Yu-Chiang Lai

Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents

Lai, Y. C., Zarrinpashneh, E. & Jensen, J., 1 May 2010, In: Journal of Applied Physiology. 108, 5, p. 1106-1115 10 p.

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34 Citations (Scopus)

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner

Seabright, A., Fine, N., Barlow, J., Lord, S., Musa, I., Gray, A., Bryant, J., Banzhaf, M., Lavery, G., Hardie, D. G., Hodson, D., Philp, A. & Lai, Y-C., May 2020, In: FASEB Journal. 34, 5, p. 6284-6301 18 p.

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11 Citations (Scopus)

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AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Johanns, M., Lai, Y. C., Hsu, M. F., Jacobs, R., Vertommen, D., Van Sande, J., Dumont, J. E., Woods, A., Carling, D., Hue, L., Viollet, B., Foretz, M. & Rider, M. H., 8 Mar 2016, In: Nature Communications. 7, 10856.

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63 Citations (Scopus)

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A novel PKB/Akt inhibitor, MK-2206,effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle

Lai, Y. C., Liu, Y., Jacobs, R. & Rider, M. H., 1 Oct 2012, In: Biochemical Journal. 447, 1, p. 137-147 11 p.

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38 Citations (Scopus)

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: Comparison with effects of contraction and other AMPK activators

Lai, Y. C., Kviklyte, S., Vertommen, D., Lantier, L., Foretz, M., Viollet, B., Hallén, S. & Rider, M. H., 15 Jun 2014, In: Biochemical Journal. 460, 3, p. 363-375 13 p.

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44 Citations (Scopus)

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

Bultot, L., Lai, Y. C., Jensen, T. E., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, E. A. & Sakamoto, K., 1 Oct 2016, In: American Journal of Physiology - Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.

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33 Citations (Scopus)

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Characteristics of glycemic control in elite power and endurance athletes

Chou, S. W., Lai, Y. C., Lai, C. H., Hsu, T. H., Cho, Y. M., Ho, H. Y., Chen, S. M., Ho, C. F. & Kuo, C. H., May 2005, In: Preventive Medicine. 40, 5, p. 564-569 6 p.

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9 Citations (Scopus)

Consumption of carbohydrate solutions enhances energy intake without increased body weight and impaired insulin action in rat skeletal muscles

Ruzzin, J., Lai, Y. C. & Jensen, J., Apr 2005, In: Diabetes and Metabolism. 31, 2, p. 178-188 11 p.

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7 Citations (Scopus)

Effect of insulin and contraction on glycogen synthase phosphorylation and kinetic properties in epitrochlearis muscles from lean and obese Zucker rats

Lin, F. C., Lai, Y. C., Bolling, A., Stuenaes, J. T., Cumming, K. T., Ingvaldsen, A., Ivy, J. L. & Jensen, J., 15 May 2012, In: American Journal of Physiology - Cell Physiology. 302, 10, p. C1539-C1547 9 p.

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5 Citations (Scopus)

Effects of adrenaline on whole-body glucose metabolism and insulin-mediated regulation of glycogen synthase and PKB phosphorylation in human skeletal muscle

Jensen, J., Lai, Y. C., Ruge, T., Svensson, M. K. & Eriksson, J. W., 1 Feb 2011, In: Metabolism: Clinical and Experimental. 60, 2, p. 215-226 12 p.

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17 Citations (Scopus)

Effects of hiking at altitude on body composition and insulin sensitivity in recovering drug addicts

Lee, W. C., Lai, Y. C., Chen, J. J., Hunt, D. D., Hou, C. W., Lin, F. C., Chen, C. Y., Lin, C. H., Liao, Y. H. & Kuo, C. H., 1 Oct 2004, In: Preventive Medicine. 39, 4, p. 681-688 8 p.

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10 Citations (Scopus)

Effects of pharmacological AMP deaminase inhibition and ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle

Plaideau, C., Lai, Y. C., Kviklyte, S., Zanou, N., Löfgren, L., Andersén, H., Vertommen, D., Gailly, P., Hue, L., Bohlooly-Y, M., Hallén, S. & Rider, M. H., 20 Nov 2014, In: Chemistry and Biology. 21, 11, p. 1497-1510 14 p.

