Tracey Haigh

2024

Bioengineered small extracellular vesicles deliver multiple SARS‐CoV‐2 antigenic fragments and drive a broad immunological response

Jackson, H. K., Long, H. M., Yam‐Puc, J. C., Palmulli, R., Haigh, T. A., Gerber, P. P., Lee, J. S., Matheson, N. J., Young, L., Trowsdale, J., Lo, M., Taylor, G. S., Thaventhiran, J. E. & Edgar, J. R., 9 Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, e12412.

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2023

Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4⁺ T cell immunity

Chen, Y., Mason, G., Scourfield, D. O., Greenshields-Watson, A., Haigh, T., Sewell, A., Long, H., Gallimore, A., Rizkallah, P., MacLachlan, B. & Godkin, A., 29 Aug 2023, In: Cell Reports. 42, 8, 22 p., 112827.

Research output: Contribution to journal › Article › peer-review

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2022

Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4⁺ T cell recognition

Tye, E., Jinks, E., Haigh, T., Kaul, B., Patel, P., Parry, H., Newby, M., Crispin, M., Kaur, N., Moss, P., Drennan, S., Taylor, G. & Long, H., 1 Dec 2022, In: Nature Immunology. 23, p. 1726–1734 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2021

Cytotoxic CD4+ T-cells specific for EBV capsid antigen BORF1 are maintained in long-term latently infected healthy donors

Dowell, A. C., Haigh, T. A., Ryan, G. B., Turner, J. E., Long, H. M. & Taylor, G. S., 9 Dec 2021, In: PLoS Pathogens. 17, 12, e1010137.

Research output: Contribution to journal › Article › peer-review

Open Access

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35 Downloads (Pure)

2019

Heterologous prime-boost vaccination protects against EBV antigen-expressing lymphomas

Ruhl, J., Citterio, C., Engelmann, C., Haigh, T., Dzionek, A., Dreyer, J., Khanna, R., Taylor, G., Wilson, J., Leung, C. & Munz, C., 1 May 2019, In: Journal of Clinical Investigation. 129, 5, p. 2071-2087 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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22 Citations (Scopus)

118 Downloads (Pure)

2013

Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205

Leung, C. S., Maurer, M. A., Meixlsperger, S., Lippmann, A., Cheong, C., Zuo, J., Haigh, T. A., Taylor, G. S. & Münz, C., 28 Feb 2013, In: Blood. 121, 9, p. 1584-94 11 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

2011

Epstein-Barr Virus Evades CD4 T Cell Responses in Lytic Cycle through BZLF1-mediated Downregulation of CD74 and the Cooperation of vBcl-2.

Zuo, J., Thomas, W., Haigh, T., Fitzsimmons, L., Long, H., Hislop, A., Taylor, G. & Rowe, M., 1 Dec 2011, In: PLoS pathogens. 7, 12, p. e1002455

Research output: Contribution to journal › Article › peer-review

Open Access

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44 Citations (Scopus)

194 Downloads (Pure)

The role of tetraspanin CD63 in antigen presentation via MHC class II

Petersen, SH., Odintsova, E., Haigh, T., Rickinson, A., Taylor, G. & Berditchevski, F., 1 Sept 2011, In: European Journal of Immunology. 41, 9, p. 2556-2561 6 p.

Research output: Contribution to journal › Article

48 Citations (Scopus)

2010

A novel latent membrane 2 transcript expressed in Epstein-Barr virus-positive NK and T cell lymphoproliferative disease encodes a target for cellular immunotherapy.

Fox, C., Haigh, T., Taylor, G., Long, H., Lee, S., Shannon-Lowe, C., O'Connor, S., Bollard, CM., Iqbal, J., Chan, WC., Rickinson, A., Bell, A. & Rowe, M., 29 Jul 2010, In: Blood. 116, 19, p. 3695-3704 10 p.

Research output: Contribution to journal › Article

52 Citations (Scopus)

Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display

Leung, CS., Haigh, T., Mackay, LK., Rickinson, A. & Taylor, G., 1 Feb 2010, In: National Academy of Sciences. Proceedings. 107, 5, p. 2165-2170 6 p.

Research output: Contribution to journal › Article

83 Citations (Scopus)

2008

EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4(+) cytotoxic T cell recognition of EBV-transformed B cell lines

Haigh, T., Lin, XR., Jia, H., Hui, EP., Chan, ATC., Rickinson, A. & Taylor, G., 1 Jan 2008, In: Journal of Immunology. 180, 3, p. 1643-1654 12 p.

