Thomas Jackson

2025

A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study

Hurdle bio‐infrastructure team, Schmunk, L. J., Call, T. P., McCartney, D. L., Javaid, H., Hastings, W. J., Jovicevic, V., Kojadinović, D., Tomkinson, N., Zlamalova, E., McGee, K. C., Sullivan, J., Campbell, A., McIntosh, A. M., Óvári, V., Wishart, K., Behrens, C. E., Stone, E., Gavrilov, M. & Thompson, R. & 5 others, Jackson, T., Lord, J. M., Stubbs, T. M., Marioni, R. E. & Martin‐Herranz, D. E., 30 Jan 2025, (E-pub ahead of print) In: Aging Cell. e14444.

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Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS-A multicentre case-control study

COVID-CNS Study Group, Shil, R. S. K., Seed, A., Franklyn, N. E., Sargent, B. F., Wood, G. K., Huang, Y., Dodd, K. C., Lilleker, J. B., Pollak, T. A., Defres, S., Jenkins, T. M., Davies, N. W. S., Cousins, D. A., Zandi, M. S., Jackson, T. A., Benjamin, L. A., Easton, A., Solomon, T. & Bradley, J. R. & 9 others, Chinnery, P. F., Smith, C. J., Nicholson, T. R., Carson, A., Thomas, R. H., Ellul, M. A., Wood, N. W., Breen, G. & Michael, B. D., 27 Jan 2025, In: Scientific Reports. 15, 1, 14 p., 3443.

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2024

A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age

McGee, K. C., Sullivan, J., Hazeldine, J., Schmunk, L. J., Martin-Herranz, D. E., Jackson, T. & Lord, J. M., 26 Mar 2024, (E-pub ahead of print) In: GeroScience. 15 p.

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Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial

Shrestha, A., Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T., Avenell, A., Band, M. M., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Hume, C., Jackson, T. A., Kerr, S. & Kilgour, A. & 17 others, Masud, T., McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Sayer, A. A., Rossios, C., Smith, K. T., Soiza, R. L., Steves, C. J., Struthers, A. D., Tiwari, D., Whitney, J., Witham, M. D., Kemp, P. R. & De Rui, M. (Editor), 2 Aug 2024, In: PLOS One. 19, 8, 14 p., e0307268.

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Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

ISARIC4C Investigators, COVID-CNS Consortium, Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., Boardman, S. A., Clark, J. J., Sharma, P., Subramaniam, K., Wood, G. K., Collie, C., Digby, R., Ren, A., Norton, E., Leibowitz, M., Ebrahimi, S. & Fower, A. & 28 others, Fox, H., Tato, E., Ellul, M. A., Sunderland, G., Held, M., Hetherington, C., Egbe, F. N., Palmos, A., Stirrups, K., Grundmann, A., Chiollaz, A. C., Sanchez, J. C., Stewart, J. P., Griffiths, M., Solomon, T., Breen, G., Coles, A. J., Kingston, N., Bradley, J. R., Chinnery, P. F., Cavanagh, J., Irani, S. R., Vincent, A., Baillie, J. K., Openshaw, P. J., Semple, M. G., Taams, L. S. & Menon, D. K., Dec 2024, In: Nature Communications. 15, 1, 1 p., 2918.

Research output: Contribution to journal › Comment/debate › peer-review

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Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis

Welch, C., Bravo, L., Gkoutos, G., Greig, C., Lewis, D., Lord, J., Majid, Z., Masud, T., McGee, K., Moorey, H., Pinkney, T., Stanley, B. & Jackson, T., 23 Jun 2024, (E-pub ahead of print) In: Aging and Disease.

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Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

PHOSP-COVID Collaborative Group, ISARIC investigators, Jackson, T., Broome, M., McArdle, P., Moss, P., Thickett, D., Upthegrove, R., Wraith, D., Aldera, E. L., Green, C. & McGee, K., Apr 2024, In: Nature Immunology. 25, 4, p. 607-621 15 p.

Research output: Contribution to journal › Letter › peer-review

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Maintaining independence in individuals with dementia at home after a fall: a protocol for the UK pilot cluster randomised controlled trial MAINTAIN

Greene, L., Barber, R., Bingham, A., Connors, J., Conroy, S., Elkhafer, K., Fox, C., Goodwin, V., Gordon, A., Hall, A. J., Harwood, R. H., Hulme, C., Jackson, T., Litherland, R., Morgan-Trimmer, S., Pankiewicz, S., Parry, S. W., Sharma, A., Ukoumunne, O. & Whale, B. & 1 others, Allan, L., 1 Feb 2024, In: BMJ open. 14, 2, 9 p., e083494.