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23 Citations (Scopus)

Exercise mediates ubiquitin signalling in human skeletal muscle

Lord, S. O. & Lai, Y-C., Jun 2022, In: FASEB BioAdvances. 4, 6, p. 402-407 6 p.

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Global deletion of 11β-HSD1 prevents muscle wasting associated with glucocorticoid therapy in polyarthritis

Webster, J. M., Sagmeister, M. S., Fenton, C. G., Seabright, A. P., Lai, Y. C., Jones, S. W., Filer, A., Cooper, M. S., Lavery, G. G., Raza, K., Langen, R. & Hardy, R. S., 22 Jul 2021, In: International Journal of Molecular Sciences. 22, 15, 14 p., 7828.

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Glycogen content and contraction regulate glycogen synthase phosphorylation and affinity for UDP-glucose in rat skeletal muscles

Lai, Y. C., Stuenæs, J. T., Kuo, C. H. & Jensen, J., 1 Dec 2007, In: American Journal of Physiology - Endocrinology and Metabolism. 293, 6, p. E1622-E1629 8 p.

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34 Citations (Scopus)

Glycogen content regulates insulin- but not contraction-mediated glycogen synthase activation in the rat slow-twitch soleus muscles

Lai, Y. C., Lin, F. C. & Jensen, J., 1 Oct 2009, In: Acta Physiologica. 197, 2, p. 139-150 12 p.

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10 Citations (Scopus)

GSK-3β regulation in skeletal muscles by adrenaline and insulin: Evidence that PKA and PKB regulate different pools of GSK-3

Jensen, J., Lai, Y. C., Brennesvik, E. O. & Shepherd, P. R., 1 Jan 2007, In: Cellular Signalling. 19, 1, p. 204-210 7 p.

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33 Citations (Scopus)

Insulin action and signalling in fat and muscle from dexamethasone-treated rats

Burén, J., Lai, Y. C., Lundgren, M., Eriksson, J. W. & Jensen, J., 1 Jun 2008, In: Archives of Biochemistry and Biophysics. 474, 1, p. 91-101 11 p.

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91 Citations (Scopus)

Insulin-stimulated glycogen synthesis and glycogen synthase activation after electrical stimulation of epitrochlearis muscles with different initial glycogen contents

Lai, Y. C., Stuenæs, J. T., Kuo, C. H. & Jensen, J., 1 Jul 2010, In: Archives of Physiology and Biochemistry. 116, 3, p. 116-127 12 p.

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7 Citations (Scopus)

Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

Osgerby, L., Lai, Y-C., Thornton, P. J., Amalfitano, J., Le Duff, C. S., Jabeen, I., Kadri, H., Miccoli, A., Tucker, J. H. R., Muqit, M. M. K. & Mehellou, Y., 27 Apr 2017, In: Journal of Medicinal Chemistry. 60, 8, p. 3518-3524 7 p.

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37 Citations (Scopus)

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Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle

Liu, Y., Lai, Y. C., Vertommen, D. & Rider, M. H., 1 Sept 2013, In: Cellular Signalling. 25, 9, p. 1877-1886 10 p.

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35 Citations (Scopus)

Nicotinamide riboside augments the aged human skeletal muscle NAD⁺ metabolome and induces transcriptomic and anti-inflammatory signatures

Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., Cartwright, D. M., Oakey, L., Burley, C. V., Jenkinson, N., Wilson, M., Lucas, S. J. E., Akerman, I., Seabright, A., Lai, Y., Tennant, D. A., Nightingale, P., Wallis, G. A., Manolopoulos, K. N., Brenner, C., & 2 othersPhilp, A. & Lavery, G. G., 13 Aug 2019, In: Cell Reports. 28, 7, p. 1717-1728.e6 19 p.

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73 Citations (Scopus)

284 Downloads (Pure)

PDX1^LOW MAFA^LOW β-cells contribute to islet function and insulin release

Nasteska, D., Fine, N., Ashford, F., Cuozzo, F., Viloria, K., Smith, G., Dahir, A., Dawson, P. W. J., Lai, Y-C., Bastidas-Ponce, A., Bakhti, M., Rutter, G., Fiancette, R., Nano, R., Piemonti, L., Lickert, H., Zhou, Q., Akerman, I. & Hodson, D., 29 Jan 2021, In: Nature Communications. 12, 1, 19 p., 674.

