Samuel Lara Reyna

Dr.

Accepting PhD Students

20182021

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Personal profile

Research interests

Samuel Lara is a researcher based in the College of Life and Environmental Sciences’ Institute of Microbiology and Infection. He is part of Dr Frickel’s laboratory which investigates mechanisms of human innate defence against pathogens, with a particular interest in Toxoplasma gondii and Salmonella typhimurium.

Samuel’s research primarily focuses in innate immune cells and in studying intracellular mechanism involved in macrophage function. He studies IFNg-driven macrophage inflammation, metabolism and control of intracellular pathogens. He is also interested in autoimmune and autoinflammatory disorders.

Biography

Samuel started his medical training at the faculty of Medicine UJED in Mexico, where he developed an interest in immunology. He obtained his BSc in Biology with Highest Honours and International Distinction at the University of Texas at San Antonio, with a concentration in immunology & microbiology. During his studies in Texas, Samuel gain fundamental research insight at Dr LeBaron’s laboratory of molecular biology.

He was awarded a CONACyT scholarship in 2015 and moved to Birmingham, UK, where he obtained his MSc in Immunology and Immunotherapy at the University of Birmingham. He obtained experience in innate immunity with Professor Andy Clark, where he completed his MSc research project investigating glucocorticoid effects in macrophage function at the Institute of inflammation and ageing.

After his studies at the University of Birmingham, he was awarded the CONACyT/Leeds Graduate Fellowship to accomplish his doctoral studies in Medicine, at the University of Leeds. Samuel’s doctoral research focused on understanding the dysregulated molecular mechanisms of macrophages in autoinflammatory disorders. He studied cystic fibrosis and the dysregulated signalling pathways affecting macrophages in this disease, with interest in inflammation, ER stress and cellular metabolism. He obtained his PhD in Medicine in 2020 at the University of Leeds under the supervisor of Dr Sinisa Savic, Professor Daniel Peckham, and Professor Michael McDermott.

Samuel is currently a postdoctoral research fellow working with Dr Eva Frickel at the Institute of Microbiology and Infection (IMI) at the University of Birmingham. His research focuses on understanding IFNg-driven innate immune responses, mainly in macrophages. He studies the function of guanylate binding proteins (GBPs) in macrophages and how these proteins defend immune cells against different pathogens.

Qualifications

  • PhD in Medicine (Immunology), University of Leeds.
  • MSc in Immunology and Immunotherapy, University of Birmingham.
  • BSc in Molecular Biology, The University of Texas at San Antonio.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Keywords

  • QR180 Immunology
  • Innate Immunity
  • Inflammation
  • Macrophages
  • Immunometabolism
  • R Medicine (General)
  • autoinflammatory disorders
  • Cystic fibrosis
  • Immunity

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