Research output: Contribution to journal › Article › peer-review

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Oculomic stratification of COVID-19 patients’ intensive therapy unit admission status and mortality by retinal morphological findings

Courtie, E., Taylor, M., Danks, D., Acharjee, A., Jackson, T., Logan, A., Veenith, T. & Blanch, R. J., 12 Sept 2024, In: Scientific Reports. 14, 21312.

Research output: Contribution to journal › Article › peer-review

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Perceptions on artificial intelligence-based decision making for coexisting multiple long-term health conditions: A protocol for a qualitative study with patients and healthcare professionals

Gunathilaka, N., Gooden, T., Cooper, J., Flanagan, S., Marshall, T., Haroon, S., D'Elia, A., Crowe, F., Jackson, T., Nirantharakumar, K. & Greenfield, S., 1 Feb 2024, In: BMJ open. 14, 31 p., e077156.

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Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction

COVID-CNS Consortium & Veenith, T., 23 Sept 2024, (E-pub ahead of print) In: Nature Medicine.

Research output: Contribution to journal › Article › peer-review

‘If you’ve lost your personality, there’s no point in changing the valve’—a qualitative study of older adults’ attitudes towards treatment of aortic stenosis with comorbid dementia

Skaar, E., Rostoft, S., Cruz-Jentoft, A., Jackson, T., Bleie, Ø., Packer, E., Øksnes, A. & Schaufel, M. A., 12 Nov 2024, In: BMJ open. 14, 11, 9 p., e086674.

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2023

ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial

Rossios, C., Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T., Avenell, A., Band, M. M., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Hume, C., Jackson, T. A., Kerr, S. & Kilgour, A. & 15 others, Masud, T., McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Sayer, A. A., Smith, K. T., Soiza, R. L., Steves, C. J., Struthers, A. D., Tiwari, D., Whitney, J., Witham, M. D. & Kemp, P. R., 20 Oct 2023, In: PLOS One. 18, 10, 17 p., e0292402.

Research output: Contribution to journal › Article › peer-review

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A clinical frailty scale obtained from MDT discussion performs poorly in assessing frailty in haemodialysis recipients

Anderson, B. M., Qasim, M., Correa, G., Evison, F., Gallier, S., Ferro, C. J., Jackson, T. A. & Sharif, A., 30 Mar 2023, In: BMC Nephrology. 24, 1, 80.

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Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia—Analyses from the LACE randomised controlled trial

Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T., Avenell, A., Band, M. M., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Hume, C., Jackson, T. A., Kerr, S., Kilgour, A. & Masud, T. & 15 others, McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Rossios, C., Sayer, A. A., Smith, K. T., Soiza, R. L., Steves, C. J., Struthers, A. D., Tiwari, D., Whitney, J., Witham, M. D. & Kemp, P. R., 14 Nov 2023, In: PLoS ONE. 18, 11, 18 p., e0294330.

Research output: Contribution to journal › Article › peer-review

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Advancing specificity in delirium: The delirium subtyping initiative

Bowman, E. M. L., Brummel, N. E., Caplan, G. A., Cunningham, C., Evered, L. A., Fiest, K. M., Girard, T. D., Jackson, T. A., LaHue, S. C., Lindroth, H. L., Maclullich, A. M. J., McAuley, D. F., Oh, E. S., Oldham, M. A., Page, V. J., Pandharipande, P. P., Potter, K. M., Sinha, P., Slooter, A. J. C. & Sweeney, A. M. & 5 others, Tieges, Z., Van Dellen, E., Wilcox, M. E., Zetterberg, H. & Cunningham, E. L., 31 Jul 2023, (E-pub ahead of print) In: Alzheimer's & Dementia. 12 p.

Research output: Contribution to journal › Article › peer-review

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A rehabilitation intervention to improve recovery after an episode of delirium in adults over 65 years (RecoverED): study protocol for a multi-centre, single-arm feasibility study

Allan, L., O’connell, A., Raghuraman, S., Bingham, A., Laverick, A., Chandler, K., Connors, J., Jones, B., Um, J., Morgan-Trimmer, S., Harwood, R., Goodwin, V. A., Ukoumunne, O. C., Hawton, A., Anderson, R., Jackson, T., Maclullich, A. M. J., Richardson, S., Davis, D. & Collier, L. & 4 others, Strain, W. D., Litherland, R., Glasby, J. & Clare, L., 15 Sept 2023, In: Pilot and Feasibility Studies. 9, 1, 13 p., 162.

Research output: Contribution to journal › Article › peer-review

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Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort

Krogseth, M., Davis, D. H. J., Jackson, T. A., Zetterberg, H., Watne, L. O., Lindberg, M., Chitalu, P., Tsui, A., Selbæk, G. & Wyller, T. B., Aug 2023, In: The Lancet Healthy Longevity. 4, 8, p. e399-e408 10 p.