Research output: Contribution to journal › Article

50 Citations (Scopus)

2006

A role for inter-cellular antigen transfer in the recognition of Epstein-Barr virus (EBV)-transformed B cell lines by EBV nuclear antigen-specific CD4+ T cells

Taylor, G., Long, H., Haigh, T., Larsen, M., Brooks, J. & Rickinson, A., 1 Jan 2006, In: Journal of Immunology. 177, p. 3746-3756 11 p.

Research output: Contribution to journal › Article

61 Citations (Scopus)

EBV-specific CD4+ T cell clones exhibit vigorous allogeneic responses

Landais, E., Morice, A., Long, H., Haigh, T., Charreau, B., Bonneville, M., Taylor, G. & Houssaint, E., 1 Aug 2006, In: Journal of Immunology. 177, 3, p. 1427-1433 7 p.

Research output: Contribution to journal › Article

30 Citations (Scopus)

2005

CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell lines

Long, H., Haigh, T., Gudgeon, N., Leen, AM., Tsang, C., Brooks, J., Landais, E., Houssaint, E., Lee, S., Rickinson, A. & Taylor, G., 15 Apr 2005, In: Journal of virology. 79, p. 4896-4907 12 p.

Research output: Contribution to journal › Article › peer-review

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95 Citations (Scopus)

325 Downloads (Pure)

Regression of Epstein-Barr virus-induced B-cell transformation in vitro involves virus-specific CD8+ T cells as the principal effectors and a novel CD4+ T-cell reactivity

Gudgeon, N., Taylor, G., Long, H., Haigh, T. & Rickinson, A., 1 May 2005, In: Journal of virology. 79, p. 5477-5488 12 p.

Research output: Contribution to journal › Article

31 Citations (Scopus)

2004

CD8 T cell recognition of endogenously expressed Epstein-Barr virus nuclear antigen 1

Lee, S., Brooks, J., Al-Jarrah, H., Thomas, W., Haigh, T., Taylor, G., Humme, S., Schepers, A., Hammerschmidt, W., Yates, JL., Rickinson, A. & Blake, NW., 1 Jan 2004, In: The Journal of Experimental Medicine. 199, p. 1409-1420 12 p.

Research output: Contribution to journal › Article

131 Citations (Scopus)

Dual stimulation of Epstein-Barr virus (EBV)-specific CD4+- and CD8+- T-cell responses by a chimeric antigen construct: Potential therapeutic vaccine for EBV-positive nasopharyngeal carcinoma

Taylor, G., Haigh, T., Gudgeon, N., Phelps, RJ., Lee, S., Steven, N. & Rickinson, A., 1 Jan 2004, In: Journal of virology. 78, p. 768-778 11 p.

Research output: Contribution to journal › Article

100 Citations (Scopus)

2003

Epstein-Barr virus nuclear antigen 1 (EBNA1) induced cytotoxicity in epithelial cells is associated with EBNA1 degradation and processing.

Jones, R., Smith, LJ., Dawson, C., Haigh, T., Blake, NW. & Young, L., 1 Sept 2003, In: Virology. 313, 2, p. 663-76 14 p.

Research output: Contribution to journal › Article

15 Citations (Scopus)

Identification of a TAP-independent immunoproteasome-dependent CD8+ T-cell epitope in the Epstein-Barr virus latent membrane protein 2

Lautscham, G., Haigh, T., Mayrhofer, S., Taylor, G., Croom-Carter, D., Leese, A., Gadola, S., Cerundolo, V., Rickinson, A. & Blake, N., 15 Feb 2003, In: Journal of virology. 77, 4, p. 2757-2761 5 p.

Research output: Contribution to journal › Article

43 Citations (Scopus)

2002

Adenovirally transduced dendritic cells induce bispecific cytotoxic T lymphocyte responses against adenovirus and cytomegalovirus pp65 or against adenovirus and Epstein-Barr virus EBNA3C protein: A novel approach for immunotherapy

Hamel, Y., Blake, N., Gabrielsson, SS., Haigh, T., Jooss, K., Martinache, C., Caillat-Zucman, S., Rickinson, A., Hacein-Bey, S. & Fischer, A., 1 May 2002, In: Human Gene Therapy. 13, p. 855-866 12 p.

Research output: Contribution to journal › Article

37 Citations (Scopus)

2001

Processing of a multiple membrane spanning Epstein-Barr virus protein for CD8(+) T cell recognition reveals a proteasome-dependent, transporter associated with antigen processing-independent pathway

Lautscham, G., Mayrhofer, S., Taylor, G., Haigh, T., Leese, A., Rickinson, A. & Blake, N., 8 Oct 2001, In: The Journal of Experimental Medicine. 194, p. 1053-1068 16 p.

Research output: Contribution to journal › Article

63 Citations (Scopus)

Tracey Haigh

Research output

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