Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Dive into the research topics where Shannon O'Brien is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Endomembrane GPCR signalling: 15 years on, the quest continues
Calebiro, D., Miljus, T. & O'Brien, S., Jan 2025, In: Trends in Biochemical Sciences. 50, 1, p. 46-60 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile56 Downloads (Pure) -
Intracrine FFA4 signaling controls lipolysis at lipid droplets
O'Brien, S. L., Tripp, E., Barki, N., Blondel-Tepaz, E., Smith, G., Boufersaoui, A., Roberts, J., Pike, J. A., Correia, J., Miljus, T., Bouvier, M., Tennant, D. A., Hudson, B. D., Gerhart-Hines, Z., Milligan, G., Schwartz, T. W. & Calebiro, D., 5 Aug 2025, (E-pub ahead of print) In: Nature Chemical Biology. 29 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signaling
Redfern-Nichols , T., O'Brien, S. L., Huang, X., Medel-Lacruz, B., Calebiro, D., Selent, J., Ladds, G. & Marti-Solano, M., 20 May 2025, In: Science signaling. 18, 887, 12 p., eado7543.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Grimes, J., Koszegi, Z., Lanoiselee, Y., Miljus, T., O'Brien, S. L., Stepniewski, T. M., Medel-Lacruz, B., Baidya, M., Makarova, M., Mistry, R., Goulding, J., Drube, J., Hoffmann, C., Owen, D. M., Shukla, A. K., Selent, J., Hill, S. J. & Calebiro, D., 11 May 2023, In: Cell. 186, 10, p. 2238-2255.e20 39 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile167 Downloads (Pure) -
ADRA1A-Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP
Rahbani, J. F., Scholtes, C., Lagarde, D. M., Hussain, M. F., Roesler, A., Dykstra, C. B., Bunk, J., Samborska, B., O'Brien, S. L., Tripp, E., Pacis, A., Angueira, A. R., Johansen, O. S., Cinkornpumin, J., Hossain, I., Lynes, M. D., Zhang, Y., White, A. P., Pastor, W. A. & Chondronikola, M. & 12 others, , 7 Nov 2022, In: Nature Metabolism. 4, 11, p. 1459–1473 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile125 Downloads (Pure)
Datasets
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Research data supporting "Intracrine FFA4 Signaling Controls Lipolysis at Lipid Droplets"
O'Brien, S. (Creator) & Calebiro, D. (Supervisor), University of Birmingham, 23 Jul 2025
DOI: 10.25500/edata.bham.00001316
Dataset