Research output: Contribution to journal › Article › peer-review

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1 Citation (Scopus)

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Depression is associated with frailty and lower quality of life in haemodialysis recipients, but not with mortality or hospitalization

Anderson, B. M., Qasim, M., Correa, G., Evison, F., Gallier, S., Ferro, C. J., Jackson, T. A. & Sharif, A., Feb 2023, In: Clinical Kidney Journal. 16, 2, p. 342-354 13 p.

Research output: Contribution to journal › Article › peer-review

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Development of a UK core dataset for geriatric medicine research: a position statement and results from a Delphi consensus process

Geriatric Medicine Core Dataset Extended Working Group, Welch, C., Wilson, D., Sayer, A. A., Witham, M. D. & Jackson, T. A., 23 Mar 2023, In: BMC Geriatrics. 23, 1, 168.

Research output: Contribution to journal › Article › peer-review

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Exploring fraity and sarcopenia in older adults admitted to acute medical unit, looking at prevalence, trajectory, and outcomes: A protocol testing the feasibility and acceptability of the TYSON study

Kamwa, V., Jackson, T., Hassan-Smith, Z. & Sapey, E., 3 Nov 2023, In: PLoS ONE. 18, 11, 12 p., e0293650.

Research output: Contribution to journal › Article › peer-review

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Gender Disparity in Expression of Sarcopenia in Haemodialysis Recipients: Analysis from the FITNESS Cohort

Anderson, B. M., Wilson, D. V., Qasim, M., Correa, G., Evison, F., Gallier, S., Ferro, C. J., Jackson, T. A. & Sharif, A., 17 Jun 2023, In: International journal of nephrology. 2023, 14 p., 5885059 .

Research output: Contribution to journal › Article › peer-review

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Global uncertainty in the diagnosis of neurological complications of SARS-CoV-2 infection by both neurologists and non-neurologists: An international inter-observer variability study

Global NeuroResearch Coalition, Tamborska, A. A., Wood, G. K., Westenberg, E., Garcia-Azorin, D., Webb, G., Schiess, N., Netravathi, M., Baykan, B., Dervaj, R., Helbok, R., Lant, S., Özge, A., Padovani, A., Saylor, D., Schmutzhard, E., Easton, A., Lilleker, J. B., Jackson, T. & Beghi, E. & 10 others, Ellul, M. A., Frontera, J. A., Pollak, T., Nicholson, T. R., Wood, N., Thakur, K. T., Solomon, T., Stark, R. J., Winkler, A. S. & Michael, B. D., 15 Jun 2023, In: Journal of the Neurological Sciences. 449, 7 p., 120646.

Research output: Contribution to journal › Article › peer-review

Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

Geriatric Medicine Research Collaborative, 25 Jan 2023, (E-pub ahead of print) In: European Geriatric Medicine.

Research output: Contribution to journal › Article › peer-review

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Investigating the impact of fluid status on the ultrasound assessment of muscle quantity and quality in the diagnosis of sarcopenia – a multidimensional cross-sectional study

Stanley, B., Greig, C., Jackson, T., Lewis, D., Moorey, H., Majid, Z., Masud, T., Pinkney, T. & Welch, C., 15 Aug 2023, In: BMC Geriatrics. 23, 1, 11 p., 493.

Research output: Contribution to journal › Article › peer-review

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Prevalence and demographic variation of cardiovascular, renal, metabolic, and mental health conditions in 12 million english primary care records

Cooper, J., Nirantharakumar, K., Crowe, F., Azcoaga-Lorenzo, A., McCowan, C., Jackson, T., Acharya, A., Gokhale, K., Gunathilaka, N., Marshall, T. & Haroon, S., 16 Oct 2023, In: BMC Medical Informatics and Decision Making. 23, 1, 16 p., 220.

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Repurposing digoxin for geroprotection in patients with frailty and multimorbidity

Lee, H., Wilson, D., Bunting, K. V., Kotecha, D. & Jackson, T., 1 Apr 2023, In: Ageing Research Reviews. 86, 9 p., 101860.

Research output: Contribution to journal › Review article › peer-review

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Somatic Symptoms of Depression Lose Association with Mortality upon Adjustment for Frailty: Analysis from the Fitness Haemodialysis Cohort

Anderson, B. M., Qasim, M., Correa, G., Evison, F., Gallier, S., Ferro, C. J., Jackson, T. A. & Sharif, A., 21 Jun 2023, In: International journal of nephrology. 2023, 13 p., 4518843.

Research output: Contribution to journal › Article › peer-review

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Trends in delirium coding rates in older hospital inpatients in England and Scotland: full population data comprising 7.7M patients per year show substantial increases between 2012 and 2020

Ibitoye, T., Jackson, T. A., Davis, D. & MacLullich, A. M. J., 29 Jul 2023, In: Delirium Communications.