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5 Citations (Scopus)

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Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

Liu, Y., Lai, Y. C., Hill, E. V., Tyteca, D., Carpentier, S., Ingvaldsen, A., Vertommen, D., Lantier, L., Foretz, M., Dequiedt, F., Courtoy, P. J., Erneux, C., Viollet, B., Shepherd, P. R., Tavare, J. M., Jensen, J. & Rider, M. H., 15 Oct 2013, In: Biochemical Journal. 455, 2, p. 195-206 12 p.

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36 Citations (Scopus)

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Lai, Y. C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J. C., Campbell, D. G., Itzen, A., Trost, M. & Muqit, M. M. K., 12 Nov 2015, In: EMBO Journal. 34, 22, p. 2840-2861 22 p.

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106 Citations (Scopus)

Postexercise muscle glycogen synthesis with glucose, galactose, and combined galactose-glucose ingestion

Podlogar, T., Shad, B. J., Seabright, A. P., Odell, O. J., Lord, S. O., Civil, R., Salgueiro, R. B., Shepherd, E. L., Lalor, P. F., Elhassan, Y. S., Lai, Y-C., Rowlands, D. S. & Wallis, G. A., Dec 2023, In: American Journal of Physiology - Endocrinology and Metabolism. 325, 6, p. E672-E681

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Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation

Pao, K. C., Stanley, M., Han, C., Lai, Y. C., Murphy, P., Balk, K., Wood, N. T., Corti, O., Corvol, J. C., Muqit, M. M. K. & Virdee, S., 7 Mar 2016, In: Nature Chemical Biology. 12, 5, p. 324-331 8 p.

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59 Citations (Scopus)

Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance

Jensen, J. & Lai, Y. C., 1 Feb 2009, In: Archives of Physiology and Biochemistry. 115, 1, p. 13-21 9 p.

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59 Citations (Scopus)

The effect of ex vivo human serum from liver disease patients on cellular protein synthesis and growth

Allen, S. L., Seabright, A. P., Quinlan, J. I., Dhaliwal, A., Williams, F. R., Fine, N. H. F., Hodson, D. J., Armstrong, M. J., Elsharkaway, A. M., Greig, C. A., Lai, Y-C., Lord, J. M., Lavery, G. G. & Breen, L., 24 Mar 2022, In: Cells. 11, 7, 19 p., 1098.

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Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis

Fenton, C., Webster, J., Martin, C., Fareed, S., Wehmeyer, C., Mackie, H., Jones, R., Seabright, A., Lewis, J., Lai, Y-C., Goodyear, C. S., Jones, S., Cooper, M. S., Lavery, G., Langen, R., Raza, K. & Hardy, R., 1 Aug 2019, In: Arthritis Research & Therapy. 21, 1, 182.

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7 Citations (Scopus)

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The role of dehydroepiandrosterone levels on physiologic acclimatization to chronic mountaineering activity

Lee, W. C., Lai, Y. C., Chen, S. M., Wu, M. C., Hou, C. W., Laio, Y. H., Lin, C. H. & Kuo, C. H., 1 Sept 2006, In: High Altitude Medicine and Biology. 7, 3, p. 228-236 9 p.

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22 Citations (Scopus)

The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise

Jensen, J., Lai, Y. C., Rustad, P. I. & Kolnes, A. J., 2011, In: Frontiers in Physiology. 2, 11 p., Article 112.

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152 Citations (Scopus)

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Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 muscle cells

Nishimura, Y., Chunthorng-Orn, J., Lord, S., Musa, I., Dawson, P., Holm, L. & Lai, Y-C., 7 Jul 2022, In: AJP: Cell Physiology. 323, 1, p. C215-C225

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Uncovering the mechanisms of MuRF1-induced ubiquitylation and revealing similarities with MuRF2 and MuRF3

Lord, S. O., Dawson, P. W. J., Chunthorng-Orn, J., Ng, J., Baehr, L. M., Hughes, D. C., Sridhar, P., Knowles, T., Bodine, S. C. & Lai, Y-C., Mar 2024, In: Biochemistry and Biophysics Reports. 37, 101636.

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β-Adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA

Stuenæs, J. T., Lai, Y. C., Bolling, A., Ingvaldsen, A., Rommundstad, C., Sudar, E., Lin, F. C. & Jensen, J., 1 May 2010, In: British Journal of Pharmacology. 160, 1, p. 116-129 14 p.

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20 Citations (Scopus)

Yu-Chiang Lai

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