Sarah Aldred

Accepting PhD Students

PhD projects

Sarah Aldred is an expert in the field of oxidative stress and has been researching chronic diseases of ageing associated with oxidative stress for more than ten years. Her particular research interests focus on the pathology and mechanisms of diseases such as Alzheimer’s disease, vascular dementia and cardiovascular disease. Her research aims to determine the effects of exercise and dietary intervention on disease process. Since 2008 Dr Aldred has developed a unique area of research investigating exercise effects on Alzheimer’s disease pathology, which is respected both nationally and internationally. She has recently been funded by the Alzheimer's Society to research oxidative stress in Alzheimer's disease, and was recently the recipient of a SPARC award to look at the effect of exercise on lipoprotein oxidation in older adults.

Dr Aldred has also led studies investigating the effects of extreme exercise on endogenous antioxidants. Dr Aldred welcomes applications from potential doctoral researchers in her areas of interest.

Research activity per year

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

SDG 3 Good Health and Well-being

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1 Similar Profiles

60 Article
7 Review article
6 Abstract
2 Chapter
More
- 1 Paper
- 1 Conference article

An online study of associations between physical activity, cognitive functioning and food choice
Sardjoe, M., Adam, T., Plasqui, G., Aldred, S., Dourish, C. T. & Higgs, S., 1 Sept 2026, In: Appetite. 224, 12 p., 108562.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Downloads (Pure)
Investigating the effects of post-exercise serum treatments on APP processing in iPSC-derived neurons and astrocytes
Elsworthy, R. J., Spencer, F. S. E., Allen, S., Dunleavy, C., Whitham, M., Lucas, S. J. E., Hill, E. J. & Aldred, S., 2 Mar 2026, In: International Journal of Biochemistry and Cell Biology. 192, 12 p., 106920.
Research output: Contribution to journal › Article › peer-review

Open Access
File
16 Downloads (Pure)
Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes
Elsworthy, R. J., Finelli, M. J., Aqattan, S., Dunleavy, C., King, M., Ludlam, A., Tarczyluk, M. A., Allen, S. L., Prosser, S., Chen, R., Jarquin, S. M., Kim, D. H., Brown, J., Parri, H. R., Aldred, S. & Hill, E. J., Jan 2025, In: Journal of Neurochemistry. 169, 1, 20 p., e16267.
Research output: Contribution to journal › Article › peer-review

Open Access
File
58 Downloads (Pure)
Brain derived neurotrophic factor and secreted amyloid precursor protein-α response to moderate and high intensity exercise
Spencer, F. S. E., Elsworthy, R. J., Breen, L., Bishop, J. R. B., Lucas, S. J. E. & Aldred, S., 22 May 2025, In: Physiological reports. 13, 10, 17 p., e70366.
Research output: Contribution to journal › Article › peer-review

Open Access
File
71 Downloads (Pure)
The effect of the APOE4 genotype on physiological and cognitive health in randomised controlled trials with an exercise intervention: a systematic review and meta-analysis
Spencer, F. S. E., Elsworthy, R. J., Breen, L., Bishop, J. R. B., Dunleavy, C. & Aldred, S., 20 Jan 2025, In: Trials. 26, 1, 29 p., 20.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
126 Downloads (Pure)

4 Active
18 Finished

N Hodson Transfer from MMU - Exploring the (dys) regulation Of The MTORC1-Iysosomal Axis In Obesity-related Skeletal Muscle Anabolic Resistance
Hodson, N. (Principal Investigator) & Aldred, S. (Researcher)
THE ACADEMY OF MEDICAL SCIENCES
1/10/25 → 31/08/26
Project: Research
Detection of novel blood-based biomarkers of neuroinflammation and glial cell reactivity using ultrasensitive (SIMOa) technology in a highly characterised Alzheimer's disease cohort.
Elsworthy, R. (Principal Investigator) & Aldred, S. (Co-Investigator)
ALZHEIMERS RESEARCH UK
1/09/25 → 31/08/26
Project: Research
Building an iPSC-based model to investigate the molecular effects of exercise on APP processing
Di Maio, A. (Co-Investigator), Whitham, M. (Co-Investigator), Elsworthy, R. (Principal Investigator) & Aldred, S. (Co-Investigator)
ALZHEIMERS RESEARCH UK
1/04/25 → 31/03/27
Project: Research
Biomarkers for dementia in at-risk populations
Elsworthy, R. (Co-Investigator) & Aldred, S. (Principal Investigator)
ALZHEIMERS RESEARCH UK
20/01/25 → 30/06/26
Project: Research
Investigating a physiological role for Amyloid-beta in the brain
Aldred, S. (Co-Investigator) & Elsworthy, R. (Principal Investigator)
ALZHEIMERS RESEARCH UK
20/01/25 → 30/12/25
Project: Research

Research data supporting "Brain derived neurotrophic factor (BDNF) and secreted amyloid precursor protein-α (sAPPα) response to moderate and high intensity exercise"
Spencer, F. (Creator), Elsworthy, R. (Creator), Aldred, S. (Creator), Breen, L. (Creator), Bishop, J. R. B. (Creator) & Lucas, S. J. E. (Creator), University of Birmingham, 27 Jan 2025
DOI: 10.25500/edata.bham.00001239
Dataset

Could Tai Chi offer the same benefits as more vigorous exercise?
Aldred, S.
10/10/18
1 item of Media coverage
Press/Media: Press / Media

Sarah Aldred

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

An online study of associations between physical activity, cognitive functioning and food choice

Investigating the effects of post-exercise serum treatments on APP processing in iPSC-derived neurons and astrocytes

Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes

Brain derived neurotrophic factor and secreted amyloid precursor protein-α response to moderate and high intensity exercise

The effect of the APOE4 genotype on physiological and cognitive health in randomised controlled trials with an exercise intervention: a systematic review and meta-analysis

N Hodson Transfer from MMU - Exploring the (dys) regulation Of The MTORC1-Iysosomal Axis In Obesity-related Skeletal Muscle Anabolic Resistance

Detection of novel blood-based biomarkers of neuroinflammation and glial cell reactivity using ultrasensitive (SIMOa) technology in a highly characterised Alzheimer's disease cohort.

Building an iPSC-based model to investigate the molecular effects of exercise on APP processing

Biomarkers for dementia in at-risk populations

Investigating a physiological role for Amyloid-beta in the brain

Research data supporting "Brain derived neurotrophic factor (BDNF) and secreted amyloid precursor protein-α (sAPPα) response to moderate and high intensity exercise"

Could Tai Chi offer the same benefits as more vigorous exercise?

Sarah Aldred

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects

Datasets

Press/Media