Research output: Contribution to journal › Article › peer-review

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Ultrasound quadriceps muscle thickness is variably associated with frailty in haemodialysis recipients

Anderson, B. M., Wilson, D. V., Qasim, M., Correa, G., Evison, F., Gallier, S., Ferro, C. J., Jackson, T. A. & Sharif, A., 18 Jan 2023, In: BMC Nephrology. 24, 1, 16.

Research output: Contribution to journal › Article › peer-review

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2022

A Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity

Taylor, J. A., Greenhaff, P. L., Bartlett, D. B., Jackson, T. A., Duggal, N. A. & Lord, J. M., 14 Oct 2022, (E-pub ahead of print) In: Physiological Reviews.

Research output: Contribution to journal › Review article › peer-review

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Consensus clinical guidance for diagnosis and management of adult COVID-19 encephalopathy patients

Global COVID-19 Neuro Research Coalition, 25 Jul 2022, (E-pub ahead of print) In: Journal of Neuropsychiatry and Clinical Neurosciences.

Research output: Contribution to journal › Article › peer-review

Correlations, agreement and utility of frailty instruments in prevalent haemodialysis patients: baseline cohort data from the FITNESS study

Anderson, B. M., Qasim, M., Correa, G., Evison, F., Gallier, S., Ferro, C. J., Jackson, T. A. & Sharif, A., Jan 2022, In: Clinical Kidney Journal. 15, 1, p. 145-152 8 p., sfab137.

Research output: Contribution to journal › Article › peer-review

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Delirium and COVID-19: a narrative review of emerging evidence

White, L. & Jackson, T., 10 Jan 2022, In: Anaesthesia. 77, S1, p. 49-58 10 p.

Research output: Contribution to journal › Review article › peer-review

Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial

LACE study group, 16 Feb 2022, (E-pub ahead of print) In: Journal of cachexia, sarcopenia and muscle. 13, 2, p. 858-871

Research output: Contribution to journal › Article › peer-review

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Effect of regional vs general anesthesia on incidence of postoperative delirium in older patients undergoing hip fracture surgery: the RAGA randomized trial

RAGA Study Investigators, Li, T., Yuan, L., Wu, J., Jiang, C., Daniels, J., Mehta, R. L., Wang, M., Yeung, J., Jackson, T., Melody, T., Jin, S., Yao, Y., Wu, J., Chen, J., Smith, F. G., Lian, Q. & Li, J., 4 Jan 2022, In: JAMA The Journal of the American Medical Association. 327, 1, p. 50-58 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Induced frailty and acute sarcopenia are overlapping consequences of hospitalisation in older adults

Welch, C., Greig, C., Majid, Z., Masud, T., Moorey, H., Pinkney, T. & Jackson, T., 1 Sept 2022, In: Journal of frailty, sarcopenia and falls. 7, 3, p. 103-116 14 p.

Research output: Contribution to journal › Article › peer-review

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Outcomes in adults living with frailty receiving cardiopulmonary resuscitation: A systematic review and meta-analysis

Hamlyn, J., Lowry, C., Jackson, T. A. & Welch, C., Sept 2022, In: Resuscitation Plus. 11, 100266.

Research output: Contribution to journal › Article › peer-review

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Self-reported health change in haemodialysis recipients modulates the effect of frailty upon mortality and hospital admissions: outcomes from a large prospective UK cohort

Anderson, B. M., Qasim, M., Correa, G., Evison, F., Gallier, S., Ferro, C. J., Jackson, T. A. & Sharif, A., 16 Oct 2022, (E-pub ahead of print) In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. gfac287.

Research output: Contribution to journal › Article › peer-review

Trajectories of muscle quantity, quality and function measurements in hospitalized older adults

Welch, C., Greig, C., Lewis, D., Majid, Z., Masud, T., Moorey, H., Pinkney, T., Stanley, B. & Jackson, T., Apr 2022, In: Geriatrics & gerontology international. 22, 4, p. 311-318 8 p.

Research output: Contribution to journal › Article › peer-review

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2021

Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study

Geriatric Medicine Research Collaborative, Covid Collaborative, Jackson, T. & Wilson, D., 5 May 2021, In: Age and Ageing. 50, 3, p. 617-630 14 p.

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Fostering healthy aging: the interdependency of infections, immunity and frailty

Vetrano, D. L., Triolo, F., Maggi, S., Malley, R., Jackson, T. A., Poscia, A., Bernabei, R., Ferrucci, L. & Fratiglioni, L., Aug 2021, In: Ageing Research Reviews. 69, 1 p., 101351.

Research output: Contribution to journal › Review article › peer-review

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