chris (Co-Investigator)
Grant, Melissa (Co-Investigator)
Lovering, Andrew (Co-Investigator)
Alderwick, Luke (Co-Investigator)
Tomlinson, Michael (Co-Investigator)
Winn, Peter (Co-Investigator)
Knowles, Tim (Co-Investigator)
Cooper, Helen (Principal Investigator)
Styles, Iain (Co-Investigator)
Gibbs, Daniel (Co-Investigator)
Huber, Damon (Co-Investigator)
Bhatt, Apoorva (Co-Investigator)
Leney, Aneika (Co-Investigator)

13 Article

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2024
Laser capture microdissection and native mass spectrometry for spatially-resolved analysis of intact protein assemblies in tissue †
Hughes, JW., Sisley, E. K., Hale, O. J. & Cooper, H. J., 7 Mar 2024, (E-pub ahead of print) In: Chemical Science.
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2023
High-Throughput Deconvolution of Native Protein Mass Spectrometry Imaging Data Sets for Mass Domain Analysis
Hale, O., Cooper, H. J. & Marty, M. T., 19 Sept 2023, In: Analytical Chemistry. 95, 37, p. 14009-14015 7 p.
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Tissue Washing Improves Native Ambient Mass Spectrometry Detection of Membrane Proteins Directly from Tissue
Sisley, E. K., Hale, O. J., Hughes, J. W. & Cooper, H. J., 26 Jul 2023, In: Journal of the American Chemical Society. 145, 29, p. 15658-15662 5 p.
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2022
FAIMS enhances the detection of PTM crosstalk sites
Adoni, K. R., Cunningham, D. L., Heath, J. K. & Leney, A. C., 1 Apr 2022, In: Journal of Proteome Research. 21, 4, p. 930-939 10 p.
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Mass Spectrometry Detection and Imaging of a Non-Covalent Protein-Drug Complex in Tissue from Orally Dosed Rats
Illes-Toth, E., Hale, O. J., Hughes, J. W., Strittmatter, N., Rose, J., Clayton, B., Sargeant, R., Jones, S., Dannhorn, A., Goodwin, R. J. A. & Cooper, H. J., 13 Jul 2022, (E-pub ahead of print) In: Angewandte Chemie (International Edition) . 61, 36, e202202075.
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Native Ambient Mass Spectrometry Enables Analysis of Intact Endogenous Protein Assemblies up to 145 kDa Directly from Tissue
Hale, O. J., Hughes, J. W., Sisley, E. K. & Cooper, H. J., 12 Apr 2022, In: Analytical Chemistry. 94, 14, p. 5608-5614 7 p.
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Native Ambient Mass Spectrometry Imaging of Ligand-Bound and Metal-Bound Proteins in Rat Brain
Sisley, E. K., Hale, O. J., Styles, I. B. & Cooper, H. J., 9 Feb 2022, In: Journal of the American Chemical Society. 144, 5, p. 2120-2128 9 p.
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Native Ambient Mass Spectrometry of an Intact Membrane Protein Assembly and Soluble Protein Assemblies Directly from Lens Tissue
Hale, O. J. & Cooper, H. J., 1 Aug 2022, In: Angewandte Chemie (International Edition) . 61, 31, e202201458.
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Probing heavy metal binding to phycobiliproteins
Bellamy-Carter, J., Sound, J. K. & Leney, A. C., 14 Feb 2022, (E-pub ahead of print) In: The FEBS journal. 289, 15, p. 4646-4656
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The increasing role of structural proteomics in cyanobacteria
Sound, J., Bellamy-Carter, J. & Leney, A., 12 Dec 2022, (E-pub ahead of print) In: Essays in Biochemistry. EBC20220095.
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2021
Native mass spectrometry imaging of proteins and protein complexes by nano-DESI
Hale, O. & Cooper, H., 16 Mar 2021, In: Analytical Chemistry. 93, 10, p. 4619–4627 9 p.
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Rapid cyanobacteria species identification with high sensitivity using native mass spectrometry
Sound, J. K., Peters, A., Bellamy-Carter, J., Rad-Menéndez, C., MacKechnie, K., Green, D. H. & Leney, A. C., 26 Oct 2021, In: Analytical Chemistry. 93, 42, p. 14293-14299 7 p.
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2020
High-field asymmetric waveform ion mobility spectrometry and native mass spectrometry: analysis of intact protein assemblies and protein complexes
Hale, O. J., Illes-Toth, E., Mize, T. H. & Cooper, H. J., 19 May 2020, In: Analytical Chemistry. 92, 10, p. 6811-6816 6 p.
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A new mass spectrometer for structural proteomics and protein imaging

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